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This area of Rome has around 2,300,000 residents.
Start off your trip at the iconic St. Peter's Basilica and Roman Forum.
Escape the adult world for a while and throw yourself into a place of imagination and wonder at Rainbow MagicLand and Zoomarine. If you're on the lookout for even more family fun, head onwards to the Explora Children's Museum and Hydromania.
Your family doesn't need to have gills and scales in order to enjoy the deep waters at Mediterraneum Aquarium Rome.
The little ones could spend a whole day zipping around and looking over the wide range of species at the Bioparco di Roma and the Zoo Marine.
There's not many things more pleasurable than a divine glass of wine. Taste the region's latest vintages at Fontana Candida or the Gotto D'Oro-Cantina Sociale di Marino. Afterwards, if you have sufficient time, also think about the La Luna del Casale and the Rutuli Vineyard.
From alluring plants to winding garden pathways, the treasures of the Botanical Gardens are just waiting to be discovered. Many travelers also like to take a leisurely stroll around the Orto Botanico and the Municipal Rose Garden.
Pack a picnic basket and enjoy some time to yourself in the tranquil surroundings of Villa Borghese and the Vatican Gardens. You'll also find plenty of room to laze about at Lake Albano and Villa Torlonia.
See if you can spot some of the local birdlife with a visit to one of the region's lakes, such as Lake Nemi or Tiber River.
Leave your phone in the glove compartment and have a break from the modern world at Baths of Caracalla and Lupercale. Parco della Caffarella and Parco Archeologico Appia Antica are also popular among nature lovers.
See the world from a different perspective by spending some time at one of the area's well-curated cultural institutions. The Capitoline Museum and the Vatican Museums offer a range of collections that are sure to capture your interest. The MAXXI - National Museum of the 21st Century and the Museum of Roman Civilization are also worthwhile.
Stories of this area's maritime history are imprinted on the remains of old vessels on display at the Museo delle Navi Romani.
Featuring a large array of scientific objects and displays, Rome Observatory is worth spending some time at.
From the moment you walk through the doors, it is plain to see that the collections at the Crypta Balbi and the Ara Pacis are the product of an obsession. Staring back from behind protective glass, these fantastic specimens are sure to spark your imagination. The Museo delle Navi Romane and the Museo delle Mura are also well worth a visit.
A haven for art aficionados, this area boasts numerous spaces in which amateurs and professionals regularly display their work. Start your explorations of this creative enclave with a stop at the Castel Sant'Angelo and the National Gallery of Modern Art. The Borghese Gallery and the Galleria Doria Pamphilj are also well worth a browse if your schedule allows.
Nostalgics can rediscover the past at the Trajan's Market and the Montemartini Museum. The Central Museum of the Risorgimento and the Historic Museum of the Liberation are also worthy options.
To learn about the area's rich and fascinating past, pay a visit to its remaining historical sites. Commence your history tour at Colosseum and the Pantheon. You might also like to get the camera out for some photos at the Spanish Steps and the Arch of Constantine.
Leave time to visit Ponte Milvio or Ponte Sisto, a couple of sturdy yet elegant structures that arc across the waterways of the city. Anyone with an appreciation for civil engineering excellence should also drop by Ponte Sant'Angelo.
When it came to building Palazzo Farnese and Palazzo Venezia, you'll see that money was not an issue. You may also like to meander through the gardens and hear some stories about Palazzo Barberini and Palazzo Chigi.
There is a number of wonderful castles and forts spread throughout the area. Castello di Giulio II, Lunghezza Castle and Castle of Julius II are reminders of a forgotten time.
The spiritual side of the area can be glimpsed at Basilica di Santa Maria Maggiore and Basilica di San Giovanni in Laterano. If you'd like to see a couple more religious sites, keep your eyes peeled for tours at Sistine Chapel and Basilica of St. Paul Outside the Walls.
Before you pack up your suitcase and make your way home, ensure you stop at a few of Rome's other attractions. The Parco di Roma Golf Club and Palazzo della Civilta Italiana are certainly worth a look. If you've got more time to spare, also visit the Vatican Library or the National Central Library of Rome.
Italy's capital is a vibrant and exciting city that is frequented by vacationers from across the globe. Discovering a fantastic place to stay here will be no problem, with 2808 Rome lodgings listed on Expedia's easy-to-use bookings page.
Visitors looking for accommodations at the upper-end of the scale are sure to be delighted, Rome features a number of luxury places, including the Rocco Forte Hotel De Russie, at Via del Babuino 9, and THE FIRST Luxury Art Hotel Roma, at Via del Vantaggio 14. Cheaper lodgings worth considering are the Manfredi Luxury Apartments, at Palazzo Manfredi Via Labicana 125, and the Mood 44, at Vicolo della Torretta, 44.
Located in Esquilino, this hotel is within a 5-minute walk of Colosseum and Basilica di Santa Maria Maggiore. Trevi Fountain and Teatro dell'Opera di Roma are also within 15 minutes. Vittorio Emanuele Station is 7 minutes by foot and Laziali Station is 7 minutes.
Situated near the airport, this hotel is within 16 mi (25 km) of Castelfusano, Hydromania, and Atlantico. PalaLottomatica and Euroma2 are also within 16 mi (25 km).
Situated on the waterfront, this hotel is within 1 mi (2 km) of House of Love and Psyche, Capitolium, and Case a Giardino. Necropoli di Porto Isola Sacra and Grandi Horrea are also within 1 mi (2 km).
This hotel is linked by the skywalk to a moving walkway to all the airport terminals; links to the train station and a free shuttle to the city centre.
Centrally located in Rome, this hotel faces the Teatro dell'Opera and is within 2 blocks of the Repubblica metro station and Via Nazionale and within 1 km (0.5 mi) of Basilica of Santa Maria Maggiore.
Hotel Delle Nazioni is situated in the heart of Rome, just around the corner from the Trevi Fountain. This 4-star hotel is 5 minutes from both the Spanish Steps and stylish Via Condotti shopping.
This family-friendly Fiumicino hotel is located on the waterfront, 2.4 mi (3.9 km) from Necropoli di Porto Isola Sacra, and within 6 mi (10 km) of Parco Leonardo and da Vinci Market Central. Area Archeologica del Porto di Traiano and House of Love and Psyche are also within 6 mi (10 km).
The neoclassical Hotel Majestic is located less than 1 km (0.6 mi) from the Borghese Art Gallery, Villa Borghese gardens, Trevi Fountain, and the Spanish Steps.