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Discover 12,884 Mayo Clinic hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Sonesta Select Scottsdale at Mayo Clinic Campus
Lobby lounge

Sonesta Select Scottsdale at Mayo Clinic Campus

3.0 star property
8.2 out of 10, Very Good, (1005)
"Stayed there before "
The price is ￥13,113
￥14,946 total
includes taxes & fees
Sep 11 - Sep 12
Sonesta Select Scottsdale at Mayo Clinic Campus
La Quinta Inn & Suites by Wyndham Mesa Superstition Springs
Gazebo

La Quinta Inn & Suites by Wyndham Mesa Superstition Springs

3.0 star property
8.2 out of 10, Very Good, (1708)
"Great spot to stay"
The price is ￥10,349
￥11,826 total
includes taxes & fees
Sep 14 - Sep 15
La Quinta Inn & Suites by Wyndham Mesa Superstition Springs
Westgate Painted Mountain Golf Resort
Property grounds

Westgate Painted Mountain Golf Resort

4.0 star property
8.4 out of 10, Very Good, (1001)
"Wonderful place to stay"
The price is ￥11,885
￥13,580 total
includes taxes & fees
Sep 14 - Sep 15
Westgate Painted Mountain Golf Resort
Best Western North Phoenix Hotel
Property amenity

Best Western North Phoenix Hotel

2.5 star property
8.8 out of 10, Excellent, (1003)
"Conveniently located to numerous shopping centers and eateries. "
The price is ￥12,399
￥14,020 total
includes taxes & fees
Sep 17 - Sep 18
Best Western North Phoenix Hotel
Days Inn & Suites by Wyndham Mesa Near Phoenix
Room, 2 Queen Beds, Accessible, Non Smoking | Pillowtop beds, in-room safe, desk, iron/ironing board

Days Inn & Suites by Wyndham Mesa Near Phoenix

3.0 star property
9.0 out of 10, Wonderful, (1800)
"Good place to stay"
The price is ￥9,194
￥10,506 total
includes taxes & fees
Sep 17 - Sep 18
Days Inn & Suites by Wyndham Mesa Near Phoenix
Hilton Phoenix Tapatio Cliffs Resort
Exterior

Hilton Phoenix Tapatio Cliffs Resort

4.0 star property
8.4 out of 10, Very Good, (2100)
"Good place to take family, nice views, great pools"
The price is ￥19,319
￥28,313 total
includes taxes & fees
Sep 17 - Sep 18
Hilton Phoenix Tapatio Cliffs Resort
SureStay Plus by Best Western Mesa Superstition Springs
Exterior

SureStay Plus by Best Western Mesa Superstition Springs

2.5 star property
8.4 out of 10, Very Good, (1558)
"Quiet place to stay "
The price is ￥10,909
￥12,466 total
includes taxes & fees
Sep 11 - Sep 12
SureStay Plus by Best Western Mesa Superstition Springs
FOUNDRE Phoenix
Balcony

FOUNDRE Phoenix

4.0 star property
9.2 out of 10, Wonderful, (2027)
"Loved this stay!"
The price is ￥19,209
￥25,723 total
includes taxes & fees
Sep 22 - Sep 23
FOUNDRE Phoenix
The Azure Hotel
Reception

The Azure Hotel

2.5 star property
8.8 out of 10, Excellent, (1510)
"Nice and clean local hotel, very well priced and close to downtown mesa. Will be my go to stay when visiting family in Mesa. "
The Azure Hotel
Wekopa Casino Resort
Terrace/patio

Wekopa Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1000)
"Overall staff are helpful and friendly in the pool area & restaurants."
Wekopa Casino Resort
Hyatt Regency Phoenix
2 restaurants, breakfast, lunch, dinner served; American cuisine

Hyatt Regency Phoenix

4.0 star property
9.0 out of 10, Wonderful, (1815)
"I love this hotel clean, comfortable "
The price is ￥24,936
￥32,362 total
includes taxes & fees
Sep 12 - Sep 13
Hyatt Regency Phoenix
Sentral Sol Modern
Lobby sitting area

Sentral Sol Modern

2.0 star property
The price is ￥19,783
￥26,055 total
includes taxes & fees
Oct 1 - Oct 2
Sentral Sol Modern
Country Inn & Suites by Radisson, Mesa, AZ
Lobby

Country Inn & Suites by Radisson, Mesa, AZ

2.5 star property
7.8 out of 10, Good, (1001)
"Very professional staff and close to good restaurants."
The price is ￥10,520
￥12,021 total
includes taxes & fees
Sep 17 - Sep 18
Country Inn & Suites by Radisson, Mesa, AZ
Kimpton Hotel Palomar Phoenix Cityscape by IHG
Exterior

Kimpton Hotel Palomar Phoenix Cityscape by IHG

4.0 star property
9.0 out of 10, Wonderful, (1137)
"Beds were super comfy and the bar and staff were great!"
The price is ￥24,914
￥34,004 total
includes taxes & fees
Sep 13 - Sep 14
Kimpton Hotel Palomar Phoenix Cityscape by IHG
Arizona Grand Resort & Spa
Water park

Arizona Grand Resort & Spa

4.0 star property
8.6 out of 10, Excellent, (2170)
"We always like staying here!!Great Family Resort"
The price is ￥14,595
￥29,839 total
includes taxes & fees
Sep 18 - Sep 19
Arizona Grand Resort & Spa
Country Inn & Suites by Radisson, Phoenix Airport, AZ
Exterior

Country Inn & Suites by Radisson, Phoenix Airport, AZ

3.0 star property
8.2 out of 10, Very Good, (2677)
"Excellent hotel"
The price is ￥11,940
￥13,500 total
includes taxes & fees
Sep 21 - Sep 22
Country Inn & Suites by Radisson, Phoenix Airport, AZ
Hyatt Place Phoenix -North
Exterior

Hyatt Place Phoenix -North

3.0 star property
7.0 out of 10, Good, (1001)
"Overall the stay was good the staff that weekend was amazing all very attentive and happy. I’ve stayed before this time was better. Started off bad had to change rooms twice before I got a room to stay in for the weekend. The room did have a weird smell but we felt with it. "
The price is ￥14,587
￥16,494 total
includes taxes & fees
Sep 17 - Sep 18
Hyatt Place Phoenix -North
Hotel Valley Ho
Breakfast, lunch and dinner served

Hotel Valley Ho

4.5 star property
9.6 out of 10, Exceptional, (1925)
"Great location to bars and shops."
The price is ￥30,839
￥35,147 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Valley Ho
Hilton Phoenix Resort at the Peak
7 outdoor pools, pool umbrellas, sun loungers

Hilton Phoenix Resort at the Peak

4.0 star property
7.6 out of 10, Good, (3176)
"Great stay, staff super friendly and helpful."
The price is ￥21,165
￥29,736 total
includes taxes & fees
Sep 29 - Sep 30
Hilton Phoenix Resort at the Peak
La Quinta Inn & Suites by Wyndham Phoenix Mesa West
Exterior

La Quinta Inn & Suites by Wyndham Phoenix Mesa West

3.0 star property
7.6 out of 10, Good, (1390)
"Very good location, cleanliness and friendly staff. "
The price is ￥9,518
￥10,876 total
includes taxes & fees
Oct 6 - Oct 7
La Quinta Inn & Suites by Wyndham Phoenix Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most.
Downtown Phoenix which includes signage and night scenes

Downtown Phoenix

3 out of top 10 points of interest in this area

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

Old Town

Old Town

Old Town is known for its popular shops, and you can see some sights in the area like Scottsdale Waterfront and Western Spirit: Scottsdale's Museum of the West.

Papago Park featuring desert views as well as a small group of people

Camelback East

2 out of top 10 points of interest in this area

Adjacent to Paradise Valley and Scottsdale, Camelback East Village boasts two main cores and sits between Piestewa Peak and Camelback Mountain. Explore the vibrant 24th Street and Camelback Road or 44th Street and Van Buren Street areas.

Central Scottsdale

1 out of top 10 points of interest in this area

While visiting Central Scottsdale, you might make a stop by sights like Scottsdale Ranch Park and Starfire Golf Club at Scottsdale Country Club.

East Mesa

While you're in East Mesa, take in top sights like Salt River Tubing and jump on the metro at Superstition Springs Transit Center to see more of the city.

Top Mayo Clinic Hotel Reviews

Talking Stick Resort

Talking Stick Resort

10/10 Excellent
"Property was really nice and clean everyone was helpful and nice. You can use your reward card at different restaurants inside of hotel. Only issue is if you dont rent a car you have to uber everywhere you go nothing is in walking distance of property "
Brandy 3-night trip
Posted 2 days ago
Talking Stick Resort

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is Mayo Clinic like?

Travelers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighborhood.

Where is the best place to stay in Mayo Clinic?

Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.

How many hotels will I be able to find in the Mayo Clinic area?

With 14 Expedia hotels and other accommodations in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.

If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?

Yes! Most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in Mayo Clinic.

Where can I learn more about changing or cancelling my trip to Mayo Clinic?

For more information about updating your trip to Mayo Clinic or cancelling it, go to https://www.expedia.com/service/.

What is there to do around this Scottsdale neighborhood?

A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain, and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.