A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Oct 23 - Oct 25
In two months
Dec 4 - Dec 6
In three months
Jan 1 - Jan 3
In four months
Jan 29 - Jan 31

Our top choices for Santa Cruz vacation rentals

A hotel sign with the text "Apart Hotel Premium Suites Santa Cruz".

1. Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (107 reviews)
"Great location."
United States
Ruben
The price is ￥4,274
￥4,274 total
Oct 13 - Oct 14
Apart Hotel Premium Suites Santa Cruz
A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.

2. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (121 reviews)
"great place to stay!"
United States
Luisa
The price is ￥7,282
￥7,282 total
Oct 18 - Oct 19
Premium Suites Deluxe Aparthotel Equipetrol
A modern hotel room with a bed, a nightstand, a lamp, a painting, a kitchen area, and a bathroom.

3. Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
2.5 star property
Santa Cruz
8.8 out of 10, Excellent, (13 reviews)
"Perfect hotel"
Turkey
Yener
The price is ￥8,139
￥8,139 total
Oct 13 - Oct 14
Equipetrol Suites Apart Hotel
A modern building with a glass facade, a pool area with sun loungers, and a clear blue sky.

4. POX: 24th Floor Green Tower | Luxury and Panoramic View

POX: 24th Floor Green Tower | Luxury and Panoramic View
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"Very comfortable and nice view and the super clean"
United States
Carlos
The price is ￥11,873
￥16,622 total
Oct 13 - Oct 14
POX: 24th Floor Green Tower | Luxury and Panoramic View
An outdoor dining area with tables and chairs, surrounded by plants and palm trees.

5. Terranova Suites

Terranova Suites
3.5 star property
Santa Cruz
8.0 out of 10, Very good, (91 reviews)
"Easy to access"
United States
Dorothy
The price is ￥8,218
￥8,218 total
Oct 13 - Oct 14
Terranova Suites
A modern rooftop pool with a city view, wooden flooring, and a seating area.

6. AMERICA APARTMENTS

AMERICA APARTMENTS
3.0 star property
Santa Cruz
10.0 out of 10, Exceptional, (3 reviews)
"Clean room, great staff "
Canada
Peter
The price is ￥5,414
￥5,414 total
Oct 13 - Oct 14
AMERICA APARTMENTS
A hotel with multiple floors, a pool area with lounge chairs, and palm trees.

7. Apart Hotel Toborochi

Apart Hotel Toborochi
3.0 star property
Equipetrol
8.8 out of 10, Excellent, (61 reviews)
"Very comfortable and quiet place and very good location. "
United States
Luis
The price is ￥11,541
￥11,541 total
Nov 1 - Nov 2
Apart Hotel Toborochi
A modern kitchen with dark cabinetry, a dining area with a black table and chairs, and a living room with a sofa and a large abstract painting.

8. Aqua: Loft Artistico Urbano

Aqua: Loft Artistico Urbano
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"Excellent atencion todo muy comodo bonito limpio gracias"
United States
Nestor C.
The price is ￥4,749
￥10,765 total
Oct 13 - Oct 14
Aqua: Loft Artistico Urbano
A rooftop swimming pool with a clear view of the city skyline and a partly cloudy sky.

9. Menacho Apartment - Mangales Blue - Norte

Menacho Apartment - Mangales Blue - Norte
Santa Cruz de la Sierra
The price is ￥3,651
￥5,238 total
Oct 13 - Oct 14
Menacho Apartment - Mangales Blue - Norte
A rooftop pool with lounge chairs and a cityscape view at sunset.

10. Apartment with balcony, swimming pool, gym, co-work at Equipe

Apartment with balcony, swimming pool, gym, co-work at Equipe
Equipetrol
The price is ￥4,116
￥8,707 total
Oct 19 - Oct 20
Apartment with balcony, swimming pool, gym, co-work at Equipe
A rooftop pool with lounge chairs and a cityscape view at sunset.

11. Dpt TV 58" / Swimming pool / Cowork / Gym / Queen Bed

Dpt TV 58" / Swimming pool / Cowork / Gym / Queen Bed
Equipetrol
8.0 out of 10, Very good, (2 reviews)
The price is ￥3,989
￥8,580 total
Oct 13 - Oct 14
Dpt TV 58" / Swimming pool / Cowork / Gym / Queen Bed
A modern kitchen with a stainless steel refrigerator, a wooden door, and a dining area with a table set for two.

12. Comfort in the best area of Santa Cruz—perfect for business travelers and tourists!!

Comfort in the best area of Santa Cruz—perfect for business travelers and tourists!!
Santa Cruz de la Sierra
The price is ￥4,078
￥9,043 total
Oct 18 - Oct 19
Comfort in the best area of Santa Cruz—perfect for business travelers and tourists!!
A modern office space with glass walls, a long table with chairs, and several round ottomans.

13. Enchanting studio with AC in Santa Cruz de la Sierra

Enchanting studio with AC in Santa Cruz de la Sierra
Equipetrol
The price is ￥4,274
￥7,440 total
Oct 13 - Oct 14
Enchanting studio with AC in Santa Cruz de la Sierra
A rooftop pool with lounge chairs and a cityscape view at sunset.

14. Dpt. with Work Area / Swimming Pool / Gym / Sofa Bed

Dpt. with Work Area / Swimming Pool / Gym / Sofa Bed
Equipetrol
The price is ￥4,116
￥8,707 total
Oct 19 - Oct 20
Dpt. with Work Area / Swimming Pool / Gym / Sofa Bed
A modern outdoor kitchen area with a built-in oven, seating, and a view of the city skyline.

15. COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!
Equipetrol
The price is ￥6,332
￥10,606 total
Oct 13 - Oct 14
COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!
A rooftop pool with clear blue water, surrounded by lounge chairs and potted plants.

16. 1 bedroom apartment, 2 TVs, 2 A/Cs, swimming pool & cowork

1 bedroom apartment, 2 TVs, 2 A/Cs, swimming pool & cowork
Equipetrol
The price is ￥4,433
￥9,024 total
Oct 19 - Oct 20
1 bedroom apartment, 2 TVs, 2 A/Cs, swimming pool & cowork
A modern kitchen with a stainless steel sink, a microwave, and a kettle.

17. Complete apartment in the best location in Santa Cruz, 5 min from Manzana 40.

Complete apartment in the best location in Santa Cruz, 5 min from Manzana 40.
Santa Cruz de la Sierra
The price is ￥5,586
￥8,778 total
Oct 13 - Oct 14
Complete apartment in the best location in Santa Cruz, 5 min from Manzana 40.
A rooftop pool with clear blue water, surrounded by palm trees and a cityscape in the background.

18. Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC

Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC
Equipetrol
The price is ￥3,562
￥7,520 total
Oct 24 - Oct 25
Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC
A spacious kitchen with a large island, modern design, and a view of the water.

19. Total Comfort in Santa Cruz

Total Comfort in Santa Cruz
Santa Cruz de la Sierra
The price is ￥3,958
￥7,441 total
Oct 29 - Oct 30
Total Comfort in Santa Cruz
A rooftop pool with clear blue water, surrounded by lounge chairs and potted plants.

20. Inspiring views • Enveloping comfort

Inspiring views • Enveloping comfort
Equipetrol
The price is ￥4,591
￥8,707 total
Oct 19 - Oct 20
Inspiring views • Enveloping comfort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Hotel Cortez

Hotel Cortez

10/10 Excellent
"Most amazing hotel staff ever. Thanks for making this a special stay. good food, but the staff goes the extra mile to make it special. Gracias!!"
Fabio 7-night trip
Posted 1 day ago
Hotel Cortez

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we have vacation rentals in Santa Cruz near Santa Cruz Zoo, or you can go with a secluded option if you're looking for a relaxing stay. Discover why Santa Cruz is known for its shops. Make sure you have time to check out the cafes and zoo during your trip.

What are some of the best vacation home rentals in Santa Cruz?

Casa Vida: This highly rated vacation home rental in Santa Cruz is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other top choices in Santa Cruz are Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House.

How many vacation rentals will I find in Santa Cruz?

With 23 Expedia vacation rentals, you're sure to find just the right place for your Santa Cruz stay.

What can I see and do in Santa Cruz?

Enjoy the outdoors at Arenal Park and Guembe Biocenter, or simply take in cultural attractions like Ethno-folkloric Museum and Cine Center. Plaza 24 de Septiembre and Blacutt Square are other places to visit while you're in town.

What are vacation rentals like in Santa Cruz?

Vacation rentals are private accommodations you can stay in for several days or more in Santa Cruz. Vacation rentals provide amenities such as laundry facilities and kitchens so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy reception areas while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family trip.