A bench, a bicycle, and a lake surrounded by trees.

Find 4 Star Hotels in Upstate South Carolina, SC from ￥18,596

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
Sep 24 - Sep 25
Tomorrow
Sep 25 - Sep 26
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Upstate South Carolina 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.
A modern interior with a fireplace, plush seating, and a stone accent wall.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
Michael
￥61,567
￥69,756 total
includes taxes & fees
Oct 4 - Oct 5
Grand Bohemian Lodge Greenville, Autograph Collection
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A bar with multiple shelves of liquor bottles and glasses hanging above.
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.

2. Hotel Hartness

Hotel Hartness
Greenville
United States
Cornelius
￥24,087
￥32,513 total
includes taxes & fees
Sep 27 - Sep 28
Hotel Hartness
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A banquet hall with round tables, chandeliers, and ornate windows.
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
￥26,748
￥30,779 total
includes taxes & fees
Oct 18 - Oct 19
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Gregory
￥16,906
￥18,596 total
includes taxes & fees
Sep 29 - Sep 30
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

5. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
￥23,712
￥26,319 total
includes taxes & fees
Oct 11 - Oct 12
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
An outdoor patio with wicker furniture, a round table, and a fountain.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
￥32,086
￥35,614 total
includes taxes & fees
Oct 7 - Oct 8
The Shepherd Hotel Downtown Clemson
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.
A well-furnished living room with a chandelier, wooden furniture, and a view through a window.

7. Greenville Marriott

Greenville Marriott
Greenville
United States
John
￥19,309
￥21,875 total
includes taxes & fees
Oct 11 - Oct 12
Greenville Marriott
A white, two-story house with a front porch, surrounded by trees and shrubs.
A dining area with round tables, black chairs, and white tablecloths.
A bedroom with two beds, a TV, and a fireplace.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.

8. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
Christine
￥19,629
￥21,787 total
includes taxes & fees
Sep 27 - Sep 28
Liberty Hall Bed and Breakfast
A modern building with outdoor seating and a garden.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.
A row of modern, two-story buildings with a covered patio area.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.

9. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveler
￥39,973
￥57,027 total
includes taxes & fees
Sep 27 - Sep 28
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A swimming pool with lounge chairs and a building with balconies.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.

10. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
￥66,315
￥72,947 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.
A modern kitchen with dark cabinetry, a stainless steel range, and a granite countertop.
A multi-story residential building with balconies, a stone archway entrance, and a sign indicating it is part of Century Park at Taft Community.

11. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A multi-story building with a symmetrical facade, large windows, and two flags on top.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.

12. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A spacious living area with a high ceiling, wooden beams, a grey sofa, a brown leather chair, and a dining table with a plant.
A cozy living room with a fireplace, leather armchair, and a large window.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.

13. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
A lakeside property with a marina, multiple buildings, and surrounding greenery.
A lakeside property with a dock and boats, surrounded by dense forest and a clear view of the lake.
A wooden deck with a railing, overlooking a forested area with trees and a building in the background.

14. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A swimming pool with a view of the lake and docked boats.
A modern kitchen with a central island, stainless steel appliances, wooden cabinets, and a window providing natural light.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A modern living room with a large window, a flat-screen TV, a leather sofa, a coffee table, and a bookshelf.

15. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A multi-story hotel with a parking lot and a view of a lake.
A marina with boats docked, a wooden pier, and a clear sky.
A hallway with a wooden bench, a chandelier, a door, and a wall with a sign.

16. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.
A modern living room with a sofa, a coffee table, and a fireplace.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.

17. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A sandy beach with a calm lake surrounded by trees.
A multi-story hotel with a parking lot and a view of a lake.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A marina with boats docked, surrounded by greenery and trees.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.

19. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A large indoor swimming pool with clear lanes, a covered roof, and seating areas along the sides.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.
An aerial view of a residential area with houses, a golf course, and a lake in the background.

20. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Frankie's Fun Park to Conestee Nature Preserve.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"Beautiful hotel with all the amenities! Large rooms and bathrooms, great coffee maker and steamer for clothes. Beautiful views outside of restaurant. Will definitely return!"
Eric 2-night trip
Posted 2 days ago
Grand Bohemian Lodge Greenville, Autograph Collection

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.
  • Search for the lowest price from ￥18,596
What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

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