A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

Find Luxury Hotels in Key Largo, FL

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Check availability on Key Largo Luxury Hotels

Tonight
Oct 12 - Oct 13
Tomorrow
Oct 13 - Oct 14
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Key Largo luxury hotels

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
¥41,636
¥55,569 total
includes taxes & fees
Nov 1 - Nov 2
Playa Largo Resort & Spa, Autograph Collection

2. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
¥34,670
¥45,337 total
includes taxes & fees
Oct 13 - Oct 14
Reefhouse Resort & Marina

3. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
¥20,757
¥34,929 total
includes taxes & fees
Oct 13 - Oct 14
Cheeca Lodge & Spa

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
¥76,027
¥95,778 total
includes taxes & fees
Oct 13 - Oct 14
The Islands of Islamorada
View all properties

Top Key Largo Hotel Reviews

The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

8/10 Good
"Friendly, helpful staff. Great views of the sunset in Key Largo. Cute room & facility."
Amanda 1-night trip
Posted 2 hours ago
The Pelican Key Largo Cottages
Reefhouse Resort & Marina

Reefhouse Resort & Marina

10/10 Excellent
"Room was spacious, tidy, kitchen had everything you needed. Absolutely wonderful"
Doreen 1-night trip
Posted 2 hours ago
Reefhouse Resort & Marina
Bayside Inn Key Largo

Bayside Inn Key Largo

8/10 Good
"I stay at the Bayside Inn once a year while doing landscape photography in the Keys. Two issues bother me and will have me looking for a different place to stay next year. One, rooms aren't cleaned unless the guest asks / I stayed 9 days and no one had the professional courtesy to ask if I needed fresh towels or cleaning / I emptied my own trash. New policy or not about entering rooms, at these prices the front desk should pro actively call / text guests about needs. The second issue has to do with an additional amenity fee that is charged, other than my room, I use nothing else. I've asked about this but have never gotten a clear answer."
William 9-night trip
Posted 22 hours ago
Bayside Inn Key Largo
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"This is one of our favorite places to stay in Key Largo! We always enjoy coming back. The location is perfect, close to everything, yet quiet and relaxing. The staff is always friendly, welcoming, and helpful, making our stay even more enjoyable. It’s a place we love and keep coming back to!"
Zulma 3-night trip
Posted 23 hours ago
Sunset Cove Beach Resort
Waterside Suites & Marina

Waterside Suites & Marina

10/10 Excellent
"It was a good value for the cost of the rental! It was comfortable and close to all of the restaurants and things that we like to do! We would definitely rent again!"
Christine 5-night trip
Posted 1 day ago
Waterside Suites & Marina
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"This was my second time in Playa Largo of many more to come. The property is beautiful and meticulously maintained. With plenty of amenities and food options I rarely leave the property. Very friendly staff from the front desk to the pool staff, everyone is friendly and welcoming. Would definitely recommend! Best resort in the Keys!"
Nadieska 2-night trip
Posted 2 days ago
Playa Largo Resort & Spa, Autograph Collection
Gilbert's Resort

Gilbert's Resort

10/10 Excellent
"It's great for fishing lovers."
Sueviant 1-night trip
Posted 5 days ago
Gilbert's Resort

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 4 restaurants and 3 bars, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Jacob's Aquatic Center, and Bluefin Rock Harbor Marina. If you have a little extra time during your trip, you might want to make a stop at John Pennekamp Coral Reef State Park and MarineLab Undersea Laboratory.

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