The Best Luxury Hotels in Key Largo, FL from ￥20,505 in 2026

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Our top choices for Key Largo luxury hotels

Playa Largo Resort & Spa, Autograph Collection

Rock Harbor

Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.

￥74,888 total

includes taxes & fees

Jun 1 - Jun 2

Baker's Cay Resort Key Largo, Curio Collection by Hilton

Key Largo

Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.

￥58,880 total

includes taxes & fees

Jun 17 - Jun 18

3 restaurants; breakfast, lunch, and dinner served

Reefhouse Resort & Marina

Key Largo

￥45,606 total

includes taxes & fees

Jun 21 - Jun 22

Cheeca Lodge & Spa

Matecumbe

Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.

￥60,234 total

includes taxes & fees

Jun 14 - Jun 15

The Islands of Islamorada

Matecumbe

￥128,961 total

includes taxes & fees

Jun 2 - Jun 3

In-room safe, individually decorated, individually furnished

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Islamorada

Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.

￥60,224 total

includes taxes & fees

Jun 23 - Jun 24

Room, 1 King Bed with Sofa bed, Oceanfront (Alligator Reef, Lanai) | View from room

Amara Cay Resort

Matecumbe

Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.

￥48,250 total

includes taxes & fees

Jun 14 - Jun 15

Islander Resort

Matecumbe

Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.

￥49,706 total

includes taxes & fees

Jun 8 - Jun 9

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Top Key Largo Hotel Reviews

Amoray Dive Resort

10/10 Excellent

"Lo máximo, servicio excelente , desde q uno llega , hasta q se retira, un lugar muy tranquilo , limpio y organizado y muy acogedor, sería uno de los lugares que volvería a ir . Más q agradecido a todo el personal, gracias"

The Pelican Key Largo Cottages

4/10 Poor

"The grounds were very nice and the room was cute. However, Beware of the fact that the staff leaves at night, and does not return until after 7:30 the next morning. A circuit breaker was tripped in my room ,and i had to locate the breaker box and reset it to restore power to the room . There were after hour numbers to call however, the lady at the check-in desk told me that I would probably wake somebody up if I called after hours and that would anger them, so I avoided that . Lastly, a group of people came in and took over the whole beach property during the night, they were loud abusive, and I’m not even sure if they were staying at the hotel. Because there was no one at the hotel this could not be reported ,so I had to go into my room for the rest of the night to avoid these people. The room was very affordable, but obviously not having a night person on site kept the cost down ,not a good trade-off, I won’t be coming back."

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?

Known for its sunsets and boating, Key Largo also has some interesting things to see and do including Everglades National Park, so you may want to take in the local sights during your visit.

What's the best high-end place to stay in Key Largo?

Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 3 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.

When can I expect good weather in Key Largo?

Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.

What's there to see and do in Key Largo?

Take in some sights and attractions while you're in Key Largo by visiting Everglades National Park, Jimmy Johnson's Big Chill, and Jacob's Aquatic Center. If you have a little extra time during your trip, you might want to make a stop at Bluefin Rock Harbor Marina and John Pennekamp Coral Reef State Park.

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Change your mind

Treat yourself

Be picky

Check availability on Key Largo Luxury Hotels

Our top choices for Key Largo luxury hotels

Playa Largo Resort & Spa, Autograph Collection