Top Mayo Clinic Hotels from ￥13,753

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Our top choices for Mayo Clinic hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

Mayo Clinic

louis

￥18,930 total

includes taxes & fees

Nov 22 - Nov 23

A modern lobby with a stone fireplace, comfortable seating, and a television.

2. Comfort Suites Scottsdale Talking Stick Entertainment District

9.7 km from Mayo Clinic

LAURA

￥19,034 total

includes taxes & fees

Nov 29 - Nov 30

A modern infinity pool with a view of mountains and a sunset.

3. Talking Stick Resort

9 km from Mayo Clinic

Nabeel

￥23,138 total

includes taxes & fees

Dec 15 - Dec 16

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 9 km from Mayo Clinic

Saad

￥17,858 total

includes taxes & fees

Dec 15 - Dec 16

A room with a view of a mountainous landscape through a window.

5. Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

20.2 km from Mayo Clinic

Jacque

￥20,587 total

includes taxes & fees

Nov 22 - Nov 23

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

6. Aiden by Best Western Scottsdale North

8.8 km from Mayo Clinic

Ryan

￥15,674 total

includes taxes & fees

Dec 15 - Dec 16

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

7. Hyatt Place Scottsdale - North

14.2 km from Mayo Clinic

Ted

￥22,798 total

includes taxes & fees

Dec 14 - Dec 15

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

8. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.3 km from Mayo Clinic

Irene

￥17,770 total

includes taxes & fees

Dec 15 - Dec 16

A golf course with a pond, a clubhouse, and a hilly backdrop.

9. Inn at Eagle Mountain

3 km from Mayo Clinic

A Candy

￥27,146 total

includes taxes & fees

Nov 30 - Dec 1

A Courtyard by Marriott hotel with a landscaped entrance featuring a small waterfall and rock formations.

10. Courtyard by Marriott Scottsdale North

13.7 km from Mayo Clinic

Matt

￥16,091 total

includes taxes & fees

Nov 22 - Nov 23

A hotel conference room with multiple tables, chairs, and a kitchenette area.

11. Hilton Phoenix Airport

25 km from Mayo Clinic

Ilene

￥18,266 total

includes taxes & fees

Dec 11 - Dec 12

A hotel room with a large bed, a ceiling fan, a TV, and a view of palm trees through the window.

12. Holiday Inn Club Vacations Scottsdale Resort by IHG

13.3 km from Mayo Clinic

Andrew

￥35,652 total

includes taxes & fees

Nov 17 - Nov 18

An outdoor dining area with wicker furniture and candles, overlooking a well-maintained garden and buildings.

13. Sonesta Suites Scottsdale Gainey Ranch

12.4 km from Mayo Clinic

Collin

￥30,765 total

includes taxes & fees

Dec 14 - Dec 15

A Holiday Inn hotel with a modern facade, a covered entrance, and a parking lot with several cars.

14. Holiday Inn Hotel & Suites PHOENIX AIRPORT by IHG

25.4 km from Mayo Clinic

Bree

￥15,890 total

includes taxes & fees

Nov 23 - Nov 24

A spacious, modern lounge area with multiple seating arrangements, including tables and chairs, and a large window providing a view of the outdoors.

15. Holiday Inn Express & Suites Phoenix - Airport North by IHG

23.2 km from Mayo Clinic

Teri

￥17,696 total

includes taxes & fees

Nov 23 - Nov 24

A spacious living area with a kitchen, modern furniture, and a fireplace.

16. Fountain Park Hotel, BW Signature Collection

7.2 km from Mayo Clinic

Glen

￥21,698 total

includes taxes & fees

Nov 30 - Dec 1

A spacious lobby with a fireplace, seating areas, and large windows.

17. Hilton Garden Inn Phoenix Airport North

24.2 km from Mayo Clinic

david

￥16,732 total

includes taxes & fees

Nov 22 - Nov 23

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

18. Hyatt House North Scottsdale

14.2 km from Mayo Clinic

Katherine

￥27,668 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor seating area with sofas, chairs, and a fire pit.

19. Home2 Suites by Hilton Phoenix Airport North, AZ

23.1 km from Mayo Clinic

Mark

￥16,732 total

includes taxes & fees

Nov 22 - Nov 23

A modern hotel room with a grey sofa, a round table, a bed with white linens, a large abstract painting, a floor lamp, and a window with curtains.

20. Hyatt Place Tempe Phoenix Airport

23.5 km from Mayo Clinic

dularie

￥16,879 total

includes taxes & fees

Nov 23 - Nov 24

View all properties

Compare popular hotels in Mayo Clinic

Property	Star rating	Guest rating
Sonesta Select Scottsdale at Mayo Clinic Campus	3.0 star property	8.4 Very good 1,080 reviews	View
Talking Stick Resort	4.0 star property	9.4 Exceptional 5,198 reviews	View
Inn at Eagle Mountain	3.5 star property	9.0 Wonderful 1,042 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	2.5 star property	9.2 Wonderful 2,073 reviews	View
Fountain Park Hotel, BW Signature Collection	3.0 star property	9.0 Wonderful 1,000 reviews	View

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most.

A cityscape with prominent buildings including a Chase bank and The Arizona Republic building.

Downtown Phoenix

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

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A fountain with three horses, surrounded by red flowers and storefronts.

Old Town

Old Town is known for its popular shops, and you can see some sights in the area like Scottsdale Waterfront and Western Spirit: Scottsdale's Museum of the West.

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A hiker on a rocky trail with mountains in the background.

Rio Verde Foothills

If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Golf Club Scottsdale and Tom's Thumb Trail.

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A rocky hill with palm trees and a body of water.

Camelback East

Adjacent to Paradise Valley and Scottsdale, Camelback East Village boasts two main cores and sits between Piestewa Peak and Camelback Mountain. Explore the vibrant 24th Street and Camelback Road or 44th Street and Van Buren Street areas.

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A mountainous landscape with a city in the valley below.

North Phoenix

While you're in North Phoenix, take in top sights like Reach 11 Sports Complex and jump on the metro at 19th Avenue/ Dunlap Station to see more of the city.

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Top Mayo Clinic Hotel Reviews

Sonesta Select Scottsdale at Mayo Clinic Campus

Central Scottsdale

10/10 Excellent

James

Comfort Suites Scottsdale Talking Stick Entertainment District

Scottsdale

10/10 Excellent

Darla

Inn at Eagle Mountain

Eagle Mountain

10/10 Excellent

carla

A modern interior with a sectional sofa, round coffee table, and a seating area with a view of the outside.

The 233 Suites Unscripted by Hyatt

Downtown

10/10 Excellent

Greg

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale

10/10 Excellent

Raymond

A swimming pool with a tiled deck, lounge chairs, and palm trees.

Best Western Plus Gilbert/Mesa

US 60 Corridor

10/10 Excellent

Keith

Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark

10/10 Excellent

This property is very well managed. We were there 5 nights and gave it a top rating because the rooms were spacious with a sitting area, it's clean, the breakfast and breakfast service was excellent, the pool and grounds were well maintained, and the workout facility was adequate. The front desk was staffed 24/7 It's not a new facility and the furnishings are dated, but everything worked. For North Scottsdale is a good value and we'll be returning there again on our next trip.

J

Hyatt Place Scottsdale - North

Scottsdale

10/10 Excellent

Yoana

A modern hotel with a brick facade, large windows, and a covered entrance area.

Springhill Suites Phoenix Scottsdale Marriott

Scottsdale

10/10 Excellent

Anna

A hotel room with two beds, a TV, a desk, a chair, and a view of palm trees.

Hyatt Place Phoenix/Mesa

Riverview

10/10 Excellent

Gina

An outdoor seating area with a fire pit, surrounded by chairs and tables, under string lights.

Hilton Vacation Club Scottsdale Links Resort

Scottsdale Links

10/10 Excellent

peter

An outdoor dining area with tables and chairs, surrounded by trees and a view of a mountain.

Mountain Shadows Resort Scottsdale

Paradise Valley

10/10 Excellent

Rachael

Hyatt House North Scottsdale

Scottsdale

10/10 Excellent

Alexander

A swimming pool with people on inflatable floats, lounge chairs, and umbrellas in the background.

Wekopa Casino Resort

Fort McDowell

10/10 Excellent

Helen

Frequently Asked Questions

What is Mayo Clinic like?

Travelers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighborhood.

Where is the best place to stay in Mayo Clinic?

Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.

How many hotels will I be able to find in the Mayo Clinic area?

With 14 Expedia hotels and other accommodations in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.

If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?

Yes! Most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in Mayo Clinic.

Where can I learn more about changing or cancelling my trip to Mayo Clinic?

For more information about updating your trip to Mayo Clinic or cancelling it, go to https://www.expedia.com/service/.

What is there to do around this Scottsdale neighborhood?

A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain, and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.

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Find hotels in Mayo Clinic, Phoenix from ￥13,753

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Property class

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Our top choices for Mayo Clinic hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Comfort Suites Scottsdale Talking Stick Entertainment District

3. Talking Stick Resort

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

5. Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

6. Aiden by Best Western Scottsdale North

7. Hyatt Place Scottsdale - North

8. Best Western Plus Scottsdale Thunderbird Suites

9. Inn at Eagle Mountain

10. Courtyard by Marriott Scottsdale North

11. Hilton Phoenix Airport

12. Holiday Inn Club Vacations Scottsdale Resort by IHG

13. Sonesta Suites Scottsdale Gainey Ranch

14. Holiday Inn Hotel & Suites PHOENIX AIRPORT by IHG

15. Holiday Inn Express & Suites Phoenix - Airport North by IHG

16. Fountain Park Hotel, BW Signature Collection

17. Hilton Garden Inn Phoenix Airport North

18. Hyatt House North Scottsdale

19. Home2 Suites by Hilton Phoenix Airport North, AZ

20. Hyatt Place Tempe Phoenix Airport

Compare popular hotels in Mayo Clinic

Where to stay in Mayo Clinic

Downtown Phoenix

Old Town

Rio Verde Foothills

Camelback East

North Phoenix

Top Mayo Clinic Hotel Reviews

Sonesta Select Scottsdale at Mayo Clinic Campus

10/10 Excellent

Frequently Asked Questions

What is Mayo Clinic like?

Where is the best place to stay in Mayo Clinic?

How many hotels will I be able to find in the Mayo Clinic area?

If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Mayo Clinic?

What is there to do around this Scottsdale neighborhood?

Explore a world of travel with Expedia