Downtown South San Francisco, CA

San Francisco

Aerial View of a Local High School and an Athletic Field in a Neighborhood in South San Francisco, California, USA
Aerial view of the South San Francisco area
Aerial view of downtown San Francisco and Financial District sky scrapers flying over South San Francisco The Industrial City inscription on San Bruno mountain circa 2015

Popular places to visit

Things to do


Downtown South San Francisco Hotel Deals

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ¥17,735 per night from Apr 25 to Apr 26
¥17,735
¥20,789 total
Apr 25 - Apr 26
includes taxes & fees
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast ...
8.2/10 Very Good! (1,982 reviews)
It felt safe . Wish breakfast included yogurt and fruit.

Reviewed on Apr 10, 2026

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ¥20,984 per night from Apr 19 to Apr 20
¥20,984
¥24,697 total
Apr 19 - Apr 20
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
9/10 Wonderful! (5,549 reviews)
Beds were comfortable. I slept well. Staff were excellent. Restaurant misses the mark. Food is fine, dining area is very cafeteria like.

Reviewed on Apr 11, 2026

Holiday Inn Golden Gateway by IHG
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
The price is ¥24,341 per night from Apr 19 to Apr 20
¥24,341
¥28,649 total
Apr 19 - Apr 20
includes taxes & fees
Book a stay at this family-friendly hotel in San Francisco. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
8.8/10 Excellent! (2,995 reviews)
Great hotel, friendly staff, clean and tidy, in a great location, would recommend to anyone and would definitely stay there again.

Reviewed on Apr 11, 2026

Handlery Union Square Hotel
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is ¥22,140 per night from Apr 27 to Apr 28
¥22,140
¥32,620 total
Apr 27 - Apr 28
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (7,389 reviews)
The breakfast was great, especially when staying with children. Pool was good, even for the cold month of April.

Reviewed on Apr 11, 2026

Hotel Riu Plaza Fisherman's Wharf
YOTEL San Francisco

YOTEL San Francisco

3 out of 5
1095 Market St San Francisco CA
The price is ¥12,184 per night from Apr 13 to Apr 14
¥12,184
¥17,150 total
Apr 13 - Apr 14
includes taxes & fees
Stay at this hotel in San Francisco. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.2/10 Very Good! (1,011 reviews)
Decent coffee and baked goods at breakfast. For some reason, my room wasn't cleaned unless I asked specifically.

Reviewed on Apr 11, 2026

YOTEL San Francisco
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
The price is ¥18,902 per night from Apr 26 to Apr 27
¥18,902
¥22,247 total
Apr 26 - Apr 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9/10 Wonderful! (3,048 reviews)
Good staff at breakfast and it was a well located place that felt high quality

Reviewed on Apr 11, 2026

Club Quarters Hotel in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Downtown South San Francisco

Aerial View Of Urban Neighborhood

Noe Valley

5/5(1 area review)

Appreciated for its churches and architecture, you might consider exploring Noe Valley. Check out the variety of things to see and do like 22nd St Hill, and jump on the metro at Church St & Clipper St Stop or Church St & 24th St Stop to get around the city.

Noe Valley
Mission District

Mission District

3.5/5(141 area reviews)

Mission District is a destination travelers like for its bars, and you might hop aboard the metro at 16th Street Mission Station or 24th Street Mission Station to explore sights like SOMA Pilipinas.

Mission District
Sunset District

Sunset District

3.5/5(176 area reviews)

Travelers choose Sunset District for its pristine beaches. Hop aboard the metro at Judah Street & Sunset Boulevard Station or Judah St & 34th Ave Stop and check out top sights like Ocean Beach.

Sunset District
Outer Sunset

Outer Sunset

When in Outer Sunset and the surrounding area, you'll want to check out sights like Ocean Beach or San Francisco Botanical Garden and hop on the metro to see more the city at Judah St & 34th Ave Stop or Judah Street & Sunset Boulevard Station.

Outer Sunset
South of Market

South of Market

3.5/5(3,694 area reviews)

Oracle Park and San Francisco Bay are top sights in South of Market, and you should be sure to explore the popular shops. Hop aboard the metro at Yerba Buena-Moscone Station or Fourth-Brannan Station to see more sights in the area.

South of Market
Golden Gate

Golden Gate

While you're in Golden Gate, take in top sights like San Francisco Botanical Garden or Japanese Tea Garden, and hop on the metro to see more the city at Irving St & 9th Ave Stop or Irving St & 8th Ave Stop.

Golden Gate


Downtown South San Francisco, CA