A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz Vacation Rentals

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Our top choices for Santa Cruz vacation rentals

Curupau | Modern 1-Bedroom Apartment with Pool & Parking

Curupau | Modern 1-Bedroom Apartment with Pool & Parking
Santa Cruz de la Sierra
The price is ¥4,365
¥7,599 total
Jul 14 - Jul 15
Curupau | Modern 1-Bedroom Apartment with Pool & Parking

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
2.5 star property
Santa Cruz
8.8 out of 10, Excellent, (13 reviews)
"Perfect hotel"
Turkey
Yener
The price is ¥8,035
¥8,035 total
Jul 12 - Jul 13
Equipetrol Suites Apart Hotel

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (109 reviews)
"Great Location"
United States
Blanca
The price is ¥7,437
¥7,437 total
Jul 14 - Jul 15
Premium Suites Deluxe Aparthotel Equipetrol

Terranova Suites

Terranova Suites
3.5 star property
Santa Cruz
8.0 out of 10, Very Good, (91 reviews)
"Easy to access"
United States
Dorothy
The price is ¥8,393
¥8,393 total
Jul 12 - Jul 13
Terranova Suites

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (102 reviews)
"Great location."
United States
Ruben
The price is ¥4,365
¥4,365 total
Jul 13 - Jul 14
Apart Hotel Premium Suites Santa Cruz

AMERICA APARTMENTS

AMERICA APARTMENTS
3.0 star property
Santa Cruz
10.0 out of 10, Exceptional, (2 reviews)
"Clean room, great staff "
Canada
Peter
The price is ¥5,530
¥5,530 total
Aug 1 - Aug 2
AMERICA APARTMENTS

Tranquil apartment with WiFi in Santa Cruz de la Sierra

Tranquil apartment with WiFi in Santa Cruz de la Sierra
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (2 reviews)
"Zona tranquila y todo cerca supermercados tiendas etc"
Mexico
Fabricio O.
The price is ¥6,467
¥9,701 total
Jul 12 - Jul 13
Tranquil apartment with WiFi in Santa Cruz de la Sierra

Casa de 2 Habitaciones en zona norte

Casa de 2 Habitaciones en zona norte
Santa Cruz de la Sierra
8.0 out of 10, Very Good, (1 review)
"Muy buen departamento, bien ubicado"
United States
Elva
The price is ¥6,306
¥9,540 total
Aug 8 - Aug 9
Casa de 2 Habitaciones en zona norte

Casa Vida

Casa Vida
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (2 reviews)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"
Chile
FERNANDO
The price is ¥14,667
¥14,667 total
Aug 11 - Aug 12
Casa Vida

POX: 24th Floor Green Tower | Luxury and Panoramic View

POX: 24th Floor Green Tower | Luxury and Panoramic View
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"Very comfortable and nice view and the super clean"
United States
Carlos
The price is ¥12,126
¥16,976 total
Jul 12 - Jul 13
POX: 24th Floor Green Tower | Luxury and Panoramic View

Apart Hotel Toborochi

Apart Hotel Toborochi
3.0 star property
Santa Cruz
8.8 out of 10, Excellent, (60 reviews)
"Very comfortable and quiet place and very good location. "
United States
Luis
The price is ¥21,827
¥21,827 total
Jul 12 - Jul 13
Apart Hotel Toborochi

Santos Apartamentos

Santos Apartamentos
3.5 star property
Santa Cruz
The price is ¥17,025
¥21,875 total
Jul 17 - Jul 18
Santos Apartamentos

POX: Green Tower 16th floor : Luxury and elegance - 2H

POX: Green Tower 16th floor : Luxury and elegance - 2H
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"Beautiful place, excellent location."
United States
Ruben
The price is ¥14,551
¥17,785 total
Jul 12 - Jul 13
POX: Green Tower 16th floor : Luxury and elegance - 2H

Total Comfort in Santa Cruz

Total Comfort in Santa Cruz
Santa Cruz de la Sierra
The price is ¥3,638
¥7,195 total
Jul 19 - Jul 20
Total Comfort in Santa Cruz

Dpt TV 58" / Swimming pool / Cowork / Gym / Queen Bed

Dpt TV 58" / Swimming pool / Cowork / Gym / Queen Bed
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
The price is ¥4,527
¥9,216 total
Aug 10 - Aug 11
Dpt TV 58" / Swimming pool / Cowork / Gym / Queen Bed

Cozy and independent.<br>Downtown house JH.

Cozy and independent.<br>Downtown house JH.
Santa Cruz de la Sierra
The price is ¥5,093
¥8,327 total
Jul 14 - Jul 15
Cozy and independent.<br>Downtown house JH.

Menacho Apartment - Mangales Blue - Norte

Menacho Apartment - Mangales Blue - Norte
Santa Cruz de la Sierra
The price is ¥3,640
¥5,254 total
Aug 8 - Aug 9
Menacho Apartment - Mangales Blue - Norte

Charming 1-bedroom apartment in brilliant Santa Cruz with AC, WiFi

Charming 1-bedroom apartment in brilliant Santa Cruz with AC, WiFi
Santa Cruz de la Sierra
The price is ¥3,557
¥7,922 total
Aug 8 - Aug 9
Charming 1-bedroom apartment in brilliant Santa Cruz with AC, WiFi

Enchanting studio with AC in Santa Cruz de la Sierra

Enchanting studio with AC in Santa Cruz de la Sierra
Santa Cruz de la Sierra
The price is ¥4,850
¥8,084 total
Aug 10 - Aug 11
Enchanting studio with AC in Santa Cruz de la Sierra

1-bedroom Modern Apartment in Sirari, Equipetrol

1-bedroom Modern Apartment in Sirari, Equipetrol
Santa Cruz de la Sierra
The price is ¥4,365
¥8,035 total
Jul 16 - Jul 17
1-bedroom Modern Apartment in Sirari, Equipetrol
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

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Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we have vacation rentals in Santa Cruz near Santa Cruz Zoo, or you can go with a secluded option if you're looking for a relaxing stay. Discover why Santa Cruz is known for its shops. Make sure you have time to check out the cafes and zoo during your trip.

What are some of the best vacation home rentals in Santa Cruz?

Casa Vida: This highly rated vacation home rental in Santa Cruz is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other top choices in Santa Cruz are Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House.

How many vacation rentals will I find in Santa Cruz?

With 22 Expedia vacation rentals, you're sure to find just the right place for your Santa Cruz stay.

What can I see and do in Santa Cruz?

Enjoy the outdoors at Arenal Park and Guembe Biocenter, or simply take in cultural attractions like Cine Center and Ethno-folkloric Museum. Plaza 24 de Septiembre and Blacutt Square are other places to visit while you're in town.

What are vacation rentals like in Santa Cruz?

Vacation rentals are private accommodations you can stay in for several days or more in Santa Cruz. Vacation rentals provide amenities such as laundry facilities and kitchens so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy reception areas while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family trip.