A calm river with clear water, surrounded by dense trees and rocky banks.

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Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

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Our top choices for O Brien hotels

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

1. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,208 reviews)
"Very nice visit, very clean room, excellent staff, great breakfast, easy parking"
United States
Emory
The price is ￥14,834
￥16,688 total
includes taxes & fees
Dec 2 - Dec 3
La Quinta Inn & Suite by Wyndham Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.

2. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,134 reviews)
"Nice staff great rooms"
United States
Ashlee
The price is ￥12,658
￥14,240 total
includes taxes & fees
Dec 10 - Dec 11
Best Western Plus Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

3. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,002 reviews)
"Overall great stay!"
United States
Jim
The price is ￥14,930
￥16,796 total
includes taxes & fees
Dec 6 - Dec 7
Comfort Suites Lake City
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

4. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,004 reviews)
"Clean and well maintained hotel"
United States
Carlos
The price is ￥14,695
￥16,533 total
includes taxes & fees
Dec 6 - Dec 7
Tru by Hilton Lake City
A spacious indoor area with a pool view, multiple seating arrangements, and a central plant.

5. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,004 reviews)
"I have stayed here several times. Staff is at least very friendly and accommodating properties very clean. We enjoyed our stay."
United States
Eileen
The price is ￥15,856
￥17,837 total
includes taxes & fees
Dec 6 - Dec 7
Hampton Inn & Suites Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

6. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (300 reviews)
"Stayed here on the way to Disney so wouldn't have to drive so far one way for the family. It was a nice place to stay."
United States
Anthony
The price is ￥14,861
￥16,719 total
includes taxes & fees
Dec 4 - Dec 5
Fairfield Inn & Suites Lake City
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

7. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"This is a great hotel for the price. Clean, room was small. Close to restaurants and parking lot is well lite."
United States
Brenda
The price is ￥11,235
￥12,641 total
includes taxes & fees
Nov 30 - Dec 1
Americas Best Value Inn Lake City
A reception area with a counter, seating, and a fireplace.

8. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (900 reviews)
"Nice place"
United States
Andrew
The price is ￥16,591
￥18,250 total
includes taxes & fees
Dec 6 - Dec 7
Holiday Inn Express & Suites Live Oak by IHG
A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

9. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (315 reviews)
"Nice overnight stay."
United States
Zanza
The price is ￥18,345
￥20,638 total
includes taxes & fees
Nov 22 - Nov 23
Courtyard By Marriott Lake City
An outdoor patio area with wicker chairs, a round table, and a fire pit.

10. TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (152 reviews)
"Very clean! Comfy beds!"
United States
John
The price is ￥20,383
￥22,931 total
includes taxes & fees
Nov 22 - Nov 23
TownePlace Suites by Marriott Lake City
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

11. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (834 reviews)
"Big, clean room and the staff was very friendly"
United States
Laurie
The price is ￥18,753
￥21,096 total
includes taxes & fees
Nov 22 - Nov 23
Home2 Suites by Hilton Lake City
A spacious lobby with multiple seating areas, a bar, and a large window with a view.

12. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,004 reviews)
"Next time I am needing motel in Lake City, will plan to stay at this location."
United States
William
The price is ￥15,959
￥17,953 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn & Suites Lake City by IHG
A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

13. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (767 reviews)
"Complimentary dinner and cooked to order eggs at breakfast. Neat and clean. Comfy bed."
United States
Allan
The price is ￥9,670
￥10,878 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Lake City
A hotel room with two beds, a desk, a chair, a lamp, and a view of the outdoors.

14. Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
2.5 star property
Live Oak
7.0 out of 10, Good, (600 reviews)
"Everything good"
United States
Guillermo
The price is ￥13,210
￥14,531 total
includes taxes & fees
Nov 29 - Nov 30
Quality Inn & Suites Live Oak I-10 Exit 283
A bedroom with a bed, a desk, a chair, and a ceiling fan.

15. Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (142 reviews)
"It was a clean room. We could park outside our room door."
United States
Keith
The price is ￥13,808
￥14,921 total
includes taxes & fees
Dec 11 - Dec 12
Cindys Motel
A hotel room with two beds, a TV, a desk, and a painting of a sunset.

16. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,002 reviews)
"Nice breakfast."
United States
Nathan
The price is ￥10,610
￥11,937 total
includes taxes & fees
Dec 1 - Dec 2
Days Inn by Wyndham Lake City I-75
A wooden cabin with a porch, a front door, and a small window.

17. Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.6 out of 10, Excellent, (34 reviews)
"This is a lovely place to visit"
United States
Beth
The price is ￥14,221
￥19,065 total
includes taxes & fees
Nov 11 - Nov 12
Suwannee River Rendezvous
A hotel reception area with a reception desk, seating area, and a view of the parking lot.

18. Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (327 reviews)
"I definitely will not recommend anyone to book a room there. The rooms are in bad sharp. The whole hotel need remodel."
United States
Alexia
The price is ￥11,558
￥12,715 total
includes taxes & fees
Nov 18 - Nov 19
Econo Lodge Live Oak
A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

19. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (710 reviews)
"Great breakfast options quiet clean place to stay"
United States
Pennee
The price is ￥9,226
￥10,149 total
includes taxes & fees
Dec 6 - Dec 7
Quality Inn White Springs Suwanee
A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.

20. Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (623 reviews)
"This is the second time I’ve stayed at this hotel. Convenient to restaurants and gas stations. Look forward to staying again."
United States
Gerardo
The price is ￥9,803
￥11,029 total
includes taxes & fees
Nov 17 - Nov 18
Regal Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

8/10 Good
"No receipt sent to me"
Sandy 1-night trip
Posted 15 hours ago
Hampton Inn & Suites Lake City

More cheap stays in O Brien

Quality Inn Lake City

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL
The price is ￥10,864 per night from Dec 9 to Dec 10
￥10,864
￥12,221 total
Dec 9 - Dec 10
includes taxes & fees
8.2/10 Very Good! (1,000 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
What's the top vacation rental in O Brien?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors give good reviews to this O Brien vacation home rental, which is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Our travelers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favorite home for rent in O Brien. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Provides buffet, an indoor pool, and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

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