Photo by Jessica King
Find hotels in De Soto, MO from ¥8,797
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in De Soto
Cabin
Apartment
Check prices for these dates
Compare 171 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Super 8 by Wyndham Farmington
Super 8 by Wyndham Farmington
8.0 out of 10, Very Good, (598)
The price is ¥7,796
¥8,876 total
includes taxes & fees
Nov 3 - Nov 4

Super 8 by Wyndham Potosi
Super 8 by Wyndham Potosi
7.0 out of 10, Good, (371)
The price is ¥8,055
¥8,797 total
includes taxes & fees
Oct 28 - Oct 29

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
9.4 out of 10, Exceptional, (688)
The price is ¥19,413
¥22,199 total
includes taxes & fees
Nov 2 - Nov 3

Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Arnold
9.2 out of 10, Wonderful, (1002)
The price is ¥13,756
¥15,901 total
includes taxes & fees
Nov 2 - Nov 3

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
8.0 out of 10, Very Good, (1010)
The price is ¥8,560
¥9,747 total
includes taxes & fees
Nov 3 - Nov 4

Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
7.8 out of 10, Good, (896)
The price is ¥12,214
¥14,272 total
includes taxes & fees
Nov 2 - Nov 3
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular De Soto attractions
Learn more about De Soto
Get away to De Soto! Enjoy the local cuisine and more.

Photo by Jessica King
Open Photo by Jessica King
More cheap stays in De Soto

Pear Tree Inn St. Louis Arnold
1201 Drury Ln, Arnold, MO
The price is ¥13,756 per night from Nov 2 to Nov 3
¥13,756
¥15,901 total
Nov 2 - Nov 3
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
Frequently asked questions
Explore a world of travel with Expedia
Stay near popular De Soto attractions
Hotels near De Soto Airports
Other Hotels near De Soto, Missouri
- Fenton Hotels
- Eureka Hotels
- Farmington Hotels
- Ozarks Hotels
- Festus Hotels
- Arnold Hotels
- Southern Illinois Hotels
- Ste Genevieve Hotels
- Sullivan Hotels
- Oakville Hotels
- Pacific Hotels
- St. Clair Hotels
- Union Hotels
- Waterloo Hotels
- Potosi Hotels
- Bonne Terre Hotels
- Tesson Ferry Hotels
- Imperial Hotels
- Bourbon Hotels
- Southeast Missouri Hotels
Explore more hotels
More ways to book
Expedia's Latest Trends
Hotels


















































































