An aerial view of a coastal landscape with a dam, farmland, and dense forests.

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Check availability on Santee Family Hotels

Tonight
Sep 14 - Sep 15
Tomorrow
Sep 15 - Sep 16
This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27

Our top choices for Santee family-friendly hotels

A patio area with wicker furniture, a stone fire pit, and outdoor seating.
A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.
A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.
A reception desk with a wooden panel wall and a circular decorative piece above it.

1. Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
Santee
  • A family escape that offers vibrant pool days, premium entertainment, and free breakfast just minutes from Santee State Park.
￥20,599
￥22,865 total
includes taxes & fees
Sep 21 - Sep 22
Fairfield Inn & Suites by Marriott Santee
A hotel entrance with a sign reading "Best Western PLISS."
A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.
A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

2. Best Western Plus Santee Inn

Best Western Plus Santee Inn
Santee
  • Family vacation paradise with an outdoor pool, fitness center, and quiet, pet-friendly atmosphere for your whole family.
￥17,627
￥19,565 total
includes taxes & fees
Sep 21 - Sep 22
Best Western Plus Santee Inn
A swimming pool with a 5 ft depth marker, surrounded by lounge chairs and a building with multiple windows.
A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.
A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.
A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

3. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
Santee
  • Family-friendly escape at Santee with seasonal outdoor pool, free breakfast, and steps from the state park.
￥15,897
￥17,646 total
includes taxes & fees
Oct 4 - Oct 5
Comfort Inn & Suites Santee
A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.
A small, enclosed bathroom with a shower, grab bars, and a towel rack.
A motel with a brick facade, a covered entrance, and a satellite dish.
A kitchen with a countertop, cabinets, a microwave, and a sink.

4. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
Santee
￥9,831
￥10,913 total
includes taxes & fees
Sep 15 - Sep 16
Travelodge by Wyndham Santee
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.
A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.
A bathroom with a sink, mirror, and a shower area.
A building with a red roof, a yellow door, and a brick facade.

5. Econo Lodge Santee

Econo Lodge Santee
Santee
￥9,859
￥10,944 total
includes taxes & fees
Oct 11 - Oct 12
Econo Lodge Santee
A backyard with a wooden deck, grill, and outdoor seating area.
A single-story mobile home with a covered porch and a small deck, surrounded by a well-maintained lawn and tall trees.
A kitchen with white cabinets, a black countertop, a stainless steel stove, and a refrigerator.
A compact living space with a kitchen, dining area, and a small seating area.

6. Country living lake style near Santee

Country living lake style near Santee
Summerton
￥14,593
￥31,714 total
includes taxes & fees
Sep 15 - Sep 16
Country living lake style near Santee
A clean, well-lit dining area with round tables and chairs, a kitchen in the background, and a decorative leaf on the wall.
A two-story building with a sign reading "PachTree Inn".
A hotel room with two beds, a nightstand, a lamp, a chair, and a painting on the wall.
A reception desk with a clock, framed certificates, and a window with a view.

7. Peach Tree Inn

Peach Tree Inn
St. George
￥9,923
￥10,717 total
includes taxes & fees
Oct 1 - Oct 2
Peach Tree Inn
A Red Roof Inn with two red leather armchairs and a small wooden table in front of a stone-patterned wall.
A hotel reception area with a counter, coffee machines, and a refrigerator.
A two-story building with a grey facade, large windows, and a covered entrance area.
A hotel room with a large bed, bedside tables, a desk, and a chair.

8. Red Roof Inn Orangeburg

Red Roof Inn Orangeburg
Orangeburg
￥8,985
￥9,973 total
includes taxes & fees
Sep 21 - Sep 22
Red Roof Inn Orangeburg
A kitchen with wooden cabinets, a built-in dishwasher, a sink, and a ceiling fan.
A covered porch with a wooden floor, a rocking chair, and a bench.
A kitchen with a built-in dishwasher, wooden cabinets, a marble countertop, and a dining area with a red chair and a table.
A covered outdoor seating area with wooden flooring and metal-framed chairs.

9. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
￥11,751
￥24,981 total
includes taxes & fees
Sep 15 - Sep 16
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
A lobby with a reception desk, a sofa, a small round table, and an American flag.
A Holiday Inn Express & Suites building with a clear entrance, a covered waiting area, and a landscaped garden.
A hotel room with a large bed, a desk, a chair, a nightstand, and a wall-mounted lamp.
A modern hotel lobby with a reception desk, seating area, and a coffee bar.

10. Holiday Inn Express & Suites Orangeburg by IHG

Holiday Inn Express & Suites Orangeburg by IHG
Orangeburg
  • Family-friendly retreat with scenic poolside play, planetarium exploration, and delicious breakfast buffet served daily.
￥16,897
￥18,756 total
includes taxes & fees
Sep 27 - Sep 28
Holiday Inn Express & Suites Orangeburg by IHG
View all properties

Choose what matters most at family-friendly hotels in Santee

Breakfast included
Pool
All-inclusive
4 stars
5 stars

Top Santee Hotel Reviews

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

10/10 Excellent
"Room was very clean and large. Staff were very friendly and enjoyed the breakfast."
Rita 1-night trip
Posted 1 hour ago
Holiday Inn Santee by IHG
Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good
"Bathroom was dated and needed work. However, overall the room was clean and bed was comfortable. We would stay again."
Chris 1-night trip
Posted 1 day ago
Baymont by Wyndham Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

10/10 Excellent
"Great service"
Kunjan 1-night trip
Posted 2 days ago
Travelodge by Wyndham Santee
SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

10/10 Excellent
"Will be stopping there agaun"
Sue 1-night trip
Posted 5 days ago
SureStay Hotel by Best Western Manning
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

8/10 Good
"The price rate was great"
Stevenson 3-night trip
Posted 1 month ago
Ramada by Wyndham Santee I-95

Frequently asked questions

What's Santee like for family-friendly vacations?
The welcoming destination of Santee is a great choice if you've been thinking about a vacation with the kids. The excursions, lake views, and golfing are just a few things that make this an attractive vacation spot for families. Arrange a flight into Columbia Metropolitan Airport (CAE), which is located 49 mi (78.8 km) from the city center.
What's the best place to stay for families in Santee?
Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another choice for your stay with the kids.
When's the best time to book a family-friendly vacation in Santee?
The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do with your family in Santee?
While you and the family are vacationing in Santee, you might want to check out some of the attractions here such as Orangeburg County Library Mentor Branch, Lake Marion, and Edisto Memorial Gardens. Make sure you have lots of time for activities like Congaree National Park and Santee National Wildlife Refuge.

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