The Best Resorts & Hotels with Spas in Upstate South Carolina, SC from ￥17,159 in 2026

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Our top choices for Upstate South Carolina hotels with a spa

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Greenville Downtown

Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.

￥62,795 total

includes taxes & fees

Nov 29 - Nov 30

A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.

2. Hotel Hartness

Greenville

Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.

￥34,713 total

includes taxes & fees

Nov 22 - Nov 23

A two-story house with a tiled roof, a stone fire pit, and outdoor seating.

3. Hotel Domestique

Travelers Rest

Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.

￥73,048 total

includes taxes & fees

Nov 15 - Nov 16

A two-story house with a covered porch, a front entrance, and a landscaped garden.

4. Bed & Breakfast on Tiffany Hill

Mills River

￥48,207 total

includes taxes & fees

Nov 8 - Nov 9

A wooden deck with outdoor seating, surrounded by trees.

5. Lake Rabun Hotel & Restaurant

Lakemont

Soak in therapeutic massages and mountain tranquility at this historic boutique hotel nestled near Tallulah Gorge State Park.

￥20,696 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a bed, a bedside lamp, and a small table with candles.

6. Greystone Inn

Lake Toxaway

Soak in mountain views at this lakeside retreat with couples' spa treatment rooms, yoga classes, and deep-tissue massages.

￥52,910 total

includes taxes & fees

Dec 1 - Dec 2

A hotel room with two beds, a desk, a chair, a mirror, and a window with curtains.

7. 1898 Waverly Inn

Hendersonville

Experience spa bliss at this charming B&B with relaxing massage treatment rooms and attentive staff who ensure a rejuvenating stay.

￥20,037 total

includes taxes & fees

Nov 8 - Nov 9

A wooden bridge over a small water feature with a large water wheel in the background.

8. Sylvan Falls Mill B&B

Rabun Gap

Serene mountain retreat offers restorative massages in a garden setting, steps away from Chattahoochee National Forest.

￥37,346 total

includes taxes & fees

Nov 9 - Nov 10

A two-story wooden cabin with a balcony, a swimming pool, and a deck area.

9. Glen-Ella Springs Hotel & Restaurant

Clarkesville

Relaxing country retreat with in-room massages and a serene garden setting for a rejuvenating spa experience.

￥38,142 total

includes taxes & fees

Nov 10 - Nov 11

A golf course with a clubhouse, multiple buildings, and a large swimming pool.

10. SKYLARANNA Resort & Spa

Hendersonville

Rejuvenate in a mountain spa retreat with 3 dedicated treatment rooms, hot tubs, and aromatherapy services along a scenic river.

￥28,703 total

includes taxes & fees

Nov 15 - Nov 16

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Choose what matters most at spa hotels in Upstate South Carolina

Pool

Breakfast included

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

Greenville

10/10 Excellent

Gracie

Hotel Domestique

Travelers Rest

10/10 Excellent

This hotel is amazing!!! My husband and I decided to do an impromptu anniversary getaway and were so lucky to find this hotel. It reminded us of our honeymoon in Italy. The staff goes above and beyond with anything you might need. Dinner at the 17 restaurant on property was also unforgettable and so yummy. The only negative I hope the hotel makes better before our next visit would be the pool. Yes this is a hotel with only 13 rooms, but the pool should have more than 7 lounge chairs (Some of...

jamie leigh

A two-story house with a porch, a covered outdoor seating area, and a dog in the yard.

The Orchard Inn

Saluda

10/10 Excellent

Just driving up to the Orchard Inn took my breath away. It's a beautiful, Victorian building in a mountain forest. When we walked inside we were immediately struck by the view across the room -- an enclosed veranda that overlooks amazing flowers and very busy birdfeeders with a stunning valley view beyond. The staff is wonderful and they truly make you feel at home. Our room was comfortable, clean and spacious. I took advantage of the invitation to join the owner on a morning walk with their...

Nanci

The Horse Shoe Farm

Hendersonville

10/10 Excellent

Robert

1898 Waverly Inn

Hendersonville

10/10 Excellent

Julie

Glen-Ella Springs Hotel & Restaurant

Clarkesville

10/10 Excellent

John

Sylvan Falls Mill B&B

Rabun Gap

10/10 Excellent

It is a still working mill and together Mike and Linda team up to provide excellent and healthy food using the mill as well and old cook books. Dinner was fabulous and breakfast was a surprise each time. The house is old obviously, but is kept very clean. We even got clean towels daily! We certainly recommend to have a romantic dinner on the day of arrival sitting at the porch overlooking the waterfall!

Anje

A cozy living room with a fireplace, a sofa, a leather ottoman, and a chandelier.

Morgan and Wells B&B

Shelby

10/10 Excellent

Anonymous traveler

A large, two-story building with a stone facade and a spacious lawn with lounge chairs.

Echo Mountain Inn

Hendersonville

10/10 Excellent

Jim&Lisa

Lake Rabun Hotel & Restaurant

Lakemont

10/10 Excellent

Anonymous traveler

SKYLARANNA Resort & Spa

Hendersonville

10/10 Excellent

Heather

Bed & Breakfast on Tiffany Hill

Mills River

10/10 Excellent

Freida

Find out more about Upstate South Carolina

Top Upstate South Carolina attractions for a relaxing vacation

Upstate South Carolina is a hidden gem for travelers seeking rejuvenating spa experiences paired with thrilling outdoor adventures. Start your journey in Greenville, where the picturesque Falls Park on the Reedy offers stunning natural beauty and tranquil walking paths, perfect for a serene morning walk before indulging in a spa day. Just a short drive away, the Blue Ridge Mountains beckon with breathtaking hiking trails and scenic overlooks, providing both adventure and a connection to nature. For a taste of culture, visit the Greenville County Museum of Art, home to an impressive collection of American art, where you can immerse yourself in creativity before unwinding at a local spa. If you’re looking for relaxation and wellness, the luxurious hotels in the area, such as the Westin Poinsett or the Hyatt Regency, boast on-site spas that offer everything from massages to rejuvenating facials, ensuring you feel pampered throughout your stay. With a blend of outdoor exploration and high-quality spa experiences, Upstate South Carolina invites families to enjoy both adventure and relaxation together.

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Find Resorts & Hotels with Spas in Upstate South Carolina, SC

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Upstate South Carolina hotels with a spa

1. Grand Bohemian Lodge Greenville, Autograph Collection

2. Hotel Hartness

3. Hotel Domestique

4. Bed & Breakfast on Tiffany Hill

5. Lake Rabun Hotel & Restaurant

6. Greystone Inn

7. 1898 Waverly Inn

8. Sylvan Falls Mill B&B

9. Glen-Ella Springs Hotel & Restaurant

10. SKYLARANNA Resort & Spa

Choose what matters most at spa hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

10/10 Excellent

Find out more about Upstate South Carolina

Top Upstate South Carolina attractions for a relaxing vacation

Explore a world of travel with Expedia