What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 7 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Top Sanctuary Hotels

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Our top choices for Sanctuary hotels

1. Cape Coral Retreat w Pool & Court

24.2 km from Sanctuary

￥64,846 total

includes taxes & fees

Aug 26 - Aug 27

2. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

Adainis

￥54,797 total

includes taxes & fees

Aug 26 - Aug 27

3. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Juliana

￥12,703 total

includes taxes & fees

Aug 30 - Aug 31

4. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

Tom

￥17,901 total

includes taxes & fees

Sep 20 - Sep 21

5. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

30.1 km from Sanctuary

Melissa

￥13,973 total

includes taxes & fees

Aug 28 - Aug 29

6. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Laura

￥15,880 total

includes taxes & fees

Aug 22 - Aug 23

7. Allure Suites

27.2 km from Sanctuary

Brian

￥11,150 total

includes taxes & fees

Aug 26 - Aug 27

8. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

22.9 km from Sanctuary

Daveanand

￥14,323 total

includes taxes & fees

Aug 27 - Aug 28

9. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

25.2 km from Sanctuary

Donna

￥9,460 total

includes taxes & fees

Aug 26 - Aug 27

10. Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

Suzanna

￥16,796 total

includes taxes & fees

Aug 28 - Aug 29

11. Homewood Suites by Hilton - Fort Myers

30.9 km from Sanctuary

Kirk

￥17,216 total

includes taxes & fees

Aug 27 - Aug 28

12. Candlewood Suites Fort Myers Sanibel Gateway by IHG

25.4 km from Sanctuary

Bret

￥11,821 total

includes taxes & fees

Aug 30 - Aug 31

13. Doubletree by Hilton Fort Myers at Bell Tower Shops

30.8 km from Sanctuary

heather

￥16,568 total

includes taxes & fees

Sep 6 - Sep 7

14. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

23.1 km from Sanctuary

Lilia

￥16,407 total

includes taxes & fees

Aug 26 - Aug 27

15. Sanibel Inn

East End, 13.8 km from Sanctuary

William

￥59,805 total

includes taxes & fees

Aug 24 - Aug 25

16. Shalimar Beach Resort

West End, 10.3 km from Sanctuary

Aldo

￥35,685 total

includes taxes & fees

Aug 23 - Aug 24

Floating Coconut Cottage Houseboat | Terrace/patio

17. Latitude 26 Waterfront Resort & Marina

22 km from Sanctuary

Rick

￥25,659 total

includes taxes & fees

Aug 31 - Sep 1

18. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

22.6 km from Sanctuary

Taylor

￥15,896 total

includes taxes & fees

Aug 27 - Aug 28

19. Sundial Beach Resort & Spa

Mid Island, 12.8 km from Sanctuary

moti

￥79,039 total

includes taxes & fees

Aug 23 - Aug 24

20. Marriott Sanibel Harbour Resort & Spa

15.6 km from Sanctuary

Scott

￥39,271 total

includes taxes & fees

Sep 6 - Sep 7

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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

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Top Sanctuary Hotel Reviews

Pink Shell Beach Resort and Marina

10/10 Excellent

"Great location, great staff. Loved it all"

Margaritaville Beach Resort Fort Myers

10/10 Excellent

"Honestly this was the cleanest with the most polite best service with all the amenities you could ask for. Best resort I've ever stayed at and will definitely be back. If I could find 1 downfall I'm not a huge fan of check in being a floor up when you're unloading bags etc. That part could be more smooth."

Marriott Sanibel Harbour Resort & Spa

8/10 Good

"The check in process was quick and were given 2 welcome drink passes for the bar which was great. The problem was the elevators which only 2 were operational and took anywhere from 3-9min just to go floor by floor at any given moment.the restaurants were a bit expensive but still gaave it a try. The spa is definitely recommended as well as the gym which is very stocked. The pools was nice and never crowded. The bimini restaurant which is a small golf cart drive away is very recommended. The height of the stay were the amazing sunsets by the poolside which were incredible. Overall the stay was good, but try it out . Enjoy!"

The Lighthouse Resort Inn & Suites

10/10 Excellent

"Everything about this resort was amazing. The suite was immaculately cling the staff was very helpful very friendly. The food was tasty the breakfast lunch and dinner plus the wings. Amazing drinks were on point. The amenities were easy to access, relaxing. This is my go to spot whenever I go to Fort Myers this is a must visit spot. Everything is right there. You’re in a prime location."

Find hotels in Sanctuary, Sanibel

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Our top choices for Sanctuary hotels

1. Cape Coral Retreat w Pool & Court

2. Tween Waters Island Resort & Spa

3. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

4. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

5. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

6. Residence Inn by Marriott Fort Myers Sanibel

7. Allure Suites

8. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

9. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

10. Hilton Garden Inn Ft Myers

11. Homewood Suites by Hilton - Fort Myers

12. Candlewood Suites Fort Myers Sanibel Gateway by IHG

13. Doubletree by Hilton Fort Myers at Bell Tower Shops

14. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

15. Sanibel Inn

16. Shalimar Beach Resort

17. Latitude 26 Waterfront Resort & Marina

18. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

19. Sundial Beach Resort & Spa

20. Marriott Sanibel Harbour Resort & Spa

Where to stay in Sanctuary

Mid Island

West End

East End

Beachview Country Club Estates

Gulf Shores

Top Sanctuary Hotel Reviews

Pink Shell Beach Resort and Marina

Frequently asked questions

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