Find hotels in O Brien, FL from ￥9,007

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 11 - Nov 12
Tomorrow
Nov 12 - Nov 13
This weekend
Nov 14 - Nov 16
Next weekend
Nov 21 - Nov 23

Filter by

Guest rating
Guest rating
Star rating

Compare 341 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
Alachua
9.4 out of 10, Exceptional, (1009)
"Room was very clean, staff friendly "
United States
Angela
The price is ￥19,577
￥22,024 total
includes taxes & fees
Nov 16 - Nov 17
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
Lake City
8.8 out of 10, Excellent, (1010)
"Check in was an extremely easy process with the pre-check in link. Friendly courteous staff. Room was clean and comfortable. Will definitely stay in the future "
United States
Sara
The price is ￥14,428
￥16,232 total
includes taxes & fees
Dec 1 - Dec 2
La Quinta Inn & Suite by Wyndham Lake City
Desk, blackout drapes, iron/ironing board, rollaway beds
Americas Best Value Inn Alachua

Americas Best Value Inn Alachua

2.0 star property
Alachua
4.8 out of 10, (594)
"Staff was helpful and so courteous.."
United States
Christian
The price is ￥8,803
￥9,903 total
includes taxes & fees
Nov 12 - Nov 13
Americas Best Value Inn Alachua
Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

2.5 star property
Alachua
9.4 out of 10, Exceptional, (465)
"We would definitely stay here again if we are ever in this area. "
United States
KAREN
The price is ￥15,219
￥17,121 total
includes taxes & fees
Nov 18 - Nov 19
Hampton Inn & Suites Alachua I-75
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1005)
"Clean room, friendly staff "
United States
Bill
The price is ￥12,486
￥14,047 total
includes taxes & fees
Dec 1 - Dec 2
Best Western Plus Lake City
Property amenity
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3.0 star property
Lake City
9.6 out of 10, Exceptional, (166)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
The price is ￥16,494
￥18,556 total
includes taxes & fees
Nov 23 - Nov 24
Courtyard By Marriott Lake City
Pillowtop beds, desk, laptop workspace, iron/ironing board
Comfort Suites Lake City

Comfort Suites Lake City

2.5 star property
Lake City
9.6 out of 10, Exceptional, (1003)
"Nice clean rooms "
United States
Bethany
The price is ￥14,282
￥16,068 total
includes taxes & fees
Nov 18 - Nov 19
Comfort Suites Lake City
Double Room, Non Smoking | Laptop workspace, free WiFi
High Springs Country Inn

High Springs Country Inn

2.0 star property
High Springs
8.6 out of 10, Excellent, (13)
"It was a comfortable stay for one night"
United States
Thomas
The price is ￥12,013
￥13,515 total
includes taxes & fees
Nov 13 - Nov 14
High Springs Country Inn
Standard Cabin, 1 Queen Bed | Exterior
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

2.0 star property
High Springs
9.8 out of 10, Exceptional, (134)
"Great place to getaway. "
United States
Carlyson Barros
The price is ￥16,802
￥25,266 total
includes taxes & fees
Nov 12 - Nov 13
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Standard Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee

2.5 star property
Live Oak
7.2 out of 10, Good, (603)
"The room was ok (not good, not bad, just ok). The breakfast was also ok. The room was a bit small for three people."
Canada
Sichao
The price is ￥9,311
￥10,242 total
includes taxes & fees
Nov 16 - Nov 17
Quality Inn White Springs Suwanee
Exterior
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1005)
"Good hotel"
United States
Frank
The price is ￥13,442
￥15,122 total
includes taxes & fees
Nov 30 - Dec 1
Tru by Hilton Lake City
Outdoor pool
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

2.5 star property
Lake City
5.0 out of 10, (1000)
"Friendly staff checked me in. Clean room "
United States
Jeffrey
The price is ￥8,910
￥10,025 total
includes taxes & fees
Nov 16 - Nov 17
Baymont by Wyndham Lake City I-75
Individually decorated, desk, laptop workspace, iron/ironing board
Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10

2.0 star property
Lake City
6.8 out of 10, (1001)
"Was quite and clean, a little dated but it was a good place to sleep they are pet friendly "
United States
William
The price is ￥9,249
￥10,405 total
includes taxes & fees
Nov 12 - Nov 13
Days Inn by Wyndham Lake City I-10
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

2.5 star property
Lake City
9.0 out of 10, Wonderful, (149)
"Yes great"
United States
Michael
The price is ￥15,035
￥16,915 total
includes taxes & fees
Nov 17 - Nov 18
Fairfield Inn & Suites Lake City
Outdoor pool, sun loungers
Quality Inn Lake City

Quality Inn Lake City

2.5 star property
Lake City
7.8 out of 10, Good, (944)
"Everything was great about this property and the staff were very friendly and accommodating. "
United States
Andrew
The price is ￥10,351
￥11,645 total
includes taxes & fees
Dec 10 - Dec 11
Quality Inn Lake City
BBQ/picnic area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

2.0 star property
Lake City
8.8 out of 10, Excellent, (1002)
"Great value, super polite staff, and clean, comfortable rooms"
United States
chelsea
The price is ￥10,351
￥11,645 total
includes taxes & fees
Nov 12 - Nov 13
Americas Best Value Inn Lake City
Reception
BlueGem Motel

BlueGem Motel

2.0 star property
High Springs
9.2 out of 10, Wonderful, (381)
"Great hotel"
United States
Wesley
The price is ￥15,815
￥17,792 total
includes taxes & fees
Nov 18 - Nov 19
BlueGem Motel
Lobby
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

2.0 star property
Lake City
8.4 out of 10, Very Good, (37)
"Great little motel with extremely nice staff. "
United States
Georgiy
The price is ￥8,007
￥9,007 total
includes taxes & fees
Nov 16 - Nov 17
Motel 6 – Lake City, Fl – Medical Center
Lobby
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

2.5 star property
Lake City
9.4 out of 10, Exceptional, (1000)
"It was a great stay "
United States
Miranda
The price is ￥13,992
￥15,741 total
includes taxes & fees
Nov 17 - Nov 18
Hampton Inn & Suites Lake City
Pillowtop beds, in-room safe, desk, blackout drapes
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

2.0 star property
Lake City
7.4 out of 10, Good, (1000)
"Very clean! Very friendly staff! "
United States
Marleis
The price is ￥10,613
￥11,940 total
includes taxes & fees
Dec 1 - Dec 2
Days Inn by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

10/10 Excellent
"Really friendly staff, good breakfast. They are doing renovations but it didn’t affect our overnight. Handy off of the hiway. "
Kelly 1-night trip
Posted 2 days ago
Hampton Inn & Suites Lake City

More cheap stays in O Brien

Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr, Lake City, FL
The price is ￥12,486 per night from Dec 1 to Dec 2
￥12,486
￥14,047 total
Dec 1 - Dec 2
includes taxes & fees
9/10 Wonderful! (1,001 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are La Quinta Inn & Suite by Wyndham Lake City and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG. See all available top hotels, or vacation rentals in O Brien.
What's the top vacation rental in O Brien?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors like this O Brien vacation home rental. It is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
Best Western Plus Lake City: Offers a snack bar/deli, an indoor pool, and buffet. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

Explore a world of travel with Expedia