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Discover 1,523 San Antonio hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for San Antonio hotels

Hyatt Regency Panama City
Restaurant

Hyatt Regency Panama City

4.5 star property
10.0 out of 10, Exceptional, (73)
"Great service & clean room throughout stay"
The price is ￥24,680
￥27,148 total
includes taxes & fees
Sep 27 - Sep 28
Hyatt Regency Panama City
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Suite, 1 Bedroom, Non Smoking, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
9.6 out of 10, Exceptional, (608)
"Staff was lovely - especially front desk, door staff, cleaning team and room service. Only critique is that service was very slow in the restaurant both times but otherwise a lovely visit. "
The price is ￥31,976
￥35,174 total
includes taxes & fees
Oct 3 - Oct 4
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Gran Evenia Panama
Outdoor pool, sun loungers

Gran Evenia Panama

4.5 star property
9.2 out of 10, Wonderful, (182)
"Excellent hotel and staff."
Gran Evenia Panama
Panama House Bed & Breakfast
Terrace/patio

Panama House Bed & Breakfast

2.5 star property
9.0 out of 10, Wonderful, (172)
"Was amazing the host and the people there was super friendly and welcoming. Also has amazing local food spots within walking distance."
Panama House Bed & Breakfast
TRYP by Wyndham Panamá Centro
Exterior

TRYP by Wyndham Panamá Centro

3.5 star property
9.2 out of 10, Wonderful, (1014)
"I will recommend anyone to stay here. "
The price is ￥12,045
￥13,249 total
includes taxes & fees
Sep 26 - Sep 27
TRYP by Wyndham Panamá Centro
Hotel San Felipe
Front of property

Hotel San Felipe

4.0 star property
9.4 out of 10, Exceptional, (205)
"It’s in the heart of the city, great place to stay "
The price is ￥18,632
￥20,495 total
includes taxes & fees
Sep 29 - Sep 30
Hotel San Felipe
Toscana Inn
Exterior

Toscana Inn

3.5 star property
9.0 out of 10, Wonderful, (721)
"Great hotel"
Toscana Inn
Renaissance Panama City Hotel
40-inch Smart TV with cable channels, TV

Renaissance Panama City Hotel

5.0 star property
9.0 out of 10, Wonderful, (63)
"The Room was very clean, all staff were very kind and professional, the breakfast and dinner are so delicious, nothing comparative with other restaurant around. "
The price is ￥15,204
￥16,724 total
includes taxes & fees
Oct 4 - Oct 5
Renaissance Panama City Hotel
Hotel Milan
Exterior

Hotel Milan

3.0 star property
9.0 out of 10, Wonderful, (397)
"I enjoyed my stay "
The price is ￥5,904
￥6,494 total
includes taxes & fees
Sep 25 - Sep 26
Hotel Milan
Arcadia Condo Suites
50-inch LED TV with satellite channels

Arcadia Condo Suites

2.5 star property
9.4 out of 10, Exceptional, (79)
"Comfortable & good location"
The price is ￥8,237
￥15,881 total
includes taxes & fees
Oct 1 - Oct 2
Arcadia Condo Suites
Bristol Panama, a Registry Collection Hotel
Couples treatment rooms, sauna, steam room, body treatments

Bristol Panama, a Registry Collection Hotel

5.0 star property
9.2 out of 10, Wonderful, (1012)
"We had an amazing time, great hotel and great breakfast. "
The price is ￥26,016
￥28,618 total
includes taxes & fees
Oct 24 - Oct 25
Bristol Panama, a Registry Collection Hotel
The Executive Hotel
Lobby

The Executive Hotel

3.5 star property
9.2 out of 10, Wonderful, (1017)
"Good place to stay! "
The Executive Hotel
Hotel Riu Plaza Panama
Outdoor pool, sun loungers

Hotel Riu Plaza Panama

5.0 star property
9.0 out of 10, Wonderful, (4319)
"Really nice hotel With very good breakfast options "
The price is ￥17,515
￥19,267 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Riu Plaza Panama
Best Western Plus Panama Zen Hotel
Outdoor pool, pool umbrellas, sun loungers

Best Western Plus Panama Zen Hotel

4.0 star property
9.0 out of 10, Wonderful, (940)
"The staff was very nice love to stay every time I go home "
The price is ￥11,715
￥12,886 total
includes taxes & fees
Oct 25 - Oct 26
Best Western Plus Panama Zen Hotel
Novotel Panama City
Front of property

Novotel Panama City

4.0 star property
9.0 out of 10, Wonderful, (1020)
"The Staff were all welcoming location was very convenient I highly recommend "
The price is ￥14,776
￥16,254 total
includes taxes & fees
Oct 15 - Oct 16
Novotel Panama City
Waymore Hotel Spa & Casino
Outdoor pool

Waymore Hotel Spa & Casino

4.0 star property
9.0 out of 10, Wonderful, (498)
"I like the hotel, clean room, a lot of restaurants around it "
The price is ￥13,285
￥14,613 total
includes taxes & fees
Oct 4 - Oct 5
Waymore Hotel Spa & Casino
Hotel Coral Suites
Reception

Hotel Coral Suites

3.5 star property
9.0 out of 10, Wonderful, (1003)
"Great location with spacious rooms "
The price is ￥10,229
￥11,252 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Coral Suites
Las Clementinas
Studio, 1 King Bed, Non Smoking, Connecting Rooms | Premium bedding, in-room safe, individually decorated

Las Clementinas

3.5 star property
9.4 out of 10, Exceptional, (162)
"Great Food , excellent bar.... soft beds and pillows.... five stars will come again !"
The price is ￥17,314
￥19,045 total
includes taxes & fees
Sep 29 - Sep 30
Las Clementinas
Sofitel Legend Casco Viejo, Panama City
Exterior

Sofitel Legend Casco Viejo, Panama City

5.0 star property
9.8 out of 10, Exceptional, (509)
"Great stay"
The price is ￥43,176
￥47,494 total
includes taxes & fees
Oct 1 - Oct 2
Sofitel Legend Casco Viejo, Panama City
Principe Hotel and Suites
Front of property - evening/night

Principe Hotel and Suites

3.0 star property
9.0 out of 10, Wonderful, (1490)
"Great place to stay"
The price is ￥7,346
￥8,081 total
includes taxes & fees
Oct 3 - Oct 4
Principe Hotel and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most.

Cerro Viento

Shopping and restaurants are notable features of Cerro Viento. You might consider a stop by Metromall Panama while you're exploring the neighborhood.

Amelia Denis de Icaza

Amelia Denis de Icaza might not have many top sights, but El Dorado Mall and Panama Viejo are two attractions nearby that you can check out.

Rufina Alfaro

If you're looking for some top things to see and do in Rufina Alfaro and surrounding area, you can visit Metromall Panama and Los Pueblos Commercial Center.

Victoriano Lorenzo

Though Victoriano Lorenzo might not have many top sights, you can venture to the surrounding area to see attractions like Panama Viejo and Estadio Rommel Fernandez.

Los Andes

While there might not be top attractions in Los Andes, you can explore the larger area and discover places like Estadio Rommel Fernandez and El Dorado Mall.

Top San Antonio Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"The Riu Plaza was great for the accomadatioms. We had a little mix up with booking in the beginning but they were really professional about it and got it handled. The Pool area was clean and nice to hang out at. The breakfast included was GREAT. The 3 restaurants were great also and the food from Ibiza outside dining for dinner was excellent. The staff were very friendly and helpful. The location of Rui was perfect and very Uber friendly. The view from the Hotel of on the right floor was excellent as well . I would recommend this spot to anyone coming to visit Panamá City. "
Antoine 4-night trip
Posted 3 days ago
Hotel Riu Plaza Panama

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Frequently asked questions

What's it like in San Antonio?

San Antonio is a neighborhood that travelers like for its shopping and gardens.

If I need to cancel my hotel reservation in San Antonio, will I receive a refund?

Yes, most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to get the best deals in San Antonio.

Where can I learn more about changing or cancelling my trip to San Antonio?

To find more details about rescheduling or cancelling your trip to San Antonio, click here.

What is there to do in this San Miguelito neighborhood?

Metromall Panama, Los Pueblos Commercial Center, and Estadio Rommel Fernandez are just a few of the places to visit in and around San Antonio. While you're out sightseeing, Plaza de Francia and Atrio Mall are a couple of additional sights to visit in San Miguelito.