The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

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Our top choices for Mayo Clinic Scottsdale hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

louis

￥16,929 total

includes taxes & fees

Nov 22 - Nov 23

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

2. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Jose Jr

￥26,847 total

includes taxes & fees

Nov 16 - Nov 17

A modern infinity pool with a view of mountains and a sunset.

3. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Jessica

￥25,042 total

includes taxes & fees

Dec 10 - Dec 11

A modern dining area with multiple tables and chairs, a fireplace, and a television mounted on the wall.

4. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

LAURA

￥19,619 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

5. Hyatt Place Scottsdale - North

14.1 km from Mayo Clinic Scottsdale

Ted

￥23,499 total

includes taxes & fees

Nov 23 - Nov 24

An outdoor patio with two sofas facing a stone fire pit, under a pergola with string lights.

6. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Claudia

￥23,788 total

includes taxes & fees

Nov 23 - Nov 24

A Courtyard by Marriott hotel with a landscaped entrance featuring a small waterfall and rock formations.

7. Courtyard by Marriott Scottsdale North

13.6 km from Mayo Clinic Scottsdale

wieslaw

￥15,918 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a high ceiling, multiple seating areas, a reception desk, and a television screen.

8. Embassy Suites by Hilton Phoenix Scottsdale

17.8 km from Mayo Clinic Scottsdale

Matthew

￥24,026 total

includes taxes & fees

Nov 22 - Nov 23

A modern hotel with a flat roof, multiple floors, and a sign indicating 'Springhill Suites'.

9. SpringHill Suites Scottsdale North

13.8 km from Mayo Clinic Scottsdale

John

￥15,036 total

includes taxes & fees

Nov 22 - Nov 23

A hotel lobby with a reception desk, seating area, and a large wall mural.

10. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Saad

￥18,363 total

includes taxes & fees

Nov 23 - Nov 24

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

11. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

Ryan

￥17,712 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

12. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

James

￥18,549 total

includes taxes & fees

Nov 23 - Nov 24

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

13. Hyatt House North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Chantella

￥28,093 total

includes taxes & fees

Nov 16 - Nov 17

A swimming pool with a bridge structure, surrounded by buildings with outdoor seating and a clear sky.

14. Holiday Inn & Suites Scottsdale North - Airpark by IHG

9.7 km from Mayo Clinic Scottsdale

Ally Marie

￥20,530 total

includes taxes & fees

Nov 23 - Nov 24

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

15. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.1 km from Mayo Clinic Scottsdale

Irene

￥19,244 total

includes taxes & fees

Nov 30 - Dec 1

An outdoor seating area with fire pit, red Adirondack chairs, and a covered patio with string lights.

16. Home2 Suites by Hilton Scottsdale North

15 km from Mayo Clinic Scottsdale

Susan

￥20,051 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with two beds, a television, a desk with a lamp, and artwork on the wall.

17. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Herbert M Beatty

￥14,645 total

includes taxes & fees

Nov 22 - Nov 23

A hotel with a curved entrance, a flagpole, and palm trees.

18. Holiday Inn Express Scottsdale North by IHG

Central Scottsdale, 12 km from Mayo Clinic Scottsdale

Amy

￥18,189 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor dining area with tables and chairs, a covered seating area, and a mountain backdrop.

19. Mountain Shadows Resort Scottsdale

17 km from Mayo Clinic Scottsdale

karen

￥43,452 total

includes taxes & fees

Nov 23 - Nov 24

An outdoor lounge area with white sofas, a fire pit, and a pool in the background.

20. AC Hotel by Marriott Scottsdale North

Paradise Valley Village, 13.4 km from Mayo Clinic Scottsdale

Stan

￥24,397 total

includes taxes & fees

Nov 24 - Nov 25

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Star rating	Guest rating
Sonesta Select Scottsdale at Mayo Clinic Campus	3.0 star property	8.4 Very good 1,083 reviews	View
Inn at Eagle Mountain	3.5 star property	9.0 Wonderful 1,036 reviews	View
Talking Stick Resort	4.0 star property	9.4 Exceptional 5,192 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	2.5 star property	9.2 Wonderful 2,081 reviews	View
Hyatt Place Scottsdale - North	3.0 star property	9.4 Exceptional 1,299 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

A motel sign with neon lights spelling 'MOTEL' and a green banner with 'Starline Motel' text.

Starlite Motel

Central Mesa

10/10 Excellent

Virginia

Mountain Shadows Resort Scottsdale

Paradise Valley

10/10 Excellent

Rachael

Home2 Suites by Hilton Mesa Longbow, AZ

Falcon Field Area

10/10 Excellent

Alvin

Hyatt House North Scottsdale

Scottsdale

10/10 Excellent

Alicia

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

Courtyard Scottsdale Salt River

Scottsdale

10/10 Excellent

Monica

A modern lounge area with a sectional sofa, armchairs, and a coffee table.

The 233 Suites Unscripted by Hyatt

Downtown

10/10 Excellent

Jade

Canopy by Hilton Scottsdale Old Town

Old Town

10/10 Excellent

Shahar

An outdoor patio area with a central fire feature, seating arrangements, and a covered walkway.

Residence Inn Scottsdale Salt River

Scottsdale

10/10 Excellent

Maria Robelle

Comfort Suites Scottsdale Talking Stick Entertainment District

Scottsdale

10/10 Excellent

Darla

Inn at Eagle Mountain

Eagle Mountain

10/10 Excellent

carla

A modern lounge area with seating, a bar, and a fireplace.

Hotel Valley Ho

Old Town

10/10 Excellent

Andrew T

A pool area with multiple swimming pools, lounge chairs, and potted plants.

Fairfield Inn & Suites by Marriott Tempe

Tempe

10/10 Excellent

I planned a weekend staycation and just wanted a quiet weekend. The price was shockingly great for the location and quality, the reviews and photos sold me and it didn't disappoint. The pool is beautiful. The restaurant in the hotel is pretty good as well, we ordered the Cowboy Burger and the Surf n Turf Burger and both were very good. The hotel was clean, the location is convenient being by Tempe Marketplace so there's plenty to eat and do, and it was overall a great option. I'd absolutely stay...

Krimsun

A hotel pool area with sun loungers, a children's play area, and a building with a sign.

Home2 Suites by Hilton Scottsdale Salt River

Scottsdale

10/10 Excellent

Tracy

A resort with multiple buildings, a large pool area, and surrounding mountains.

ADERO Scottsdale Resort, Autograph Collection

Scottsdale

10/10 Excellent

LaKoya

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

Wekopa Casino Resort

Fort McDowell

10/10 Excellent

Helen

Frequently Asked Questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

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Find hotels near Mayo Clinic Scottsdale, Phoenix from ￥13,297

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Our top choices for Mayo Clinic Scottsdale hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Inn at Eagle Mountain

3. Talking Stick Resort

4. Comfort Suites Scottsdale Talking Stick Entertainment District

5. Hyatt Place Scottsdale - North

6. Home2 Suites by Hilton Mesa Longbow, AZ

7. Courtyard by Marriott Scottsdale North

8. Embassy Suites by Hilton Phoenix Scottsdale

9. SpringHill Suites Scottsdale North

10. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

11. Aiden by Best Western Scottsdale North

12. Sonesta ES Suites Scottsdale Paradise Valley

13. Hyatt House North Scottsdale

14. Holiday Inn & Suites Scottsdale North - Airpark by IHG

15. Best Western Plus Scottsdale Thunderbird Suites

16. Home2 Suites by Hilton Scottsdale North

17. Spark by Hilton Fountain Hills Scottsdale

18. Holiday Inn Express Scottsdale North by IHG

19. Mountain Shadows Resort Scottsdale

20. AC Hotel by Marriott Scottsdale North

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Starlite Motel

10/10 Excellent

Frequently Asked Questions

What's the area like around Mayo Clinic Scottsdale?

What's the best place to stay near Mayo Clinic Scottsdale?

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

What can I see and do near Mayo Clinic Scottsdale?

Explore a world of travel with Expedia