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Our top choices for Mayo Clinic hotels

Sonesta Select Scottsdale at Mayo Clinic Campus

Sonesta Select Scottsdale at Mayo Clinic Campus
3.0 star property
Mayo Clinic
8.2 out of 10, Very Good, (1,067 reviews)
"Very clean, comfortable room. Quiet area and easy access to main road. Very comfortable bed. Would stay again."
United States
Efrain
The price is ¥15,738
¥17,937 total
includes taxes & fees
Apr 12 - Apr 13
Sonesta Select Scottsdale at Mayo Clinic Campus

Surestay by Best Western Phoenix Airport near Downtown

Surestay by Best Western Phoenix Airport near Downtown
2.5 star property
25.5 km from Mayo Clinic
8.4 out of 10, Very Good, (1,860 reviews)
"Clean rooms, close to the airport."
United States
Sharon
The price is ¥24,163
¥27,321 total
includes taxes & fees
Mar 23 - Mar 24
Surestay by Best Western Phoenix Airport near Downtown

Drury Inn & Suites Phoenix Airport

Drury Inn & Suites Phoenix Airport
3.0 star property
27.7 km from Mayo Clinic
9.6 out of 10, Exceptional, (2,394 reviews)
"Friendly staff, clean room and nice amenities. Very convenient location."
United States
William
The price is ¥22,413
¥25,342 total
includes taxes & fees
Apr 13 - Apr 14
Drury Inn & Suites Phoenix Airport

Best Western Apache Junction Inn

Best Western Apache Junction Inn
2.5 star property
28.9 km from Mayo Clinic
8.8 out of 10, Excellent, (682 reviews)
"All staff was excellent, property clean"
United States
Brian
The price is ¥25,434
¥28,359 total
includes taxes & fees
Mar 30 - Mar 31
Best Western Apache Junction Inn

My Place Hotel-Phoenix East Mesa AZ

My Place Hotel-Phoenix East Mesa AZ
2.0 star property
28.2 km from Mayo Clinic
8.8 out of 10, Excellent, (109 reviews)
"Very clean room, comfy beds, nice and quiet location. "
United States
Courtney
The price is ¥16,680
¥19,060 total
includes taxes & fees
Apr 1 - Apr 2
My Place Hotel-Phoenix East Mesa AZ

Hilton Garden Inn Phoenix Airport North

Hilton Garden Inn Phoenix Airport North
3.0 star property
24.2 km from Mayo Clinic
8.8 out of 10, Excellent, (2,602 reviews)
"Close to airport and helpful staff"
United States
Michael
The price is ¥22,030
¥24,910 total
includes taxes & fees
Apr 12 - Apr 13
Hilton Garden Inn Phoenix Airport North

Fountain Park Hotel, BW Signature Collection

Fountain Park Hotel, BW Signature Collection
3.0 star property
7.2 km from Mayo Clinic
8.8 out of 10, Excellent, (1,000 reviews)
"Great place to stay. Close to everything!"
United States
Alesia
The price is ¥17,431
¥19,901 total
includes taxes & fees
Apr 12 - Apr 13
Fountain Park Hotel, BW Signature Collection

Wekopa Casino Resort

Wekopa Casino Resort
4.0 star property
10.1 km from Mayo Clinic
9.2 out of 10, Wonderful, (1,002 reviews)
"Amazing hotel and staff!!"
United States
bryan
Wekopa Casino Resort

Hyatt Place Tempe Phoenix Airport

Hyatt Place Tempe Phoenix Airport
3.0 star property
23.5 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,083 reviews)
"Great location, the room was clean and comfortable. "
United States
DAVID
The price is ¥24,163
¥27,563 total
includes taxes & fees
Apr 6 - Apr 7
Hyatt Place Tempe Phoenix Airport

Stay7 Studios Hotel Phoenix

Stay7 Studios Hotel Phoenix
2.0 star property
29.8 km from Mayo Clinic
6.8 out of 10, (454 reviews)
"The staff was extremely friendly and helpful."
United States
Stephanie
The price is ¥17,010
¥19,232 total
includes taxes & fees
Apr 7 - Apr 8
Stay7 Studios Hotel Phoenix

Talking Stick Resort

Talking Stick Resort
4.0 star property
9 km from Mayo Clinic
9.2 out of 10, Wonderful, (4,507 reviews)
"Very nice stay"
Canada
Kelvin
The price is ¥27,040
¥35,363 total
includes taxes & fees
Apr 12 - Apr 13
Talking Stick Resort

Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG
2.5 star property
20.2 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,010 reviews)
"Clean conveniently located near shopping restaurants"
United States
Marc
The price is ¥22,733
¥25,704 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

Sentral Sol Modern

Sentral Sol Modern
4.0 star property
29.9 km from Mayo Clinic
9.4 out of 10, Exceptional, (277 reviews)
"Great place to stay. I would stay again."
United States
Andrew
The price is ¥22,748
¥30,214 total
includes taxes & fees
Apr 6 - Apr 7
Sentral Sol Modern

Home2 Suites by Hilton Phoenix Downtown

Home2 Suites by Hilton Phoenix Downtown
3.0 star property
30.3 km from Mayo Clinic
9.2 out of 10, Wonderful, (1,286 reviews)
"Great location."
United States
Melissa
The price is ¥29,592
¥33,460 total
includes taxes & fees
Apr 13 - Apr 14
Home2 Suites by Hilton Phoenix Downtown

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
3.0 star property
Central Scottsdale, 9 km from Mayo Clinic
8.8 out of 10, Excellent, (1,879 reviews)
"The staff were so friendly and helpful. "
United States
Sharron
The price is ¥14,166
¥16,145 total
includes taxes & fees
Apr 5 - Apr 6
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Hilton Phoenix Airport

Hilton Phoenix Airport
4.0 star property
25 km from Mayo Clinic
8.8 out of 10, Excellent, (1,099 reviews)
"Staff was incredibly helpful and accomodating."
United States
Brittany
The price is ¥22,965
¥25,966 total
includes taxes & fees
Apr 12 - Apr 13
Hilton Phoenix Airport

Tempe Oasis

Tempe Oasis
2.0 star property
19.7 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,125 reviews)
"Very nice place to stay!"
United States
Isabelle
The price is ¥19,778
¥24,343 total
includes taxes & fees
Apr 7 - Apr 8
Tempe Oasis

Marriott Phoenix Airport

Marriott Phoenix Airport
3.5 star property
22.7 km from Mayo Clinic
9.2 out of 10, Wonderful, (1,000 reviews)
"Staff was courteous and beds were super comfy."
United States
Nancy
The price is ¥31,333
¥35,428 total
includes taxes & fees
Apr 10 - Apr 11
Marriott Phoenix Airport

Hyatt Place Phoenix/Mesa

Hyatt Place Phoenix/Mesa
3.0 star property
17.9 km from Mayo Clinic
9.2 out of 10, Wonderful, (1,773 reviews)
"This hotel was clean with a friendly staff and conveniently located near many restaurants and Cubs spring training."
United States
Gretchen
The price is ¥18,758
¥21,435 total
includes taxes & fees
Apr 12 - Apr 13
Hyatt Place Phoenix/Mesa

Red Roof Inn PLUS+ Tempe - Phoenix Airport

Red Roof Inn PLUS+ Tempe - Phoenix Airport
2.5 star property
25.5 km from Mayo Clinic
7.4 out of 10, Good, (1,000 reviews)
"Clean room, friendly staff easy access definitely will stay here again"
United States
kenneth
The price is ¥14,949
¥17,053 total
includes taxes & fees
Mar 29 - Mar 30
Red Roof Inn PLUS+ Tempe - Phoenix Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most.

Downtown Phoenix

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

Rio Verde Foothills

If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Tom's Thumb Trail and Tonto Verde Golf Club.

Old Town

Old Town is known for its popular shops, and you can see some sights in the area like Scottsdale Waterfront and Western Spirit: Scottsdale's Museum of the West.

Camelback East

Adjacent to Paradise Valley and Scottsdale, Camelback East Village boasts two main cores and sits between Piestewa Peak and Camelback Mountain. Explore the vibrant 24th Street and Camelback Road or 44th Street and Van Buren Street areas.

North Phoenix

While you're in North Phoenix, take in top sights like Reach 11 Sports Complex and jump on the metro at 19th Avenue/ Dunlap Station to see more of the city.

Top Mayo Clinic Hotel Reviews

Frequently asked questions

What is Mayo Clinic like?
Travelers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighborhood.
Where is the best place to stay in Mayo Clinic?
Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.
How many hotels will I be able to find in the Mayo Clinic area?
With 14 Expedia hotels and other accommodations in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.
If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?
Yes! Most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in Mayo Clinic.
Where can I learn more about changing or cancelling my trip to Mayo Clinic?
For more information about updating your trip to Mayo Clinic or cancelling it, go to https://www.expedia.com/service/.
What is there to do around this Scottsdale neighborhood?
A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain, and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.

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