Uptown - Upper Duval, FL

Key West

Key West Butterfly and Nature Conservatory featuring zoo animals, animals and flowers
Key West Butterfly and Nature Conservatory showing zoo animals, animals and flowers
South Beach which includes a beach and a coastal town as well as a large group of people
South Beach showing a beach, swimming and a luxury hotel or resort
Key West Butterfly and Nature Conservatory featuring signage

Popular places to visit

Southernmost Point featuring signage as well as a large group of people

Southernmost Point

4.5/5(3,182 reviews)

Snap a memorable photograph from the edge of North America at this monumental landmark.

Southernmost Point
South Beach featuring a sandy beach and general coastal views as well as a small group of people

South Beach

4/5(980 reviews)

The southernmost beach in the continental United States is a convenient sandy enclave, just minutes from the center of town.

South Beach
Key West Butterfly and Nature Conservatory showing animals, zoo animals and food

Key West Butterfly and Nature Conservatory

4.5/5(760 reviews)

With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.

Key West Butterfly and Nature Conservatory

Things to do

Aerial view of people snorkeling in Key West

Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast

￥7,317
per adult
92% of travellers recommend
Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
12 hours Day at Key West With Boat Tour and Snorkeling

Day trip to Paradise from Miami: Key West Tour with Snorkeling, Open bar

￥4,019
per adult
80% of travellers recommend
Day trip to Paradise from Miami: Key West Tour with Snorkeling, Open bar
Key West Parasailing Downtown

Bucket-List Parasailing In Downtown Key West - Highest & Longest Rides

￥11,711
per traveler
92% of travellers recommend
Bucket-List Parasailing In Downtown Key West - Highest & Longest Rides
Miami to Key West Day Trip with Activities

Miami to Key West Day Trip with Activity Options

￥5,713
per adult
82% of travellers recommend
Miami to Key West Day Trip with Activity Options
Commotion on the Ocean Sunset Sail

Key West Sunset Sail with Live Music, Drinks and Appetizers!

￥11,711
per adult
92% of travellers recommend
Key West Sunset Sail with Live Music, Drinks and Appetizers!
Family navigating the sea on the glass bottom boat in Key West

Key West Sunset Cruise & Glass Bottom Eco Tour

￥9,422
per adult
74% of travellers recommend
Key West Sunset Cruise & Glass Bottom Eco Tour
See all activities in Key West

Uptown - Upper Duval Hotel Deals

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street, Key West, FL
Fully refundable
The price is ￥25,935 per night from Oct 29 to Oct 30
￥25,935
per night
Oct 29 - Oct 30
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,775 reviews)
"We loved thi"

Reviewed on Oct 7, 2025

Southernmost Beach Resort and Guesthouses
Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street, Key West, FL
The price is ￥19,191 per night from Oct 16 to Oct 17
￥19,191
per night
Oct 16 - Oct 17
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,191 reviews)
"Super fun! Pool was great because it was hot. Onsite bar was very fun!!"

Reviewed on Oct 5, 2025

Southwinds Motel
The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only

3 out of 5
525 United Street, Key West, FL
The price is ￥14,717 per night from Oct 13 to Oct 14
￥14,717
per night
Oct 13 - Oct 14
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,166 reviews)
"Great facility. Beautiful rooms. Fantastic pools. Conveniently situated in Key West. Absolute recommendation…."

Reviewed on Oct 8, 2025

The Southernmost Inn - Adults Only
The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton

4 out of 5
1435 Simonton Street, Key West, FL
The price is ￥31,834 per night from Oct 12 to Oct 13
￥31,834
per night
Oct 12 - Oct 13
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.4/10 Very Good! (1,002 reviews)
"The receptionists were very friendly and helpful and 4 Marlins was food exquisite !"

Reviewed on Oct 3, 2025

The Reach Key West, Curio Collection by Hilton
Kona Kai Oasis

Kona Kai Oasis

3 out of 5
630 South Street, Key West, FL
Stay at this 3-star guesthouse in Key West. Enjoy free WiFi, free parking, and a garden. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (563 reviews)
"The pool could use an upgrade."

Reviewed on Oct 6, 2025

Get rates
Kona Kai Oasis
Santa Maria Suites

Santa Maria Suites

4 out of 5
1401 Simonton St, Key West, FL
The price is ￥44,927 per night from Oct 13 to Oct 14
￥44,927
per night
Oct 13 - Oct 14
Stay at this 4-star resort in Key West. Enjoy free WiFi, 2 outdoor pools, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,003 reviews)
"We loved our 2b2b. The kitchen was fully stocked with cookware and we were given muffins, chocolates and bottled water everyday. Enjoyed the happy hour at their beautiful pool. Staff was friendly and knowledgeable too. Would definitely go back."

Reviewed on Oct 6, 2025

Santa Maria Suites
See all 2,797 properties in Uptown - Upper Duval
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Uptown - Upper Duval

Key West Historic District

Old Town Key West

4.5/5(226 area reviews)

Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.

Old Town Key West
Key West featuring a marina, a coastal town and general coastal views

Downtown Key West

If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.

Downtown Key West
Harry S. Truman Little White House which includes a house and cycling

Bahama Village

5/5(38 area reviews)

Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.

Bahama Village
Clarence S. Higgs Memorial Beach Park which includes landscape views, tropical scenes and a sandy beach

Casa Marina

While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Key West AIDS Memorial.

Casa Marina
Audubon House and Tropical Gardens featuring a house

Key West Historic District

4.5/5(4,033 area reviews)

Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.

Key West Historic District
Great location for great pictures, very nice beach

White Street Gallery District

When in White Street Gallery District, you can plan a visit to Duval Street and Saint Mary Star of the Sea, some noteworthy sights in the nearby area.

White Street Gallery District

Uptown - Upper Duval, FL