A bench, a bicycle, and a lake surrounded by trees.

Find Resorts & Hotels with Spas in Upstate South Carolina, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina Resorts & Hotels with Spas

Tonight
Oct 24 - Oct 25
Tomorrow
Oct 25 - Oct 26
Next weekend
Oct 30 - Nov 1
In two weeks
Nov 6 - Nov 8

Our top choices for Upstate South Carolina hotels with a spa

A spa room with two beds, a mural, and a reception desk.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.
A modern interior with a fireplace, plush seating, and a stone accent wall.
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
  • Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
￥54,856
￥62,151 total
includes taxes & fees
Nov 23 - Nov 24
Grand Bohemian Lodge Greenville, Autograph Collection
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A cozy lounge area with leather armchairs, a central table, and a fireplace.
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.

2. Hotel Hartness

Hotel Hartness
Greenville
  • Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
￥25,760
￥34,359 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Hartness
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A reception area with a wooden reception desk, a large abstract painting, and a potted plant.
A bar with a large window view of mountains and a chandelier.
A swimming pool with lounge chairs and a building with balconies.

3. Hotel Domestique

Hotel Domestique
Travelers Rest
  • Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
￥65,670
￥72,237 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Domestique
A two-story house with a covered porch, a front entrance, and a landscaped garden.
Exterior
Interior
Interior

4. Bed & Breakfast on Tiffany Hill

Bed & Breakfast on Tiffany Hill
Mills River
￥45,179
￥50,939 total
includes taxes & fees
Nov 24 - Nov 25
Bed & Breakfast on Tiffany Hill
A hotel room with two beds, wooden walls, and a window.
A stone pathway leading to a rustic wooden building surrounded by trees.
A rustic wooden room with a wooden door, a small table with a lamp, a chair, and a window with curtains.
A rustic cabin with a covered porch, surrounded by trees.

5. Lake Rabun Hotel & Restaurant

Lake Rabun Hotel & Restaurant
Lakemont
  • Soak in therapeutic massages and mountain tranquility at this historic boutique hotel nestled near Tallulah Gorge State Park.
￥17,792
￥21,423 total
includes taxes & fees
Nov 3 - Nov 4
Lake Rabun Hotel & Restaurant
A two-story wooden cabin with a balcony, a swimming pool, and a deck area.
A wooden interior with tables and chairs, a fireplace, and a stone wall.
A covered porch with rocking chairs and a small table with flowers.
A cozy room with a bed, a chair, a tray with snacks and wine, and a view of the outdoors.

6. Glen-Ella Springs Hotel & Restaurant

Glen-Ella Springs Hotel & Restaurant
Clarkesville
  • Relaxing country retreat with in-room massages and a serene garden setting for a rejuvenating spa experience.
￥33,037
￥37,785 total
includes taxes & fees
Oct 25 - Oct 26
Glen-Ella Springs Hotel & Restaurant
A hotel room with a bed, a bedside lamp, and a small table with candles.
A stone staircase leading to a house with a stone chimney and a small glass door.
A swimming pool with lounge chairs and umbrellas, surrounded by autumn trees and a lake view.
A lakeside lodge with outdoor seating and string lights.

7. Greystone Inn

Greystone Inn
Lake Toxaway
  • Soak in mountain views at this lakeside retreat with couples' spa treatment rooms, yoga classes, and deep-tissue massages.
￥51,610
￥62,935 total
includes taxes & fees
Nov 23 - Nov 24
Greystone Inn
A hotel room with two beds, a desk, a chair, a mirror, and a window with curtains.
A modern bathroom with a glass shower enclosure, a white toilet, and a sink with a mirror above it.
A bedroom with a bed, a ceiling fan, a bedside table, and a nightstand.
A dining area with checkered flooring, multiple tables and chairs, and a decorative cabinet with various items.

8. 1898 Waverly Inn

1898 Waverly Inn
Hendersonville
  • Experience spa bliss at this charming B&B with relaxing massage treatment rooms and attentive staff who ensure a rejuvenating stay.
￥20,102
￥22,664 total
includes taxes & fees
Nov 24 - Nov 25
1898 Waverly Inn
A reception desk with a logo, a Buddha statue, a vase, and a door labeled 'EMPLOYEES ONLY'.
A bedroom with a bed, a nightstand, a lamp, and a view of a balcony with outdoor furniture.
A breakfast plate with eggs, bacon, and fries, a coffee cup, and a glass of water on a table with a view of a pool and mountains.
A bedroom with a bed, a nightstand, a window with curtains, and a view of the outside.

9. SKYLARANNA Resort & Spa

SKYLARANNA Resort & Spa
Hendersonville
  • Rejuvenate in a mountain spa retreat with 3 dedicated treatment rooms, hot tubs, and aromatherapy services along a scenic river.
￥20,947
￥28,919 total
includes taxes & fees
Oct 27 - Oct 28
SKYLARANNA Resort & Spa
A round table set for four with wicker chairs, a white tablecloth, and a view of a forested area through large windows.
A wooden bridge over a small water feature with a large water wheel in the background.
A cozy living room with a large window, a fireplace, and various plants.
A bathroom with a shower area, a toilet, and a sink.

10. Sylvan Falls Mill B&B

Sylvan Falls Mill B&B
Rabun Gap
  • Serene mountain retreat offers restorative massages in a garden setting, steps away from Chattahoochee National Forest.
￥31,189
￥36,963 total
includes taxes & fees
Nov 3 - Nov 4
Sylvan Falls Mill B&B
View all properties

Choose what matters most at spa hotels in Upstate South Carolina

Pool
Breakfast included
Hot tub
4 stars
5 stars

Find out more about Upstate South Carolina

Top Upstate South Carolina attractions for a relaxing vacation

Upstate South Carolina is a hidden gem for travelers seeking rejuvenating spa experiences paired with thrilling outdoor adventures. Start your journey in Greenville, where the picturesque Falls Park on the Reedy offers stunning natural beauty and tranquil walking paths, perfect for a serene morning walk before indulging in a spa day. Just a short drive away, the Blue Ridge Mountains beckon with breathtaking hiking trails and scenic overlooks, providing both adventure and a connection to nature. For a taste of culture, visit the Greenville County Museum of Art, home to an impressive collection of American art, where you can immerse yourself in creativity before unwinding at a local spa. If you’re looking for relaxation and wellness, the luxurious hotels in the area, such as the Westin Poinsett or the Hyatt Regency, boast on-site spas that offer everything from massages to rejuvenating facials, ensuring you feel pampered throughout your stay. With a blend of outdoor exploration and high-quality spa experiences, Upstate South Carolina invites families to enjoy both adventure and relaxation together.

Top Upstate South Carolina Hotel Reviews

Hilton Greenville

Hilton Greenville

10/10 Excellent
"Location is great for getting to/from downtown area"
William 1-night trip
Posted 11 hours ago
Hilton Greenville
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent
"My stay at Embassy Suites was great. My room was clean the floor level I requested was very convenient the staff was helpful and gracious. the area was nice with near by stores surrounding the area, Overall it was great and I would definitely come back."
Jeanette 1-night trip
Posted 13 hours ago
Embassy Suites Greenville Golf Resort & Conference Center

Explore a world of travel with Expedia