Find hotels in Mayo Clinic, Phoenix from ￥14,153

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Our top choices for Mayo Clinic hotels

Lobby lounge
Sonesta Select Scottsdale at Mayo Clinic Campus

Sonesta Select Scottsdale at Mayo Clinic Campus

Sonesta Select Scottsdale at Mayo Clinic Campus
3.0 star property
Mayo Clinic
8.2 out of 10, Very Good, (1059)
"Very clean and very friendly staff "
United States
Michelle
The price is ￥15,346
￥17,491 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Sonesta Select Scottsdale at Mayo Clinic Campus
Water park
Arizona Grand Resort & Spa

Arizona Grand Resort & Spa

Arizona Grand Resort & Spa
4.0 star property
28.6 km from Mayo Clinic
8.6 out of 10, Excellent, (2298)
"Great hotel! I stayed at the Villas and highly recommend. Very clean with lots of amazing amenities including golf and water park."
United States
ALONA
The price is ￥14,548
￥30,449 total
includes taxes & fees
Dec 23 - Dec 24
Arizona Grand Resort & Spa
Outdoor pool
The Westin Tempe

The Westin Tempe

The Westin Tempe
4.0 star property
22.7 km from Mayo Clinic
9.4 out of 10, Exceptional, (1002)
"My stay was amazing and the hotel was pretty clean."
United States
Melody
The price is ￥15,787
￥22,960 total
includes taxes & fees
Dec 21 - Dec 22
The Westin Tempe
Exterior
Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort
4.0 star property
25.4 km from Mayo Clinic
8.6 out of 10, Excellent, (2206)
"Staff were super nice and hotel was great "
Canada
Ryder Michael
The price is ￥16,372
￥25,306 total
includes taxes & fees
Dec 23 - Dec 24
Hilton Phoenix Tapatio Cliffs Resort
3 outdoor pools, a heated pool, cabanas (surcharge), pool umbrellas
Scottsdale Plaza Resort & Villas (soon to be Kimpton)

Scottsdale Plaza Resort & Villas (soon to be Kimpton)

Scottsdale Plaza Resort & Villas (soon to be Kimpton)
4.0 star property
13.5 km from Mayo Clinic
8.8 out of 10, Excellent, (2180)
"Beautiful place to stay! "
United States
Jaycee
The price is ￥22,643
￥32,311 total
includes taxes & fees
Dec 21 - Dec 22
Scottsdale Plaza Resort & Villas (soon to be Kimpton)
Outdoor pool, open 6:00 AM to 11:00 PM, pool umbrellas, sun loungers
Hyatt Place Tempe / Phoenix / University

Hyatt Place Tempe / Phoenix / University

Hyatt Place Tempe / Phoenix / University
3.0 star property
22.1 km from Mayo Clinic
9.2 out of 10, Wonderful, (1131)
"Clean, comfy beds, great breakfast."
United States
Alyssa
The price is ￥15,632
￥17,830 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hyatt Place Tempe / Phoenix / University
Lobby
Hilton Garden Inn Phoenix Airport North

Hilton Garden Inn Phoenix Airport North

Hilton Garden Inn Phoenix Airport North
3.0 star property
24.2 km from Mayo Clinic
8.6 out of 10, Excellent, (2294)
"Check-in was very easy, and helpful staff."
United States
Cindy
The price is ￥13,326
￥15,067 total
includes taxes & fees
Dec 25 - Dec 26
Hilton Garden Inn Phoenix Airport North
2 restaurants, American cuisine
Cambria Hotel Downtown Phoenix Convention Center

Cambria Hotel Downtown Phoenix Convention Center

Cambria Hotel Downtown Phoenix Convention Center
3.0 star property
29.3 km from Mayo Clinic
9.0 out of 10, Wonderful, (1218)
"Property was clean, staff were friendly. "
United States
Sophia
The price is ￥14,141
￥15,989 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Cambria Hotel Downtown Phoenix Convention Center
2 restaurants, breakfast, lunch, dinner served; American cuisine
Omni Tempe Hotel at ASU

Omni Tempe Hotel at ASU

Omni Tempe Hotel at ASU
4.0 star property
22.8 km from Mayo Clinic
9.4 out of 10, Exceptional, (1315)
"Great rooms and room service!"
United States
Atharva
The price is ￥20,925
￥28,283 total
includes taxes & fees
Dec 21 - Dec 22
Omni Tempe Hotel at ASU
Outdoor pool, open 7:00 AM to 10:00 PM, sun loungers
DoubleTree Suites by Hilton Phoenix

DoubleTree Suites by Hilton Phoenix

DoubleTree Suites by Hilton Phoenix
4.0 star property
23.5 km from Mayo Clinic
8.4 out of 10, Very Good, (1661)
"Location close to airport, yet quiet from the planes. Breakfast and dinner in-hotel dinning was excellent. Hotel shuttle to and from airport was very good. Highly recommend for business travel; woukd choose to stay there again!"
United States
Monthien
The price is ￥14,118
￥15,962 total
includes taxes & fees
Dec 25 - Dec 26
DoubleTree Suites by Hilton Phoenix
In-room safe, individually decorated, individually furnished
Rise Uptown Hotel

Rise Uptown Hotel

Rise Uptown Hotel
4.0 star property
27.9 km from Mayo Clinic
9.2 out of 10, Wonderful, (1117)
"Great staff, great rooms."
United States
Robert
The price is ￥20,214
￥27,932 total
includes taxes & fees
Dec 22 - Dec 23
Rise Uptown Hotel
Outdoor pool
Best Western Downtown Phoenix

Best Western Downtown Phoenix

Best Western Downtown Phoenix
2.5 star property
29.3 km from Mayo Clinic
8.6 out of 10, Excellent, (1001)
"It was perfectly located. The room was comfortable, and the breakfast was great."
United States
Jennifer
The price is ￥12,517
￥14,153 total
includes taxes & fees
Dec 23 - Dec 24
Best Western Downtown Phoenix
Exterior
Hampton Inn & Suites Phoenix Downtown

Hampton Inn & Suites Phoenix Downtown

Hampton Inn & Suites Phoenix Downtown
3.0 star property
30 km from Mayo Clinic
9.2 out of 10, Wonderful, (1704)
"Great location and all the staff were very friendly! "
United States
Alma
The price is ￥18,449
￥20,860 total
includes taxes & fees
Dec 22 - Dec 23
Hampton Inn & Suites Phoenix Downtown
Banquet hall
The McCormick Scottsdale

The McCormick Scottsdale

The McCormick Scottsdale
3.5 star property
13 km from Mayo Clinic
8.4 out of 10, Very Good, (1281)
"Excellent stay!"
United States
Kim
The price is ￥12,866
￥19,965 total
includes taxes & fees
Dec 25 - Dec 26
The McCormick Scottsdale
2 restaurants, breakfast, lunch, dinner served; American cuisine
Hyatt Regency Phoenix

Hyatt Regency Phoenix

Hyatt Regency Phoenix
4.0 star property
30 km from Mayo Clinic
9.2 out of 10, Wonderful, (1858)
"Everything was great "
United States
Julieta
The price is ￥19,965
￥26,949 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt Regency Phoenix
Courtyard
Papago Scottsdale by Reside, Trademark Collection by Wyndham

Papago Scottsdale by Reside, Trademark Collection by Wyndham

Papago Scottsdale by Reside, Trademark Collection by Wyndham
3.0 star property
18.5 km from Mayo Clinic
8.6 out of 10, Excellent, (263)
"Awesome place "
United States
Tyler
The price is ￥13,001
￥14,818 total
includes taxes & fees
Dec 30 - Dec 31
Papago Scottsdale by Reside, Trademark Collection by Wyndham
Exterior
Hilton Garden Inn Scottsdale Old Town

Hilton Garden Inn Scottsdale Old Town

Hilton Garden Inn Scottsdale Old Town
3.0 star property
Brown and Stetson Business, 15.8 km from Mayo Clinic
9.0 out of 10, Wonderful, (1004)
"Great place to stay ,close to everything "
United States
Desiree
The price is ￥16,397
￥18,689 total
includes taxes & fees
Dec 27 - Dec 28
Hilton Garden Inn Scottsdale Old Town
Pillowtop beds, desk, blackout drapes, iron/ironing board
Radisson Hotel Phoenix Airport

Radisson Hotel Phoenix Airport

Radisson Hotel Phoenix Airport
3.5 star property
23.3 km from Mayo Clinic
8.6 out of 10, Excellent, (1827)
"Hotel was clean and staff was very friendly."
United States
Kenneth
The price is ￥15,679
￥17,729 total
includes taxes & fees
Dec 23 - Dec 24
Radisson Hotel Phoenix Airport
Free daily buffet breakfast
Hyatt Place Tempe Phoenix Airport

Hyatt Place Tempe Phoenix Airport

Hyatt Place Tempe Phoenix Airport
3.0 star property
23.5 km from Mayo Clinic
9.0 out of 10, Wonderful, (1045)
"The room was clean and cozy, the breakfast was delicious with a good variety of fruits and other breakfast items!"
United States
Reagan
The price is ￥13,021
￥14,853 total
includes taxes & fees
Dec 23 - Dec 24
Hyatt Place Tempe Phoenix Airport
Exterior
Talking Stick Resort

Talking Stick Resort

Talking Stick Resort
4.0 star property
9 km from Mayo Clinic
9.2 out of 10, Wonderful, (4195)
"Amazing place to visit"
United States
Victor
The price is ￥22,147
￥29,664 total
includes taxes & fees
Dec 22 - Dec 23
Talking Stick Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most.
Downtown Phoenix which includes signage and night scenes

Downtown Phoenix

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

Old Town

Old Town

Old Town is known for its popular shops, and you can see some sights in the area like Western Spirit: Scottsdale's Museum of the West and Fiesta Bowl Museum.

Papago Park featuring desert views as well as a small group of people

Camelback East

Adjacent to Paradise Valley and Scottsdale, Camelback East Village boasts two main cores and sits between Piestewa Peak and Camelback Mountain. Explore the vibrant 24th Street and Camelback Road or 44th Street and Van Buren Street areas.

East Mesa

While you're in East Mesa, take in top sights like Salt River Tubing and jump on the metro at Superstition Springs Transit Center to see more of the city.

Central Scottsdale

While visiting Central Scottsdale, you might make a stop by sights like Scottsdale Ranch Park and Starfire Golf Club at Scottsdale Country Club.

Top Mayo Clinic Hotel Reviews

Arizona Grand Resort & Spa

Arizona Grand Resort & Spa

10/10 Excellent
"Great hotel! I stayed at the Villas and highly recommend. Very clean with lots of amazing amenities including golf and water park."
ALONA 5-night trip
Posted 23 hours ago
Arizona Grand Resort & Spa

Explore a world of travel with Expedia

Frequently asked questions

What is Mayo Clinic like?
Travelers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighborhood.
Where is the best place to stay in Mayo Clinic?
Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.
How many hotels will I be able to find in the Mayo Clinic area?
With 14 Expedia hotels and other accommodations in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.
If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?
Yes! Most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in Mayo Clinic.
Where can I learn more about changing or cancelling my trip to Mayo Clinic?
For more information about updating your trip to Mayo Clinic or cancelling it, go to https://www.expedia.com/service/.
What is there to do around this Scottsdale neighborhood?
A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain, and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.