Find hotels in O Brien, FL from ¥10,154

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Our top choices for O Brien hotels

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (179)
Located near Lake City Mall and Regal UA Cinema 90, this hotel offers an outdoor pool and comfortable accommodations. Grab a bite at the café or unwind with a drink at the bar after a busy day exploring local attractions.

"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
The price is ¥16,686
¥18,771 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Courtyard By Marriott Lake City

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1014)
Enjoy a refreshing dip in the indoor pool after a day of exploration. This hotel offers complimentary breakfast, WiFi and parking. Located near Regal UA Cinema 90 and Lake City Mall, with attentive staff ready to enhance your stay.

"Fantastic stay 10/10"
United States
Michael
The price is ¥12,928
¥14,543 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Best Western Plus Lake City

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (169)
Unwind at this welcoming Lake City retreat where the indoor pool refreshes morning swimmers and the hot tub soothes evening relaxers. Free breakfast, WiFi and parking enhance your stay near Regal UA Cinema 90 and Lake City Mall.

"Very clean, friendly staff, safe and quiet "
United States
Amy
The price is ¥13,879
¥15,614 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Fairfield Inn & Suites Lake City

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.8 out of 10, Excellent, (1017)
Experience comfort at this hotel with a 24-hour fitness center and indoor pool. Near Regal UA Cinema 90 and Lake City Mall, guests praise the free breakfast and helpful staff. Enjoy free WiFi and parking during your stay.

"Very clean property and a full hot breakfast buffet! "
United States
Julie
The price is ¥14,615
¥16,442 total
includes taxes & fees
Dec 28 - Dec 29
La Quinta Inn & Suite by Wyndham Lake City

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1000)
Enjoy the outdoor pool and free breakfast at this welcoming Lake City hotel. Located close to Regal UA Cinema 90 and Lake City Mall, guests appreciate the helpful staff, fitness center, and convenient free parking and WiFi.

"Great staff"
United States
Alison
The price is ¥16,700
¥18,788 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Comfort Suites Lake City

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
Live Oak
7.2 out of 10, Good, (618)
Located close to Blue Sink Canoe Launch, this Live Oak hotel offers hiking trails and clean rooms with free WiFi. Enjoy the outdoor pool after exploring Stephen Foster Folk Culture Center State Park. Business travelers appreciate the friendly staff.

"Clean rooms, very friendly staff"
United States
Kristin L
The price is ¥10,604
¥11,665 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Quality Inn White Springs Suwanee

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (157)
Immerse yourself in natural beauty at this High Springs cabin. Each unit offers a kitchenette and private patio. Ruth B. Kirby Gilchrist Blue Springs State Park and Poe Springs Park are just moments away, with free parking on-site.

"Fantastic place! Very nice amenities and service was wonderful"
United States
Annette
The price is ¥15,458
¥30,745 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1001)
Experience comfort at this Alachua hotel featuring an outdoor pool and hot tub. Enjoy complimentary breakfast, WiFi, and parking while staying close to Alachua Sports Complex. Business-friendly accommodations include in-room refrigerators and microwaves, with a 24-hour fitness center for active travelers.

"Easy check in, friendly staff, hot tub, nice clean rooms. "
United States
Kelsey
The price is ¥18,268
¥20,552 total
includes taxes & fees
Dec 29 - Dec 30
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (475)
Located in Alachua, this welcoming hotel offers an outdoor pool and fitness center just minutes from the Sports Complex. Clean rooms and helpful staff create a relaxing atmosphere, while free parking adds convenience for business and leisure travelers alike.

"Staff very helpful- clean updated facility. "
United States
bethany
The price is ¥16,516
¥18,580 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1003)
Soak up Florida sunshine at the outdoor pool of this welcoming hotel. Located near Regal UA Cinema 90 and Lake City Mall, it offers free breakfast, WiFi, and parking. Clean rooms and helpful staff ensure a pleasant business or leisure stay.

"Clean room, staff, everyone super helpful ."
United States
Devang
The price is ¥18,112
¥20,376 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn & Suites Lake City

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.2 out of 10, Good, (665)
This motel offers complimentary cooked-to-order morning meals and convenient free parking. Located near North Florida Speedway and Southside Sports Complex, guests appreciate the attentive staff. Take advantage of the outdoor swimming area and free WiFi during your stay.

"It was clean, quiet, safe."
United States
donna
The price is ¥10,352
¥11,646 total
includes taxes & fees
Dec 28 - Dec 29
Super 8 by Wyndham Lake City

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1002)
Centrally located near Regal UA Cinema 90 and Lake City Mall, this hotel provides free breakfast, WiFi and parking. Take a refreshing dip in the outdoor pool or maintain your routine in the fitness center while enjoying exceptional staff service.

"Great place for a restful night when traveling. "
United States
Peggy
The price is ¥15,638
¥17,592 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Tru by Hilton Lake City

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
8.2 out of 10, Very Good, (83)
Located in Lake City with easy access to Regal UA Cinema 90 and Lake City Mall, this motel offers convenient amenities including complimentary WiFi, free parking, and 24-hour front desk service.

"Large room, comfortable bed, clean, pet friendly"
United States
D'Ann
The price is ¥9,554
¥10,748 total
includes taxes & fees
Dec 28 - Dec 29
Motel 6 – Lake City, Fl – Medical Center

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1000)
Enjoy a refreshing swim in the indoor pool before grabbing a bite at The Atrium restaurant. This hotel offers free WiFi, parking, and a 24-hour fitness center, all minutes from Regal UA Cinema 90 and Lake City Mall. Staff receives high marks from guests.

"Nice hotel but a little pricey "
United States
Hilary
The price is ¥14,814
¥16,667 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Holiday Inn & Suites Lake City by IHG

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.4 out of 10, Good, (581)
Escape to this peaceful hotel in Lake City with free WiFi and parking. The comfortable beds ensure a restful night, while the helpful staff enhance your stay. Nearby O'Leno State Park offers scenic outdoor adventures.

"Clean and nice staff "
United States
apollo
The price is ¥10,141
¥11,409 total
includes taxes & fees
Dec 28 - Dec 29
Palms Garden Inn

Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.6 out of 10, Exceptional, (13)
This serene retreat offers furnished balconies or patios overlooking Lake City's natural beauty. Enjoy complimentary WiFi and parking while exploring nearby O'Leno State Park and Hog Lake for outdoor adventures.

"This is my second time staying on this property and I love it "
United States
brandie
The price is ¥15,095
¥27,229 total
includes taxes & fees
Jan 20 - Jan 21, 2026
Vista Verde Farm Retreat

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1003)
Set yourself up for Florida exploration at this well-placed hotel with free breakfast and parking. Minutes from Lake City Mall and Regal UA Cinema 90, guests appreciate the clean rooms, helpful staff, and abundant dining options just outside.

"Staff was great"
United States
Thomas
The price is ¥9,868
¥11,100 total
includes taxes & fees
Dec 28 - Dec 29
Days Inn by Wyndham Lake City I-75

Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very Good, (775)
Located off the interstate, this hotel provides easy access to Suwannee County Historical Museum. Start mornings with free breakfast before exploring First Federal Sportsplex nearby. Clean rooms await after a workout in the fitness center.

"Have stayed here whenever we are in town. Always god stay."
United States
Gregg
The price is ¥18,830
¥20,715 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express & Suites Live Oak by IHG

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.8 out of 10, Excellent, (1000)
Unwind at this value-driven motel offering complimentary breakfast, WiFi, and parking. Take a swim in the outdoor pool after exploring nearby Regal UA Cinema 90 and Lake City Mall. Guests consistently praise the helpful staff and immaculate rooms.

"We had a good stay, the room was clean, check in quick and easy, the bed was comfortable."
United States
Alan
The price is ¥10,485
¥11,795 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Americas Best Value Inn Lake City

The Blanche

The Blanche
2.0 star property
Lake City
9.2 out of 10, Wonderful, (164)
This boutique hotel in Lake City offers comfortable rooms with premium bedding and in-room coffeemakers. Just moments from Columbia County Historical Museum and Lake DeSoto Farmers Market, guests enjoy complimentary WiFi throughout their stay.

"Easy to access building and room with code provided; amazing bed and very clean."
United States
Ruth
The Blanche
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

More cheap stays in O Brien

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Tru by Hilton Lake City. See all available top hotels, or vacation rentals in O Brien.
What's the top vacation rental in O Brien?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors like this O Brien vacation home rental. It is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Bob's River Place in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

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