Find Boutique Hotels in Southwest Ohio, OH

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Check availability on Southwest Ohio Boutique Hotels

Our top choices for Southwest Ohio boutique hotels

Egyptian cotton sheets, premium bedding, in-room safe, laptop workspace
21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

4.5 star property
Downtown Cincinnati
8.6 out of 10, Excellent, (1007)
"Very clean rooms, great bar, friendly staff."
United States
Theodore
The price is ￥22,313
￥27,396 total
includes taxes & fees
Jan 2 - Jan 3, 2026
21c Museum Hotel Cincinnati
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southwest Ohio Hotel Reviews

21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

10/10 Excellent
"Beautiful stay in 21C. The only thing that was unusual was the amount of time it took to be served Brunch on Sunday. They were severely understaffed. "
Ellen 1-night trip
Posted 5 days ago
21c Museum Hotel Cincinnati
The Cincinnatian Hotel Curio Collection by Hilton

The Cincinnatian Hotel Curio Collection by Hilton

10/10 Excellent
"Great proximity. The Valet stand was a bit disorganized, but when we got help, they did hustle to get our vehicle. Would appreciate if the valets would ask patrons to move out of the doorway-simple common sense, but seemed to be lacking. "
Jamie 2-night trip
Posted 8 days ago
The Cincinnatian Hotel Curio Collection by Hilton

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