A colonial-style building with a bell tower, palm trees, and a paved walkway.

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Nov 6 - Nov 8
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Nov 13 - Nov 15

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Our top choices for Santa Cruz hotels

A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.

1. Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (456 reviews)
"The food is excellent quality and delicious! Friendly staff"
United States
Wendy
The price is ￥21,836
￥21,836 total
Dec 2 - Dec 3
Camino Real Hotel
A poolside area with lounge chairs and a palm tree.

2. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
Equipetrol
9.0 out of 10, Wonderful, (424 reviews)
"I love how nice and helpful staff was."
United States
Lizzie
The price is ￥23,973
￥23,973 total
Nov 9 - Nov 10
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
A modern hotel lobby with a reception desk, seating area, and a large glass wall with a sign.

3. Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Equipetrol
9.4 out of 10, Exceptional, (159 reviews)
"Good location and value for money."
United States
Hui Hua
The price is ￥5,360
￥5,360 total
Nov 20 - Nov 21
Ibis Santa Cruz DE LA Sierra
A hotel with a large swimming pool, multiple balconies, and a central arched entrance.

4. Sun Hotel

Sun Hotel
3.5 star property
Santa Cruz
8.2 out of 10, Very good, (415 reviews)
"The staff was wonderful,airport shuttle was on time, the room was very clean!!"
United States
Ivan
The price is ￥16,592
￥16,592 total
Nov 3 - Nov 4
Sun Hotel
A modern hotel lobby with a bar area, seating arrangements, and a television.

5. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (289 reviews)
"The room was very clean and the breakfast was fantastic. Overall it was a great experience."
United States
Scott
The price is ￥11,596
￥11,596 total
Nov 7 - Nov 8
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
A modern building with the sign "TRYP SANTA CRUZ" and a glass entrance with decorative lighting.

6. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Equipetrol
9.2 out of 10, Wonderful, (185 reviews)
"Beautiful hotel. Spacious room. House cleaning came every day. We got new towels every day and toiletries in the bathroom were refilled every day. Staff were friendly. View from the breakfast room was beautiful. Location of the hotel is good."
Canada
Kristina
The price is ￥15,598
￥15,598 total
Nov 4 - Nov 5
TRYP by Wyndham Santa Cruz
A spacious living area with a high ceiling, wooden beams, a staircase, and a view of a balcony.

7. Lido Hotel

Lido Hotel
3.0 star property
Centro Histórico
9.2 out of 10, Wonderful, (57 reviews)
"Lovely stay for a night. Great location within easy walking distance to the center."
United States
Gabrielle
The price is ￥3,487
￥3,487 total
Nov 5 - Nov 6
Lido Hotel
A hotel room with a large bed, bedside tables, a desk with a chair, a small refrigerator, and a TV mounted on the wall.

8. HOTEL OSHO

HOTEL OSHO
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (59 reviews)
"Room was great and staff were very accommodating!"
Canada
David
The price is ￥6,912
￥6,912 total
Nov 3 - Nov 4
HOTEL OSHO
A hotel room with a bed, bedside tables, a desk with a chair, a table with a vase of flowers, and a painting on the wall.

9. Gran Hotel Mediterráneo

Gran Hotel Mediterráneo
3.5 star property
Centro Histórico
10.0 out of 10, Exceptional, (1 review)
"Desde a recepção, a equipe da limpeza e o pessoal do café da manhã, foram sempre muito prestativos e disponíveis para ajudar no que foi necessário, voltaremos. A localização é bem próxima a praça central."
Brazil
Emerson
The price is ￥8,615
￥8,615 total
Nov 3 - Nov 4
Gran Hotel Mediterráneo
A rooftop pool with clear skies and a city view.

10. Hotel Pascana centro

Hotel Pascana centro
3.5 star property
Centro Histórico
9.4 out of 10, Exceptional, (3 reviews)
"El hotel se encuentra en el Centro histórico de la ciudad, es una estructura dentro del marco historico de la ciudad, pero se encuentra en buenas condiciones. Con facil acceso al transporte. Camina el centro de la ciudad histórica con tranquilidad."
United States
Miguel
The price is ￥10,608
￥10,608 total
Nov 10 - Nov 11
Hotel Pascana centro
A swimming pool with a water slide, surrounded by a hotel building with multiple floors and outdoor seating areas.

11. Hotel Cortez

Hotel Cortez
3.5 star property
Equipetrol
9.4 out of 10, Exceptional, (160 reviews)
"Great place to stay, with restaurants and stores nearby."
United States
Rigoberto
The price is ￥20,420
￥20,420 total
Nov 8 - Nov 9
Hotel Cortez
A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.

12. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (121 reviews)
"great place to stay!"
United States
Luisa
The price is ￥5,943
￥5,943 total
Nov 8 - Nov 9
Premium Suites Deluxe Aparthotel Equipetrol
A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

13. Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Centro Histórico
9.2 out of 10, Wonderful, (140 reviews)
"Small but beautiful and very much in the center"
United States
Rajendra
The price is ￥8,390
￥8,390 total
Nov 8 - Nov 9
Cosmopolitano Hotel Boutique
A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.

14. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (261 reviews)
"Amazing hotel"
United States
Deivis
The price is ￥19,419
￥19,419 total
Nov 14 - Nov 15
Marriott Santa Cruz de la Sierra Hotel
The exterior of the ECO HOTEL with illuminated signage and a wooden canopy.

15. Chairú Eco Hotel

Chairú Eco Hotel
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (81 reviews)
"clean close to restaurants friendly staff shop nearby overall excellent place to stay"
United States
Luis
The price is ￥7,445
￥7,445 total
Nov 11 - Nov 12
Chairú Eco Hotel
A balcony with a table set for breakfast, including a plate of fruit, a glass of orange juice, and a cup. The view includes a cityscape with buildings and a clear sky.

16. Hotel Las Américas

Hotel Las Américas
3.0 star property
Centro Histórico
8.0 out of 10, Very good, (35 reviews)
"Very clean room and great staff"
Canada
Stanley
The price is ￥3,742
￥3,742 total
Nov 23 - Nov 24
Hotel Las Américas
A hotel sign with the text "Apart Hotel Premium Suites Santa Cruz".

17. Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (107 reviews)
"Great location."
United States
Ruben
The price is ￥3,914
￥3,914 total
Nov 10 - Nov 11
Apart Hotel Premium Suites Santa Cruz
A swimming pool with a decorative center, surrounded by a building with a blue roof and a mural.

18. Gran Hotel Santa Cruz

Gran Hotel Santa Cruz
4.5 star property
Centro Histórico
The price is ￥7,812
￥7,812 total
Nov 4 - Nov 5
Gran Hotel Santa Cruz
An outdoor dining area with a brick wall, wooden shelves with plants, and a table set with plates of food and drinks.

19. Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo
3.5 star property
Equipetrol
9.4 out of 10, Exceptional, (49 reviews)
"Beautiful place, wonderful artwork"
United States
Elizabeth
The price is ￥16,985
￥16,985 total
Nov 22 - Nov 23
Alfonsina Hotel Boutique by Inboccaluppo
A spacious lobby with a high ceiling, modern furniture, and a large chandelier.

20. Hotel Arenal

Hotel Arenal
3.5 star property
Centro Histórico
7.6 out of 10, Good, (64 reviews)
"Perfect hotel in a central location!"
United States
Max
The price is ￥9,944
￥9,944 total
Dec 2 - Dec 3
Hotel Arenal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Vacation Rentals in Santa Cruz

Aparthotel
A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (121 reviews)
"great place to stay!"
Premium Suites Deluxe Aparthotel Equipetrol
See all vacation rentals

Hotels recommended for families in Santa Cruz

A modern hotel lobby with a reception desk, seating area, and a large glass wall with a sign.

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Equipetrol
9.4 out of 10, Exceptional, (159)
The price is ￥5,360
￥5,360 total
Nov 20 - Nov 21
Ibis Santa Cruz DE LA Sierra
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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Equipetrol

Though Equipetrol might not have many top sights, you can venture to the surrounding area to see attractions like Santa Cruz Zoo and Municipal Library.

Centro Histórico

If you're spending some time in Centro Histórico, Plaza 24 de Septiembre and La Recova Artisan Walk are top sights worth seeing.

Hamacas

While Hamacas isn't home to many top sights, Las Brisas Shopping Center and Santa Cruz Zoo are some notable places to visit nearby.

Zona Sur (South Zone)

Zona Sur (South Zone) might not have many top sights, but Ramon Tahuichi Aguilera Stadium and Plaza 24 de Septiembre are two attractions nearby that you can check out.

Urubó

While Urubó might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Guembe Biocenter and Ventura Mall.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
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Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
A historic cathedral with two prominent towers, surrounded by urban buildings and palm trees.

Top Santa Cruz Hotel Reviews

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

10/10 Excellent
"Habitaciones y todas las instalaciones estaban limpias, personal muy amable y atento. Ubicado en equipetrol con todo cerca"
angela 3-night trip
Posted 2 days ago
TRYP by Wyndham Santa Cruz

More cheap stays in Santa Cruz

Hotel La Sierra

Hotel La Sierra

474 Monseñor Salvatierra Santa Cruz Departamento de Santa Cruz
The price is ￥6,408 per night from Nov 10 to Nov 11
￥6,408
￥6,408 total
Nov 10 - Nov 11

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is one of the top choices for your stay based on our traveler data. This hotel offers a restaurant and free parking. Other good choices for your visit include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Marriott Santa Cruz de la Sierra Hotel. See all available top hotels, or vacation rentals in Santa Cruz.
What's the top vacation rental that Santa Cruz has to offer?
Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other homes for rent in Santa Cruz include Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveler reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Residencial Ikandire II and Nomad Hostel. View all budget hotels in Santa Cruz.
What's the best accommodation for a family trip to Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a hotel with 2 restaurants and free parking, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.
What is the top LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Hotel Pascana centro and Swissôtel Santa Cruz De La Sierra are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best pet-friendly hotel in Santa Cruz?
Casa Por Temporadas is a top dog-friendly guesthouse, and offers an outdoor pool along with in-room kitchens for its human guests. Other good options for you and your pet's trip include Ibis Santa Cruz DE LA Sierra and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.
Where is the best place to stay close to Plaza 24 de Septiembre?
Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.
What about the best place to stay near Ventura Mall?
One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.
What's the best luxury accommodation in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.
What are some accommodations with pools in Santa Cruz?
Yotau All Suites Hotel is a top hotel with 2 outdoor pools, a children's pool, and 2 restaurants. A couple of other options that offer an onsite pool include Gran Hotel Santa Cruz and Buganvillas Hotel Suites & Spa. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a top spa hotel featuring a fitness center, a hair salon, and a bar. Enjoy a facial, body scrub, or hydrotherapy at Los Tajibos Club Spa. Other popular spa hotels in Santa Cruz include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.
What's the top hotel in Santa Cruz with an on-site water park or a water park nearby?
Gran Hotel Santa Cruz is a popular hotel featuring free water park access, an outdoor pool, and a restaurant. Check out all hotels with or near waterparks in Santa Cruz.
What's the best hotel for staying near Viru Viru International Airport (VVI)?
Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.
How is it to stay in Santa Cruz?
Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 312 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What should I do while I'm visiting Santa Cruz?
Cultural venues include Ethno-folkloric Museum, Cine Center, and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Blacutt Square might be worth a visit. Natural beauty is on display at Arenal Park, Guembe Biocenter, and Lomas de Arena Regional Park. Check out what more to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.