Enterprise Car Rentals in James Island

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    Change your mind

    Penalty-free cancellation on many/select car rentals
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    Treat yourself

    Members save 10% or more on over 1 million car rentals
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    Shop smart

    Compare car suppliers to unlock big savings

At Expedia, we are proud to work with Enterprise due to their history of superior customer service as well their large fleet of premier vehicles. Start browsing through the great selection of rental cars by entering your search preferences into our online booking wizard and sorting through everything from spacious SUVs to compact luxury cars. Meaning, whether you need an economy car for a quick business trip or a roomy vehicle to fit the entire family on a long road trip, we’ve got you covered. And, what’s more, we always offer Enterprise James Island cars at the lowest possible prices. Our prices on Enterprise rentals in James Island can’t be beat. Get started and peruse our myriad of cheap deals and discounts on rental cars for your time in James Island today.