Default HTG hotel image

Find hotels in Santa Cruz from ￥3,375

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 24 - Oct 25
Tomorrow
Oct 25 - Oct 26
Next weekend
Oct 30 - Nov 1
In two weeks
Nov 6 - Nov 8

Filter by

Property class

Guest rating

Our top choices for Santa Cruz hotels

A hotel room with a balcony overlooking a cityscape, a bed with patterned pillows, and a painting of a flower on the wall.
A modern hotel room with a large bed, a cityscape mural on the wall, a wooden headboard, and a walk-in closet.
A bar area with a green wall, bar stools, and a counter with a bartender.
A casino with multiple slot machines and chairs arranged in rows.

1. Hotel Dorado La 70

Hotel Dorado La 70
Laureles
United States
Gregson
￥11,763
￥11,763 total
Oct 26 - Oct 27
Hotel Dorado La 70
A hotel sign with a sun emblem, a modern glass building, and flags.
A modern hotel lobby with a reception desk, seating area, and a view of the outdoors.
A neatly arranged bedroom with a bed, bedside table, and a desk with a chair.
A rooftop terrace with lounge chairs and a large umbrella, overlooking a cityscape at dusk.

2. La Quinta by Wyndham Medellin

La Quinta by Wyndham Medellin
San Diego
United States
Rene
￥13,201
￥13,201 total
Oct 30 - Oct 31
La Quinta by Wyndham Medellin
A modern bar with a long counter, shelves with decorative items, and a coffee machine.
A modern hotel lobby with a reception desk, seating area, and large windows.
A city view from a high-rise room with a chair and a table.
A restaurant with multiple tables and chairs, large windows offering a view of mountains and cityscape, and indoor plants.

3. Novotel Medellín El Tesoro

Novotel Medellín El Tesoro
El Poblado
United States
Haydee
￥23,119
￥23,119 total
Nov 16 - Nov 17
Novotel Medellín El Tesoro
A balcony with a white table and chairs, a large potted plant, and a mural with the text "Happy Hour".
A modern dining area with high tables and chairs, a large mural on the wall, and a view of the city through large windows.
A modern hotel room with a large bed, a desk, a blue sofa, and a view of the city.
A gym with treadmills, an elliptical, and weight machines, with a city view through large windows.

4. Novelty Suites Hotel - Oviedo Mall

Novelty Suites Hotel - Oviedo Mall
El Poblado
United States
Karl
￥19,014
￥19,014 total
Oct 30 - Oct 31
Novelty Suites Hotel - Oviedo Mall
An outdoor patio area with wicker furniture, a brick floor, and a view of a building with large windows and indoor lighting.
A modern kitchen area with wooden cabinets, a countertop, and a fruit bowl.
A modern hotel entrance with a prominent sign reading "Fairfield by Marriott" and a staircase leading to the lobby.
A modern kitchen with a central island, bar stools, and a hanging plant.

5. Fairfield by Marriott Medellin Sabaneta

Fairfield by Marriott Medellin Sabaneta
Sabaneta
United States
Michael
￥12,706
￥12,706 total
Nov 1 - Nov 2
Fairfield by Marriott Medellin Sabaneta
A modern hotel room with a large bed, bedside table with a lamp, a desk with a chair, and a potted plant.
A building facade with a large 'nnoa' sign, a window with plants, and a metal utility box on the ground.
A spacious dining area with wooden tables and chairs, surrounded by shelves with plants.
A reception area with a wooden slatted wall, a marble reception desk, and a ceiling with exposed beams and lighting.

6. Moa Select

Moa Select
Laureles
United States
Jorge
￥8,716
￥8,716 total
Oct 27 - Oct 28
Moa Select
A modern restaurant with multiple tables and chairs, a counter with staff, and large windows with a view of greenery.
A reception area with a wooden reception desk, a coffee machine, and a TV screen.
A hotel room with two beds, a desk, and a window.
A gym with a neon sign reading 'GYM MODE ON' and exercise equipment.

7. Hotel Santiago de Arma

Hotel Santiago de Arma
Rionegro
United States
Jose
￥16,331
￥16,331 total
Nov 25 - Nov 26
Hotel Santiago de Arma
Living area
A hotel room with a bed, a desk, a chair, a hanging coat rack, and a view of the outside.
A lobby area with a brown leather sofa, two wicker chairs, a round wooden table, and a black sculpture.
A kitchen with a countertop, a kettle, a coffee pot, and a sink.

8. Obra Hotels

Obra Hotels
El Poblado
United States
Bianca
￥10,830
￥10,830 total
Oct 26 - Oct 27
Obra Hotels
A restaurant with outdoor seating, a brick facade, and a sign reading "LUSSAC".
A hallway with wooden paneling, a chair, and a polished marble floor.
A modern hotel room with a large bed, a bedside table with a lamp, a glass-enclosed balcony, and a bathtub.
A gym with various exercise equipment, a treadmill, and a weight bench.

9. Hotel Park 10

Hotel Park 10
El Poblado
United States
David
￥15,449
￥15,449 total
Oct 26 - Oct 27
Hotel Park 10
A restaurant with wooden tables and benches, a bar area, and large windows offering a view of greenery.
A modern hotel room with a large balcony, a dining table, and chairs.
A modern hotel lobby with a reception desk, seating area, and a green wall with artwork.
A multi-level building with a series of balconies and large cylindrical columns.

10. V Grand Hotel, a member of Radisson Individuals

V Grand Hotel, a member of Radisson Individuals
El Poblado
United States
James
￥14,001
￥14,001 total
Nov 16 - Nov 17
V Grand Hotel, a member of Radisson Individuals
A modern building with a glass facade, a stone pathway, and lush tropical plants.
A modern hotel room with two beds, a large window, a plant, and a TV mounted on the wall.
An outdoor patio with modern furniture, including sofas, chairs, and tables, and a glass door leading to an interior space.
A café with round tables and chairs, a large woven basket centerpiece, and a brick wall background.

11. Lettera Hotel

Lettera Hotel
El Poblado
United States
Gustavo
￥15,545
￥15,545 total
Nov 19 - Nov 20
Lettera Hotel
A room with large windows, a patterned carpet, and a table with chairs.
A modern office space with large windows, a conference table, and a view of the cityscape.
A gym with two people using stationary bikes, a treadmill, and a rowing machine.
A conference room with a long table, multiple chairs, and a large window with a view of trees and buildings.

12. Hotel BH El Poblado

Hotel BH El Poblado
El Poblado
United States
Payam
￥13,559
￥13,559 total
Nov 16 - Nov 17
Hotel BH El Poblado
A hotel room with a bed, a glass-enclosed bathtub, a small table with a chair, and a window with a view of buildings.
A gym with exercise equipment, a punching bag, and a view of the city through large windows.
A modern hotel room with a large bed, bedside tables, a round wooden table, and a white chair.
A modern living room with a round wooden coffee table, white chairs, a sofa, and a potted plant.

13. Arame Hotel

Arame Hotel
Envigado
United States
David
￥11,777
￥11,777 total
Nov 25 - Nov 26
Arame Hotel
A swimming pool with lounge chairs and umbrellas, surrounded by greenery and a brick building.
A hotel room with a large bed, wooden panel walls, a flat-screen TV, and a nightstand with a vase of flowers.
A multi-story building with a brick facade, surrounded by lush greenery and other high-rise buildings.
A hotel lobby with a reception desk, a large potted plant, a check-in counter, and a seating area.

14. Hotel Dann Carlton Belfort Medellin

Hotel Dann Carlton Belfort Medellin
El Poblado
United States
jaime
￥13,382
￥13,382 total
Nov 8 - Nov 9
Hotel Dann Carlton Belfort Medellin
A bedroom with a large bed, a chair, and a view through a glass door.
A modern bedroom with a large bed, wooden headboard, bedside tables, and a view of greenery through a window.
A reception desk with a wooden finish, a logo, and a view of greenery outside.
A garden pathway with various plants and a palm tree.

15. Isak Hotel & Golf Airport

Isak Hotel & Golf Airport
Rionegro
United States
Juwan
￥13,904
￥13,904 total
Nov 6 - Nov 7
Isak Hotel & Golf Airport
A hotel room with two beds, a TV, a balcony with a city view, and artwork on the walls.
Private kitchen
A reception area with a brick wall, wooden tables, wicker pendant lights, and a reception desk.
A hotel room with a bed, a small table with chairs, a coffee maker, and a view of the city through the window.

16. Urbit Social Lofts

Urbit Social Lofts
Laureles
United States
Richard
￥6,862
￥6,862 total
Oct 26 - Oct 27
Urbit Social Lofts
A buffet with various food options, including rice dishes and salads, in a well-lit room with a wooden floor.
A rooftop terrace with two hot tubs, lounge chairs, and a champagne bottle.
A modern hotel building with a unique angular design, multiple floors, and large windows.
A gym with exercise equipment, a wooden floor, and a view of buildings through large windows.

17. GHL Hotel Portón Medellín

GHL Hotel Portón Medellín
El Poblado
United States
Anderson
￥19,382
￥19,382 total
Oct 31 - Nov 1
GHL Hotel Portón Medellín
A spacious lobby with a central staircase, large potted plants, and a chandelier.
A restaurant with a panoramic city view, high ceilings, and modern furnishings.
A rooftop pool with lounge chairs and umbrellas, surrounded by greenery and tall buildings.
A grand lobby with a grand piano, a staircase, and a large window overlooking a garden.

18. Dann Carlton Medellin Hotel

Dann Carlton Medellin Hotel
El Poblado
United States
Luis miguel
￥14,984
￥14,984 total
Nov 2 - Nov 3
Dann Carlton Medellin Hotel
A modern hotel room with a large bed, a bedside phone, and a city view through the window.
A spacious lobby with a high ceiling, modern seating arrangements, and large windows allowing natural light.
A modern lounge with large windows, comfortable seating, and decorative lighting.
A spacious lobby with modern seating, large windows, and decorative lighting.

19. City Express Plus by Marriott Medellin Colombia

City Express Plus by Marriott Medellin Colombia
El Poblado
United States
Heidi
￥10,682
￥10,682 total
Nov 1 - Nov 2
City Express Plus by Marriott Medellin Colombia
A night view from a high-rise building with a cityscape in the background.
A rooftop restaurant with tables and chairs arranged for dining, overlooking a cityscape at night.
A modern kitchen with a central island, bar stools, a hanging chair, and a large window with a view.
A modern bedroom with a hanging chair, a bed, and two pendant lights.

20. Indie Universe Creative Hotel

Indie Universe Creative Hotel
Laureles
United States
Stanislav
￥7,296
￥7,296 total
Nov 25 - Nov 26
Indie Universe Creative Hotel
View all properties

Hotels recommended for families in Santa Cruz

A hotel sign with a sun emblem, a modern glass building, and flags.
A modern hotel lobby with a reception desk, seating area, and a view of the outdoors.
A neatly arranged bedroom with a bed, bedside table, and a desk with a chair.
A rooftop terrace with lounge chairs and a large umbrella, overlooking a cityscape at dusk.

La Quinta by Wyndham Medellin

La Quinta by Wyndham Medellin
San Diego
￥13,201
￥13,201 total
Oct 30 - Oct 31
La Quinta by Wyndham Medellin
A hotel room with a balcony overlooking a cityscape, a bed with patterned pillows, and a painting of a flower on the wall.
A modern hotel room with a large bed, a cityscape mural on the wall, a wooden headboard, and a walk-in closet.
A bar area with a green wall, bar stools, and a counter with a bartender.
A casino with multiple slot machines and chairs arranged in rows.

Hotel Dorado La 70

Hotel Dorado La 70
Laureles
￥11,763
￥11,763 total
Oct 26 - Oct 27
Hotel Dorado La 70
An outdoor patio area with wicker furniture, a brick floor, and a view of a building with large windows and indoor lighting.
A modern kitchen area with wooden cabinets, a countertop, and a fruit bowl.
A modern hotel entrance with a prominent sign reading "Fairfield by Marriott" and a staircase leading to the lobby.
A modern kitchen with a central island, bar stools, and a hanging plant.

Fairfield by Marriott Medellin Sabaneta

Fairfield by Marriott Medellin Sabaneta
Sabaneta
￥12,706
￥12,706 total
Nov 1 - Nov 2
Fairfield by Marriott Medellin Sabaneta
A balcony with a white table and chairs, a large potted plant, and a mural with the text "Happy Hour".
A modern dining area with high tables and chairs, a large mural on the wall, and a view of the city through large windows.
A modern hotel room with a large bed, a desk, a blue sofa, and a view of the city.
A gym with treadmills, an elliptical, and weight machines, with a city view through large windows.

Novelty Suites Hotel - Oviedo Mall

Novelty Suites Hotel - Oviedo Mall
El Poblado
￥19,014
￥19,014 total
Oct 30 - Oct 31
Novelty Suites Hotel - Oviedo Mall
A modern hotel room with a large bed, bedside table with a lamp, a desk with a chair, and a potted plant.
A building facade with a large 'nnoa' sign, a window with plants, and a metal utility box on the ground.
A spacious dining area with wooden tables and chairs, surrounded by shelves with plants.
A reception area with a wooden slatted wall, a marble reception desk, and a ceiling with exposed beams and lighting.

Moa Select

Moa Select
Laureles
￥8,716
￥8,716 total
Oct 27 - Oct 28
Moa Select
A modern bar with a long counter, shelves with decorative items, and a coffee machine.
A modern hotel lobby with a reception desk, seating area, and large windows.
A city view from a high-rise room with a chair and a table.
A restaurant with multiple tables and chairs, large windows offering a view of mountains and cityscape, and indoor plants.

Novotel Medellín El Tesoro

Novotel Medellín El Tesoro
El Poblado
￥23,119
￥23,119 total
Nov 16 - Nov 17
Novotel Medellín El Tesoro
A modern lounge area with a blue sofa, pendant lights, a refrigerator stocked with snacks, and a chalkboard wall with food illustrations.
A modern interior with a blue sofa, a hanging chair, a vending machine, and a refrigerator stocked with beverages.
A modern reception area with a black counter, a digital display, and a wall decorated with food and drink illustrations.
A modern lobby with glass walls, a tiled floor, and a potted plant.

ibis budget Medellín Itagüí Metro

ibis budget Medellín Itagüí Metro
Itagüí
￥5,583
￥5,583 total
Oct 30 - Oct 31
ibis budget Medellín Itagüí Metro
A modern hotel room with a large bed, a wooden headboard, a bedside table with a lamp, and a tray with breakfast items.
A modern reception area with a wooden reception desk, large potted plants, and a view of the outdoors through large windows.
A spacious living area with a leather sofa, a coffee table, and a large window with curtains.
A dining table with a plate of food, wine glasses, and a bottle of wine.

Hotel Lagoon

Hotel Lagoon
Rionegro
￥25,373
￥25,373 total
Oct 27 - Oct 28
Hotel Lagoon
Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Hotel Reviews

Urbit Social Lofts

Urbit Social Lofts

10/10 Excellent
"Good place overall. Medellin I will be back."
Dan 3-night trip
Posted less than an hour ago
Urbit Social Lofts
Laureles Selection Suites

Laureles Selection Suites

10/10 Excellent
"It was very nice staying there"
Sheandry 7-night trip
Posted 5 hours ago
Laureles Selection Suites
Diez Hotel Categoria Colombia

Diez Hotel Categoria Colombia

10/10 Excellent
"Excellent service"
Carmen 3-night trip
Posted 5 hours ago
Diez Hotel Categoria Colombia
The Click Clack Hotel Medellin

The Click Clack Hotel Medellin

10/10 Excellent
"Everything is good with this lodging. Great location. Attractive design with cozy atmosphere. Clean excellent kept location. Delicious food (the breakfast is complete) nice elegant bars, rooftop (in the pricey side); and above all top service with hospitality and 24/7 attention. The regular rooms are small, but my wife and I got lucky and got an courtesy upgrade to a 2XL room which is a suite. Will recommend and go back. THANK to all the staff. You guys are great."
JESUS 3-night trip
Posted 7 hours ago
The Click Clack Hotel Medellin
Moa Select

Moa Select

10/10 Excellent
"Me gusto todoooo desde el personal hasta la limpieza,superrr todo!!!!!es mi segunda vez Y vuelvo 🙏❤️"
Geraldo 4-night trip
Posted 8 hours ago
Moa Select
Marquee Hotel

Marquee Hotel

10/10 Excellent
"Très bel hôtel situé au cœur de El Poblado. La chambre était très confortable et le personnel très gentil! Je recommande!"
Gabrielle 3-night trip
Posted 9 hours ago
Marquee Hotel
Novotel Medellín El Tesoro

Novotel Medellín El Tesoro

10/10 Excellent
"Todo muy bien en el hotel durante nuestra estadía"
Laura 1-night trip
Posted 1 day ago
Novotel Medellín El Tesoro
Heiss Hotel By Jalo

Heiss Hotel By Jalo

10/10 Excellent
"Great services"
JOSE 5-night trip
Posted 2 days ago
Heiss Hotel By Jalo

More cheap stays in Santa Cruz

Hotel Casa Malibú

Hotel Casa Malibú

Calle 32F 66 c 57 Medellín Medellin
￥2,877
￥3,375 total
Oct 27 - Oct 28
4.8/10 (3 reviews)
Hotel Casa Malibú
Autenthico Sajonia Hotel Aeropuerto

Autenthico Sajonia Hotel Aeropuerto

Aeropuerto Jose Maria Cordova, Km 20 Rionegro Antioquia
￥5,310
￥5,310 total
Nov 9 - Nov 10
Autenthico Sajonia Hotel Aeropuerto
Hotel Ofix - Laureles

Hotel Ofix - Laureles

79-86 Calle 44 Medellín
￥5,448
￥5,448 total
Oct 26 - Oct 27
Hotel Ofix - Laureles
Nakúa Stay + Work

Nakúa Stay + Work

8A-29 Cra. 34 Medellín Antioquia
￥9,700
￥9,700 total
Nov 2 - Nov 3
Nakúa Stay + Work
Masaya Medellin

Masaya Medellin

43a1 Cl. 8 Medellín Antioquia
￥12,210
￥12,210 total
Oct 26 - Oct 27
Masaya Medellin
Hotel Loma Verde

Hotel Loma Verde

Calle 11 #30A 117 Medellín Antioquia
￥16,193
￥21,427 total
Nov 8 - Nov 9
Hotel Loma Verde

Frequently asked questions

Where is the best place to stay in Santa Cruz?
Located 6.2 mi (10 km) from the heart of Santa Cruz, Calle Flora Hotel by Jalo is a top choice for your stay based on our traveler data. Other good choices for your trip to the area are Heiss Hotel By Jalo and Hashtag 98 Hotel By Jalo. See all available top hotels, or vacation rentals in Santa Cruz.
What's the top vacation rental that Santa Cruz has to offer?
6 Bedrooms House near Tourist Spots with backyard, Bar, Jacuzzi and heated pool: This vacation home rental near Santa Cruz offers an outdoor pool, a patio, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 6 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You can relax into your vacation with a garden and a hot tub. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
For additional details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.
What is staying in Santa Cruz like?
Visitors are sure to enjoy all that Santa Cruz has to offer. In Santa Cruz, there are 4 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What are the top places to visit in Santa Cruz?
Places to visit in the wider area include Medellin Botanical Garden, Arvi Park, and Antioquia Museum. You'll also find Botero Plaza and Atanasio Giradot Stadium in the area. Check out what more to see and do in Expedia's Santa Cruz guide.
How can I get around Santa Cruz?
Head over to Andalucía MetroCable Station for metro transit. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually August and July with an average temp of 66°F, while the coldest months are December and January with an average of 64°F. The rainiest months in Santa Cruz are May, April, October, and November, with each month seeing an average of 16 inches of rainfall.

Explore a world of travel with Expedia