A colonial-style building with a bell tower, palm trees, and a paved walkway.

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Check prices for these dates

Next weekend
Jul 17 - Jul 19
In two weeks
Jul 24 - Jul 26

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Our top choices for Santa Cruz hotels

Seasonal outdoor pool

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (385 reviews)
"Nice hotel"
United States
Mabel Marisel
The price is ￥20,477
￥20,477 total
Jul 22 - Jul 23
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Miscellaneous

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Santa Cruz
9.4 out of 10, Exceptional, (124 reviews)
"Nice place"
United States
Juan Carlos
The price is ￥8,643
￥8,643 total
Jul 30 - Jul 31
Ibis Santa Cruz DE LA Sierra
Outdoor pool, pool umbrellas, sun loungers

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (236 reviews)
"Amazing hotel"
United States
Deivis
The price is ￥19,837
￥19,837 total
Jul 24 - Jul 25
Marriott Santa Cruz de la Sierra Hotel
Reception

Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (433 reviews)
"Definitely I would’ve recommend anybody who is looking for hotel because the service was excellent make me feel special since I walked in into the place and also I was impressed how clean the place was…Thanks for the service guys…Keep up this way..thanks again for everything…I’ll see you soon.🙏"
United States
Edwin
The price is ￥23,457
￥23,457 total
Aug 5 - Aug 6
Camino Real Hotel
Outdoor pool, sun loungers

Hotel Cortez

Hotel Cortez
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (144 reviews)
"Lovely hotel. Great room, location, staff and amenities. "
Norway
Solvei Emily Brekke
The price is ￥19,790
￥19,790 total
Jul 17 - Jul 18
Hotel Cortez
Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (109 reviews)
"Great Location"
United States
Blanca
The price is ￥7,437
￥7,437 total
Jul 14 - Jul 15
Premium Suites Deluxe Aparthotel Equipetrol
Lounge

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (279 reviews)
"The hotel truly exceeded all my expectations. The quality of the facilities, the service, and the excellent breakfast were outstanding."
United States
imilse de
The price is ￥11,900
￥11,900 total
Aug 1 - Aug 2
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Outdoor pool

Sun Hotel

Sun Hotel
3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (385 reviews)
"Very well located three start hotel. Clean with everything you need for an in/out night. Hotel needs a redoing."
United States
jose
The price is ￥17,461
￥17,461 total
Jul 16 - Jul 17
Sun Hotel
Outdoor pool

Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (95 reviews)
"Great location, nice and quiet neighborhood."
United States
ALEJANDRO
The price is ￥7,712
￥7,712 total
Jul 30 - Jul 31
Delfines Collection Hotel By Mercure
Exterior detail

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (166 reviews)
"My go too hotel whenever I'm in town! "
United States
Pluetina
The price is ￥15,861
￥15,861 total
Jul 13 - Jul 14
TRYP by Wyndham Santa Cruz
Front of property

Chairú Eco Hotel

Chairú Eco Hotel
3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (69 reviews)
"Clean room and friendly staff "
United States
marcia
The price is ￥8,730
￥8,730 total
Jul 12 - Jul 13
Chairú Eco Hotel
Honeymoon Room, 1 King Bed | Egyptian cotton sheets, premium bedding, pillowtop beds, minibar

HOTEL OSHO

HOTEL OSHO
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (52 reviews)
"Room was great and staff were very accommodating!"
Canada
David
The price is ￥7,542
￥9,967 total
Jul 19 - Jul 20
HOTEL OSHO
Lobby sitting area

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (119 reviews)
"REALLY NICE HOTEL. STAFF WONDERFULL"
United States
ERNESTO
The price is ￥21,439
￥21,439 total
Aug 3 - Aug 4
Novotel Santa Cruz De La Sierra
Front of property

Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (45 reviews)
"Beautiful place, wonderful artwork"
United States
Elizabeth
The price is ￥17,232
￥17,232 total
Jul 15 - Jul 16
Alfonsina Hotel Boutique by Inboccaluppo
Reception

Lido Hotel

Lido Hotel
3.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (45 reviews)
"Lovely stay for a night. Great location within easy walking distance to the center."
United States
Gabrielle
The price is ￥5,366
￥5,366 total
Jul 19 - Jul 20
Lido Hotel
Massages

Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (87 reviews)
"Great room, spacious, quiet and the shower was great"
United States
GONZALO
The price is ￥16,272
￥16,272 total
Jul 26 - Jul 27
Swissôtel Santa Cruz De La Sierra
Daily buffet breakfast for a fee

Hotel LP Equipetrol

Hotel LP Equipetrol
3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (209 reviews)
"Nice place to stay"
United States
Ricardo
The price is ￥6,351
￥7,159 total
Jul 12 - Jul 13
Hotel LP Equipetrol
Terrace/patio

Hotel Las Américas

Hotel Las Américas
3.0 star property
Santa Cruz
8.0 out of 10, Very Good, (19 reviews)
"Very clean room and great staff"
Canada
Stanley
The price is ￥5,592
￥5,592 total
Jul 12 - Jul 13
Hotel Las Américas
Premium Room, 1 Queen Bed, Bathtub | Minibar, in-room safe, individually decorated, individually furnished

Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (133 reviews)
"Everything was excellent! Clean room, delicious food, friendly staff, great location!"
United States
Heidi
The price is ￥14,681
￥14,681 total
Jul 18 - Jul 19
Cosmopolitano Hotel Boutique
Standard Room, 2 Twin Beds | Premium bedding, minibar, in-room safe, desk

Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro
3.0 star property
Santa Cruz
8.0 out of 10, Very Good, (285 reviews)
"Awesome hotel "
Canada
John
The price is ￥7,856
￥8,664 total
Jul 13 - Jul 14
Hotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Vacation Rentals in Santa Cruz

Aparthotel
Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (109 reviews)
Premium Suites Deluxe Aparthotel Equipetrol
See all vacation rentals
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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Hamacas

While Hamacas isn't home to many top sights, Santa Cruz Zoo and Las Brisas Shopping Center are some notable places to visit nearby.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
See properties

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
A colonial-style building with a bell tower, palm trees, and a paved walkway.

Top Santa Cruz Hotel Reviews

Hotel Las Américas

Hotel Las Américas

10/10 Excellent
"Lo mejor es la ubicación"
José 3-night trip
Posted 2 days ago
Hotel Las Américas

More cheap stays in Santa Cruz

Ibiza Hostel

Ibiza Hostel

445 Santa Cruz Departamento de Santa Cruz
The price is ￥2,037 per night from Jul 12 to Jul 13
￥2,037
￥4,301 total
Jul 12 - Jul 13

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is one of the top choices for your stay based on our traveler data. This hotel offers a restaurant and free parking. Other good choices for your visit include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Marriott Santa Cruz de la Sierra Hotel. See all available top hotels, or vacation rentals in Santa Cruz.
What's the top vacation rental that Santa Cruz has to offer?
Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other homes for rent in Santa Cruz include Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveler reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Ibiza Hostel and Nomad Hostel. View all budget hotels in Santa Cruz.
What's the best accommodation for a family trip to Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a hotel with 2 restaurants and free parking, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.
What is the top LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best pet-friendly hotel in Santa Cruz?
Casa Por Temporadas is a top dog-friendly guesthouse, and offers an outdoor pool along with in-room kitchens for its human guests. Other good options for you and your pet's trip include Ibis Santa Cruz DE LA Sierra and Swissôtel Santa Cruz De La Sierra. See more pet-friendly hotel accommodations in Santa Cruz.
Where is the best place to stay close to Plaza 24 de Septiembre?
Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.
What about the best place to stay near Ventura Mall?
One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.
What's the best luxury accommodation in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Novotel Santa Cruz De La Sierra are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.
What are some accommodations with pools in Santa Cruz?
Yotau All Suites Hotel is a top hotel with 2 outdoor pools, a children's pool, and 2 restaurants. A couple of other options that offer an onsite pool include Buganvillas Hotel Suites & Spa and Loft sobrio, rooftop panorámico y piscina infinita. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a top spa hotel featuring a fitness center, a hair salon, and a bar. Enjoy a facial, body scrub, or hydrotherapy at Los Tajibos Club Spa. Other popular spa hotels in Santa Cruz include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.
What's the best hotel for staying near Viru Viru International Airport (VVI)?
Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.
How is it to stay in Santa Cruz?
Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 292 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What should I do while I'm visiting Santa Cruz?
Cultural venues include Cine Center, Ethno-folkloric Museum, and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Blacutt Square might be worth a visit. Natural beauty is on display at Arenal Park, Guembe Biocenter, and Lomas de Arena Regional Park. Check out what more to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.