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Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Santa Cruz vacation rentals

A modern living space with a sofa, a small table, and a view through a large window.

1. Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.0 out of 10, Wonderful, (93 reviews)
"Clean, good location, nice staff"
United States
Sau Yeng
The price is ￥7,368
￥10,842 total
Nov 5 - Nov 6
Metropolitan Living by HOUSY
A modern hotel room with a large bed, a desk, a chair, a potted plant, and a view of the mountains.

2. Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (143 reviews)
"Excellent Stay!"
United States
Esdras
The price is ￥8,627
￥8,627 total
Nov 10 - Nov 11
Go Living and Suites by Jalo
A bedroom with a bed, a bedside table with a plant, a sofa, and a wall with a large blue arch.

3. Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
9.0 out of 10, Wonderful, (7 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is ￥3,815
￥3,815 total
Nov 8 - Nov 9
Hotel Moore 45
A neatly made bed with a wooden headboard, a bedside table with a bottle and a glass, and a chair in a bright room with a large window.

4. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (299 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is ￥11,889
￥11,889 total
Nov 8 - Nov 9
Portal del Rodeo ApartaHotel - Arkadia Mall
A woman standing by a balcony with a view of a rural landscape.

5. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.2 out of 10, Very good, (495 reviews)
"Very clean and a good rear view of landscape"
United States
roberto
The price is ￥15,656
￥15,656 total
Dec 5 - Dec 6
Travelers Rio Verde Living Suites
A modern hotel room with a large bed, a wooden headboard, a bedside table with a lamp, and a view of the city through a large window.

6. ONCE SUITES

ONCE SUITES
3.0 star property
Envigado
10.0 out of 10, Exceptional, (3 reviews)
"Very close to everything"
United States
PAOLA
The price is ￥7,297
￥7,297 total
Nov 5 - Nov 6
ONCE SUITES
A person relaxing in a hot tub with a scenic view of mountains and clouds.

7. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (44 reviews)
"Good location with amazing views, a bit difficult finding . But overall great place to visit."
United States
Giovanni
The price is ￥11,412
￥13,769 total
Nov 30 - Dec 1
Skyline Ecoliving
A modern bedroom with a bed, a sofa, a desk, and a large window with a city view.

8. Apartment Go Living & Suites by HOUSY HOST

Apartment Go Living & Suites by HOUSY HOST
3.5 star property
El Poblado
8.4 out of 10, Very good, (465 reviews)
"Great location, secure place, quiet, private parking"
United States
CAMILO
The price is ￥6,906
￥11,643 total
Nov 5 - Nov 6
Apartment Go Living & Suites by HOUSY HOST
A rooftop terrace with two hot tubs, a dining area with chairs and a table, and a view of a cityscape with mountains in the background.

9. Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (117 reviews)
"Great hotel. Loved the views at the hot tub!"
United States
Maria Lucia
The price is ￥7,108
￥7,108 total
Nov 6 - Nov 7
Quadrato Studios
An outdoor café with tables and chairs, surrounded by potted plants and a view of buildings.

10. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (108 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is ￥6,715
￥6,715 total
Nov 5 - Nov 6
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
An indoor swimming pool with clear glass walls, wooden benches, and tiled columns.

11. PORTANOVA SUITES by ADVENTU

PORTANOVA SUITES by ADVENTU
3.0 star property
Rionegro
8.2 out of 10, Very good, (76 reviews)
"I’ll def be staying at this place whenever I visit Medellín again, they’re located like 5mins away from the airport , transportation is easy to get from there , the check in process was smooth sailing and they’re very good at communicating."
United States
Ternika
The price is ￥8,618
￥11,574 total
Nov 5 - Nov 6
PORTANOVA SUITES by ADVENTU
A living room with a sofa, a small table, and a view of a green hill and buildings.

12. Mountain View, Pool & Gym (2506)

Mountain View, Pool & Gym (2506)
2.5 star property
Sabaneta
10.0 out of 10, Exceptional, (2 reviews)
"Great staff, wonderful view with a store right around the corner."
Canada
Adrian
The price is ￥6,923
￥14,249 total
Dec 4 - Dec 5
Mountain View, Pool & Gym (2506)
A restaurant with wooden tables and chairs, large windows, and a view of the street.

13. Hotel Distrito 70 Living

Hotel Distrito 70 Living
3.0 star property
Laureles - Estadio
8.0 out of 10, Very good, (11 reviews)
"Clean room, the breakfast was good but it was in another location"
United States
Ricardo
The price is ￥6,128
￥6,128 total
Nov 24 - Nov 25
Hotel Distrito 70 Living
A modern restaurant with high ceilings, large windows, and a city view. Tables are set with dishes and drinks.

14. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (75 reviews)
"Room was as expected, didn’t reward the fine print of cooling condition for the room , had a fan available in the room which helped. Appreciate the host, and the security of the building and room especially being I was a solo traveler"
United States
jocelyne
The price is ￥7,493
￥7,493 total
Nov 5 - Nov 6
Edificio Helena
A modern building with a prominent 'N' logo, outdoor seating, and lush greenery.

15. Nomadic Boutique Living and Experience Center

Nomadic Boutique Living and Experience Center
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (48 reviews)
"excellent treat and personal very accessible. Isabel was great"
United States
Dave
The price is ￥9,382
￥10,614 total
Nov 23 - Nov 24
Nomadic Boutique Living and Experience Center
A hotel room with a bed, a nightstand, a lamp, a wall with a decorative design, and a small table with chairs.

16. Amaranto Suites

Amaranto Suites
3.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (7 reviews)
"Perfect"
United States
Alexander
The price is ￥4,994
￥4,994 total
Nov 6 - Nov 7
Amaranto Suites
A modern living room with a sofa, coffee table, and TV. A dining area with a wooden table and chairs is visible. The room has large windows with a city view.

17. Hotel Santa Ana

Hotel Santa Ana
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (46 reviews)
"Great location, superb staff and service and great breakfasts and food options."
United States
Juan Vicente
The price is ￥6,816
￥6,816 total
Nov 5 - Nov 6
Hotel Santa Ana
Room

18. Living 10-36 Dieztreintayseis Short & Long Term

Living 10-36 Dieztreintayseis Short & Long Term
3.5 star property
El Poblado
9.0 out of 10, Wonderful, (72 reviews)
"Loved the room I stayed in and the staff was always accommodating. Great Boutique Hotel to stay."
United States
Rob
The price is ￥9,099
￥9,099 total
Nov 12 - Nov 13
Living 10-36 Dieztreintayseis Short & Long Term
A modern apartment with a living area, kitchenette, and large windows offering city views.

19. Kyux by Jalo

Kyux by Jalo
4.0 star property
Laureles
9.0 out of 10, Wonderful, (205 reviews)
"Great place to stay at"
United States
Miguel
The price is ￥9,157
￥9,157 total
Nov 9 - Nov 10
Kyux by Jalo
A rooftop patio with a hot tub, outdoor seating, and potted plants.

20. Apartaestudios Zeni

Apartaestudios Zeni
2.0 star property
Laureles
10.0 out of 10, Exceptional, (1 review)
"It was very comfortable and accesible"
United States
Jose P
The price is ￥6,218
￥6,218 total
Nov 10 - Nov 11
Apartaestudios Zeni
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Laureles Selection Suites

Laureles Selection Suites

10/10 Excellent
"Nice Hotel, the only bad thing is the area where is located is no the best at night."
Luis 6-night trip
Posted 2 hours ago
Laureles Selection Suites

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

6 Bedrooms House near Tourist Spots with backyard, Bar, Jacuzzi and heated pool: Visitors like this Santa Cruz vacation home rental. It offers an outdoor pool, a patio, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 6 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You can relax into your vacation with a garden and a hot tub.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.