Top Mayo Clinic Hotels from ￥14,263

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Our top choices for Mayo Clinic hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

Mayo Clinic

louis

￥16,978 total

includes taxes & fees

Nov 22 - Nov 23

A modern dining area with multiple tables and chairs, a fireplace, and a television mounted on the wall.

2. Comfort Suites Scottsdale Talking Stick Entertainment District

9.7 km from Mayo Clinic

LAURA

￥19,678 total

includes taxes & fees

Nov 22 - Nov 23

A hotel lobby with a reception desk, seating area, and a large wall mural.

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 9 km from Mayo Clinic

Saad

￥18,424 total

includes taxes & fees

Nov 23 - Nov 24

A hotel lobby with a reception desk, seating area, and a television screen.

4. Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

20.2 km from Mayo Clinic

Jacque

￥19,712 total

includes taxes & fees

Nov 23 - Nov 24

A modern infinity pool with a view of mountains and a sunset.

5. Talking Stick Resort

9 km from Mayo Clinic

Jessica

￥25,697 total

includes taxes & fees

Dec 10 - Dec 11

A restaurant setting with round tables, chairs, and empty wine glasses.

6. Aiden by Best Western Scottsdale North

8.8 km from Mayo Clinic

Ryan

￥17,765 total

includes taxes & fees

Nov 22 - Nov 23

A water park with a multi-level water slide, palm trees, and a pool area with lounge chairs.

7. Holiday Inn Club Vacations Scottsdale Resort by IHG

13.3 km from Mayo Clinic

Christine

￥41,362 total

includes taxes & fees

Nov 30 - Dec 1

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

8. Hyatt Place Scottsdale - North

14.2 km from Mayo Clinic

Ted

￥23,570 total

includes taxes & fees

Nov 22 - Nov 23

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

9. Inn at Eagle Mountain

3 km from Mayo Clinic

Jose Jr

￥25,650 total

includes taxes & fees

Dec 10 - Dec 11

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

10. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.3 km from Mayo Clinic

Irene

￥19,302 total

includes taxes & fees

Nov 30 - Dec 1

A Courtyard by Marriott hotel with a landscaped entrance featuring a small waterfall and rock formations.

11. Courtyard by Marriott Scottsdale North

13.7 km from Mayo Clinic

Katie

￥19,648 total

includes taxes & fees

Nov 22 - Nov 23

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

12. Hyatt House North Scottsdale

14.2 km from Mayo Clinic

Chantella

￥24,382 total

includes taxes & fees

Nov 15 - Nov 16

A spacious living area with a kitchen, modern furniture, and a fireplace.

13. Fountain Park Hotel, BW Signature Collection

7.2 km from Mayo Clinic

Laura

￥21,533 total

includes taxes & fees

Nov 29 - Nov 30

A modern breakfast area with a sign reading "EXPRESS START BREAKFAST" and a "GOOD MORNING" sign on the wall.

14. Holiday Inn Express & Suites Phoenix - Airport North by IHG

23.2 km from Mayo Clinic

XIN

￥17,560 total

includes taxes & fees

Nov 24 - Nov 25

A modern lobby with a sofa, a coffee table, and a seating area with chairs.

15. Holiday Inn Hotel & Suites PHOENIX AIRPORT by IHG

25.4 km from Mayo Clinic

Bree

￥15,770 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor dining area with wicker furniture and candles, overlooking a well-maintained garden and buildings.

16. Sonesta Suites Scottsdale Gainey Ranch

12.4 km from Mayo Clinic

Hilda

￥33,237 total

includes taxes & fees

Nov 25 - Nov 26

A spacious lobby with a reception desk, seating area, and a staircase.

17. Hilton Phoenix Airport

25 km from Mayo Clinic

Ilene

￥18,124 total

includes taxes & fees

Nov 22 - Nov 23

A modern hotel room with a grey sofa, a round table, a bed with white linens, a large abstract painting, a floor lamp, and a window with curtains.

18. Hyatt Place Tempe Phoenix Airport

23.5 km from Mayo Clinic

dularie

￥18,258 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a fireplace, seating areas, and large windows.

19. Hilton Garden Inn Phoenix Airport North

24.2 km from Mayo Clinic

Aaliyah

￥16,601 total

includes taxes & fees

Nov 22 - Nov 23

A swimming pool with people on inflatable floats, lounge chairs, and umbrellas in the background.

20. Wekopa Casino Resort

10.1 km from Mayo Clinic

Joshua

￥25,963 total

includes taxes & fees

Nov 25 - Nov 26

View all properties

Compare popular hotels in Mayo Clinic

Property	Star rating	Guest rating
Sonesta Select Scottsdale at Mayo Clinic Campus	3.0 star property	8.4 Very good 1,082 reviews	View
Inn at Eagle Mountain	3.5 star property	9.0 Wonderful 1,039 reviews	View
Talking Stick Resort	4.0 star property	9.4 Exceptional 5,191 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	2.5 star property	9.2 Wonderful 2,077 reviews	View
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale	3.0 star property	8.8 Excellent 1,908 reviews	View

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most.

A cityscape with prominent buildings including a Chase bank and The Arizona Republic building.

Downtown Phoenix

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

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A fountain with three horses, surrounded by red flowers and storefronts.

Old Town

Old Town is known for its popular shops, and you can see some sights in the area like Scottsdale Waterfront and Western Spirit: Scottsdale's Museum of the West.

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A hiker on a rocky trail with mountains in the background.

Rio Verde Foothills

If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Golf Club Scottsdale and Tom's Thumb Trail.

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A rocky hill with palm trees and a body of water.

Camelback East

Adjacent to Paradise Valley and Scottsdale, Camelback East Village boasts two main cores and sits between Piestewa Peak and Camelback Mountain. Explore the vibrant 24th Street and Camelback Road or 44th Street and Van Buren Street areas.

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A mountainous landscape with a city in the valley below.

North Phoenix

While you're in North Phoenix, take in top sights like Reach 11 Sports Complex and jump on the metro at 19th Avenue/ Dunlap Station to see more of the city.

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Top Mayo Clinic Hotel Reviews

Sonesta Select Scottsdale at Mayo Clinic Campus

Central Scottsdale

10/10 Excellent

James

Inn at Eagle Mountain

Eagle Mountain

10/10 Excellent

carla

Comfort Suites Scottsdale Talking Stick Entertainment District

Scottsdale

10/10 Excellent

Darla

Aiden by Best Western Scottsdale North

Central Scottsdale

10/10 Excellent

Ryan

Hyatt House North Scottsdale

Scottsdale

10/10 Excellent

Alicia

A modern lounge area with a sectional sofa, armchairs, and a coffee table.

The 233 Suites Unscripted by Hyatt

Downtown

10/10 Excellent

Jade

Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark

10/10 Excellent

This property is very well managed. We were there 5 nights and gave it a top rating because the rooms were spacious with a sitting area, it's clean, the breakfast and breakfast service was excellent, the pool and grounds were well maintained, and the workout facility was adequate. The front desk was staffed 24/7 It's not a new facility and the furnishings are dated, but everything worked. For North Scottsdale is a good value and we'll be returning there again on our next trip.

J

Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

North Phoenix

10/10 Excellent

Craig

Wekopa Casino Resort

Fort McDowell

10/10 Excellent

Helen

An outdoor seating area with a fire pit, surrounded by chairs and tables, under string lights.

Hilton Vacation Club Scottsdale Links Resort

Scottsdale Links

10/10 Excellent

peter

A modern hotel with a brick facade, large windows, and a covered entrance area.

Springhill Suites Phoenix Scottsdale Marriott

Scottsdale

10/10 Excellent

Anna

A swimming pool with lounge chairs and a covered seating area, surrounded by palm trees and a building with multiple windows.

Hyatt Place Phoenix/Mesa

Riverview

10/10 Excellent

Gina

A modern dining area with tables and chairs, large windows, and a flat-screen TV on the wall.

Best Western Plus Gilbert/Mesa

US 60 Corridor

10/10 Excellent

Keith

Sonesta Suites Scottsdale Gainey Ranch

Scottsdale

10/10 Excellent

My family and I stayed here for 5 nights and it was the best hotel we ever stayed at! We checked in early and was upgraded to a 2 bedroom King suite and then when we needed our sheets changed due to my husband being sick, they went above and beyond...Note...there policy is that they do not change bed sheets and do a full service room clean until the 4th day of stay. Silly policy but they helped us out by doing it when we really needed it! We left the property on day 6 but needed to re-book the...

Jason

A group of people dining at an outdoor table with a view of a pool and palm trees.

Mountain Shadows Resort Scottsdale

Paradise Valley

10/10 Excellent

Rachael

Frequently Asked Questions

What is Mayo Clinic like?

Travelers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighborhood.

Where is the best place to stay in Mayo Clinic?

Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.

How many hotels will I be able to find in the Mayo Clinic area?

With 14 Expedia hotels and other accommodations in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.

If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?

Yes! Most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in Mayo Clinic.

Where can I learn more about changing or cancelling my trip to Mayo Clinic?

For more information about updating your trip to Mayo Clinic or cancelling it, go to https://www.expedia.com/service/.

What is there to do around this Scottsdale neighborhood?

A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain, and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.

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Find hotels in Mayo Clinic, Phoenix from ￥14,263

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Mayo Clinic hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Comfort Suites Scottsdale Talking Stick Entertainment District

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

4. Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

5. Talking Stick Resort

6. Aiden by Best Western Scottsdale North

7. Holiday Inn Club Vacations Scottsdale Resort by IHG

8. Hyatt Place Scottsdale - North

9. Inn at Eagle Mountain

10. Best Western Plus Scottsdale Thunderbird Suites

11. Courtyard by Marriott Scottsdale North

12. Hyatt House North Scottsdale

13. Fountain Park Hotel, BW Signature Collection

14. Holiday Inn Express & Suites Phoenix - Airport North by IHG

15. Holiday Inn Hotel & Suites PHOENIX AIRPORT by IHG

16. Sonesta Suites Scottsdale Gainey Ranch

17. Hilton Phoenix Airport

18. Hyatt Place Tempe Phoenix Airport

19. Hilton Garden Inn Phoenix Airport North

20. Wekopa Casino Resort

Compare popular hotels in Mayo Clinic

Where to stay in Mayo Clinic

Downtown Phoenix

Old Town

Rio Verde Foothills

Camelback East

North Phoenix

Top Mayo Clinic Hotel Reviews

Sonesta Select Scottsdale at Mayo Clinic Campus

10/10 Excellent

Frequently Asked Questions

What is Mayo Clinic like?

Where is the best place to stay in Mayo Clinic?

How many hotels will I be able to find in the Mayo Clinic area?

If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Mayo Clinic?

What is there to do around this Scottsdale neighborhood?

Explore a world of travel with Expedia