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Our top choices for Mayo Clinic Scottsdale hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

Sonesta Select Scottsdale at Mayo Clinic Campus
3.0 star property
0.3 km from Mayo Clinic Scottsdale
8.4 out of 10, Very good, (1,082 reviews)
"all good happy place to stay"
United States
louis
The price is ￥14,897
￥16,978 total
includes taxes & fees
Nov 22 - Nov 23
Sonesta Select Scottsdale at Mayo Clinic Campus
A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

2. Inn at Eagle Mountain

Inn at Eagle Mountain
3.5 star property
3.1 km from Mayo Clinic Scottsdale
9.0 out of 10, Wonderful, (1,040 reviews)
"Great place to stay, very roomy"
United States
Jose Jr
The price is ￥22,467
￥25,650 total
includes taxes & fees
Dec 10 - Dec 11
Inn at Eagle Mountain
A modern infinity pool with a view of mountains and a sunset.

3. Talking Stick Resort

Talking Stick Resort
4.0 star property
8.8 km from Mayo Clinic Scottsdale
9.4 out of 10, Exceptional, (5,192 reviews)
"I loved staying here!"
United States
Jessica
The price is ￥18,066
￥25,116 total
includes taxes & fees
Dec 10 - Dec 11
Talking Stick Resort
An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

4. Hyatt Place Scottsdale - North

Hyatt Place Scottsdale - North
3.0 star property
14.1 km from Mayo Clinic Scottsdale
9.4 out of 10, Exceptional, (1,298 reviews)
"Clean rooms, friendly staff, good breakfast spread."
United States
Ted
The price is ￥20,682
￥23,570 total
includes taxes & fees
Nov 22 - Nov 23
Hyatt Place Scottsdale - North
A modern dining area with multiple tables and chairs, a fireplace, and a television mounted on the wall.

5. Comfort Suites Scottsdale Talking Stick Entertainment District

Comfort Suites Scottsdale Talking Stick Entertainment District
2.5 star property
9.6 km from Mayo Clinic Scottsdale
9.2 out of 10, Wonderful, (2,077 reviews)
"would definitely stay here again"
United States
LAURA
The price is ￥17,258
￥19,678 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Suites Scottsdale Talking Stick Entertainment District
A modern kitchen with dark cabinetry, a wooden island, and pendant lighting.

6. Close to Hiking! Family-friendly Mesa Retreat

Close to Hiking! Family-friendly Mesa Retreat
3.0 star property
13.6 km from Mayo Clinic Scottsdale
The price is ￥31,379
￥127,348 total
includes taxes & fees
Nov 23 - Nov 24
Close to Hiking! Family-friendly Mesa Retreat
An outdoor patio with two sofas facing a stone fire pit, under a pergola with string lights.

7. Home2 Suites by Hilton Mesa Longbow, AZ

Home2 Suites by Hilton Mesa Longbow, AZ
4.0 star property
14.8 km from Mayo Clinic Scottsdale
9.6 out of 10, Exceptional, (929 reviews)
"Clean room, nice outdoor pool"
Canada
Claudia
The price is ￥21,149
￥24,167 total
includes taxes & fees
Nov 24 - Nov 25
Home2 Suites by Hilton Mesa Longbow, AZ
A hotel room with two beds, a television, a desk with a lamp, and artwork on the wall.

8. Spark by Hilton Fountain Hills Scottsdale

Spark by Hilton Fountain Hills Scottsdale
2.5 star property
7.6 km from Mayo Clinic Scottsdale
8.8 out of 10, Excellent, (341 reviews)
"Excellent value for a traveler."
United States
Herbert M Beatty
The price is ￥12,865
￥14,689 total
includes taxes & fees
Nov 16 - Nov 17
Spark by Hilton Fountain Hills Scottsdale
A spacious living area with a kitchen, modern furniture, and a fireplace.

9. Fountain Park Hotel, BW Signature Collection

Fountain Park Hotel, BW Signature Collection
3.0 star property
7.3 km from Mayo Clinic Scottsdale
9.0 out of 10, Wonderful, (1,003 reviews)
"The location to family was perfect. We used the work out facilities and enjoyed many near by restaurants. We've stayed at this property several times throughout the past 15 years. The price point is perfect for our needs."
United States
Laura
The price is ￥18,859
￥21,533 total
includes taxes & fees
Nov 29 - Nov 30
Fountain Park Hotel, BW Signature Collection
A hotel lobby with a reception desk, seating area, and a large wall mural.

10. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
3.0 star property
Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale
8.8 out of 10, Excellent, (1,908 reviews)
"We had a great stay, Thank you!"
Canada
Saad
The price is ￥16,162
￥18,420 total
includes taxes & fees
Nov 23 - Nov 24
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
A Courtyard by Marriott hotel with a landscaped entrance featuring a small waterfall and rock formations.

11. Courtyard by Marriott Scottsdale North

Courtyard by Marriott Scottsdale North
3.0 star property
13.6 km from Mayo Clinic Scottsdale
8.6 out of 10, Excellent, (1,004 reviews)
"Staff was helpful"
United States
Katie
The price is ￥14,121
￥15,966 total
includes taxes & fees
Nov 22 - Nov 23
Courtyard by Marriott Scottsdale North
A modern hotel with a flat roof, multiple floors, and a sign indicating 'Springhill Suites'.

12. SpringHill Suites Scottsdale North

SpringHill Suites Scottsdale North
3.0 star property
13.8 km from Mayo Clinic Scottsdale
8.8 out of 10, Excellent, (1,000 reviews)
"All as expected.....GREAT staff and breakfasts"
United States
John
The price is ￥13,336
￥15,079 total
includes taxes & fees
Nov 22 - Nov 23
SpringHill Suites Scottsdale North
A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

13. Aiden by Best Western Scottsdale North

Aiden by Best Western Scottsdale North
3.0 star property
8.7 km from Mayo Clinic Scottsdale
9.0 out of 10, Wonderful, (1,218 reviews)
"Nice hotel in nice area. Very clean property. Room was nice and comfortable."
United States
Ryan
The price is ￥15,587
￥17,765 total
includes taxes & fees
Nov 22 - Nov 23
Aiden by Best Western Scottsdale North
An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

14. Wekopa Casino Resort

Wekopa Casino Resort
4.0 star property
10.3 km from Mayo Clinic Scottsdale
9.2 out of 10, Wonderful, (1,013 reviews)
"Great stay"
United States
Joshua
The price is ￥18,618
￥25,963 total
includes taxes & fees
Nov 25 - Nov 26
Wekopa Casino Resort
A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

15. Hyatt House North Scottsdale

Hyatt House North Scottsdale
3.5 star property
14.1 km from Mayo Clinic Scottsdale
9.6 out of 10, Exceptional, (1,021 reviews)
"Awesome staff and great area"
United States
Chantella
The price is ￥21,395
￥24,382 total
includes taxes & fees
Nov 18 - Nov 19
Hyatt House North Scottsdale
A swimming pool with a bridge structure, surrounded by buildings with outdoor seating and a clear sky.

16. Holiday Inn & Suites Scottsdale North - Airpark by IHG

Holiday Inn & Suites Scottsdale North - Airpark by IHG
3.5 star property
9.7 km from Mayo Clinic Scottsdale
9.0 out of 10, Wonderful, (936 reviews)
"Clean room and helpful staff. Definitely would stay again"
United States
Ally Marie
The price is ￥18,701
￥21,313 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn & Suites Scottsdale North - Airpark by IHG
An outdoor seating area with fire pit, red Adirondack chairs, and a covered patio with string lights.

17. Home2 Suites by Hilton Scottsdale North

Home2 Suites by Hilton Scottsdale North
3.0 star property
15 km from Mayo Clinic Scottsdale
9.0 out of 10, Wonderful, (835 reviews)
"Very nice place conveniently located. Plenty of parking great staff"
United States
Susan
The price is ￥18,590
￥21,187 total
includes taxes & fees
Nov 29 - Nov 30
Home2 Suites by Hilton Scottsdale North
A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

18. Sonesta ES Suites Scottsdale Paradise Valley

Sonesta ES Suites Scottsdale Paradise Valley
3.0 star property
14 km from Mayo Clinic Scottsdale
9.2 out of 10, Wonderful, (1,007 reviews)
"Friendly staff, good breakfast, dated rooms, clean"
United States
James
The price is ￥17,591
￥20,048 total
includes taxes & fees
Nov 22 - Nov 23
Sonesta ES Suites Scottsdale Paradise Valley
A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

19. Best Western Plus Scottsdale Thunderbird Suites

Best Western Plus Scottsdale Thunderbird Suites
3.0 star property
Thunderbird Industrial Airpark, 12.1 km from Mayo Clinic Scottsdale
8.8 out of 10, Excellent, (1,005 reviews)
"All around a great place to stay for the price, thanks again."
United States
Irene
The price is ￥16,935
￥19,302 total
includes taxes & fees
Nov 30 - Dec 1
Best Western Plus Scottsdale Thunderbird Suites
A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

20. Courtyard Scottsdale Salt River

Courtyard Scottsdale Salt River
3.5 star property
12.2 km from Mayo Clinic Scottsdale
9.4 out of 10, Exceptional, (1,001 reviews)
"Very nice stay the staff are super friendly and helpful"
United States
Karl
The price is ￥20,072
￥22,876 total
includes taxes & fees
Nov 29 - Nov 30
Courtyard Scottsdale Salt River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.
Sonesta Select Scottsdale at Mayo Clinic Campus
3.0 star property
8.4
Very good
1,082 reviews
View
A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.
Inn at Eagle Mountain
3.5 star property
9.0
Wonderful
1,040 reviews
View
A modern infinity pool with a view of mountains and a sunset.
Talking Stick Resort
4.0 star property
9.4
Exceptional
5,192 reviews
View
An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.
Hyatt Place Scottsdale - North
3.0 star property
9.4
Exceptional
1,298 reviews
View
A modern dining area with multiple tables and chairs, a fireplace, and a television mounted on the wall.
Comfort Suites Scottsdale Talking Stick Entertainment District
2.5 star property
9.2
Wonderful
2,077 reviews
View

Top Mayo Clinic Scottsdale Hotel Reviews

A motel sign with neon lights spelling 'MOTEL' and a green banner with 'Starline Motel' text.
Starlite Motel

Starlite Motel

Starlite Motel
Central Mesa

10/10 Excellent

Very comfortable and it had everything I needed to make breakfast and get a good night rest.
United States
Virginia
Reviewed October 1, 2026
Starlite Motel

Frequently Asked Questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

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