Photo by Geraldine Soh

Find hotels near Historic Main Street, St. Louis from ￥12,655

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Dec 30 - Dec 31
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Jan 2 - Jan 4
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Our top choices for Historic Main Street hotels

Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
1.8 km from Historic Main Street
9.6 out of 10, Exceptional, (1002)
"Staff and hotel were amazing"
United States
Allison
The price is ￥17,935
￥20,791 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Plaza Hotel St. Louis St. Charles
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District, 1 km from Historic Main Street
9.4 out of 10, Exceptional, (1006)
"Everything was great!"
United States
Rita
The price is ￥16,439
￥18,893 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Country Inn & Suites by Radisson, St. Charles Historic District
Lobby
Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
1.5 km from Historic Main Street
9.2 out of 10, Wonderful, (640)
"Huge room. Great breakfast. "
United States
David
The price is ￥16,893
￥20,365 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Hampton Inn & Suites St. Charles Old Town Area
Lobby
Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
2.1 km from Historic Main Street
8.8 out of 10, Excellent, (1012)
"Breakfast was excellent along with clean comfortable beds. "
United States
Scott
The price is ￥19,056
￥21,901 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Embassy Suites by Hilton St. Louis St. Charles
Lobby
Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO
2.5 star property
2.1 km from Historic Main Street
8.6 out of 10, Excellent, (775)
"Room was wonderful great location"
United States
Sandra
The price is ￥16,499
￥19,127 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Tru by Hilton St. Charles St. Louis, MO
Casino
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
1.4 km from Historic Main Street
8.4 out of 10, Very Good, (1011)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is ￥27,934
￥35,237 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Ameristar Casino Resort and Spa
Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
1.5 km from Historic Main Street
8.4 out of 10, Very Good, (1001)
"Nice staff at reception. "
United States
Denise
The price is ￥12,333
￥14,173 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Comfort Suites St Charles - St Louis
Front of property - evening/night
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
3 km from Historic Main Street
8.4 out of 10, Very Good, (2222)
"Fun place to stay"
Canada
James
The price is ￥18,247
￥23,558 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Hollywood Casino & Hotel St. Louis
Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave | Premium bedding, pillowtop beds, in-room safe, desk
Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
1.4 km from Historic Main Street
8.2 out of 10, Very Good, (1007)
"Clean room, great stay"
United States
Becky
The price is ￥14,274
￥16,550 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Best Western Plus The Charles Hotel
Front of property - evening/night
Holiday Inn St. Louis Arpt West-Earth City by IHG

Holiday Inn St. Louis Arpt West-Earth City by IHG

Holiday Inn St. Louis Arpt West-Earth City by IHG
3.5 star property
2.9 km from Historic Main Street
7.6 out of 10, Good, (1000)
"It’s near to the exit to the highway "
United States
Gabriel
The price is ￥11,542
￥13,271 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Holiday Inn St. Louis Arpt West-Earth City by IHG
Terrace/patio
Elimwood Hotel, a Ramada by Wyndham

Elimwood Hotel, a Ramada by Wyndham

Elimwood Hotel, a Ramada by Wyndham
3.0 star property
3.1 km from Historic Main Street
7.4 out of 10, Good, (1001)
"Everything was nice"
United States
Ronald
The price is ￥14,037
￥16,281 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Elimwood Hotel, a Ramada by Wyndham
Interior entrance
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
1.6 km from Historic Main Street
5.8 out of 10, (1004)
"Nice staff, respectful."
United States
LaurenRenee
The price is ￥10,916
￥12,655 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
10.6 km from Historic Main Street
9.4 out of 10, Exceptional, (2775)
"Very clean and will definitely stay there again next time!"
United States
Tonya
The price is ￥14,036
￥16,524 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Pear Tree Inn St. Louis Airport
Property amenity
Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
12 km from Historic Main Street
9.4 out of 10, Exceptional, (1002)
"Great hotel! Clean, friendly staff, wonderful amenities!"
United States
Susan
The price is ￥17,155
￥19,721 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Inn & Suites St. Louis St. Peters
Property amenity
Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
3.0 star property
15.1 km from Historic Main Street
9.6 out of 10, Exceptional, (199)
"Very clean and safe place, wonderful location "
United States
Ashley
The price is ￥29,478
￥34,485 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Residence Inn by Marriott St. Louis Chesterfield
Exterior
Fairfield Inn & Suites St Louis Westport

Fairfield Inn & Suites St Louis Westport

Fairfield Inn & Suites St Louis Westport
2.5 star property
9.5 km from Historic Main Street
9.2 out of 10, Wonderful, (812)
"Everything was great "
United States
Alan
The price is ￥19,078
￥22,129 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Fairfield Inn & Suites St Louis Westport
Exterior
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
15.8 km from Historic Main Street
9.6 out of 10, Exceptional, (1040)
"Absolutely amazing stay very nice play our family stays there every time very kid friendly"
United States
Matthew
The price is ￥20,275
￥23,516 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Plaza Hotel St. Louis Chesterfield
Breakfast, lunch, dinner served; American cuisine
Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
3.0 star property
15.9 km from Historic Main Street
9.6 out of 10, Exceptional, (1002)
"Wonderful staff, easy parking, nice breakfast, very comfortable room."
United States
Carole
The price is ￥19,184
￥22,252 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hyatt Place St. Louis/Chesterfield
Room, 2 Queen Beds, Accessible, Non Smoking (Mobility, Tub W/Grab Bars) | Desk, laptop workspace, iron/ironing board, free cribs/infant beds
Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport
2.5 star property
10.7 km from Historic Main Street
9.2 out of 10, Wonderful, (1506)
"Good transport to and from car rental, a plus "
United States
Ralph
The price is ￥16,837
￥19,824 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Wingate by Wyndham St. Louis Airport
Lobby
Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport
3.0 star property
11.3 km from Historic Main Street
9.2 out of 10, Wonderful, (1111)
"Clean room, nice staff, great happy hour and breakfast!"
United States
Jeannette
The price is ￥16,531
￥19,396 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Inn & Suites St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Historic Main Street Hotel Reviews

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent
"Marsha was so friendly and helpful at the front desk. The breakfast was amazing as always. Our room was very clean and comfortable. These are just some of the reasons we stay at Country Inn and Suites on every trip to St. Charles."
Cynthia 1-night trip
Posted 2 days ago
Country Inn & Suites by Radisson, St. Charles Historic District

Hotels near other Historic Main Street attractions

Lewis & Clark festival
Photo by HA
Open Photo by HA

Frontier Park

You can find out about the history of St. Charles with a visit to Frontier Park. Check out the shops and top-notch restaurants in this walkable area.
See properties
trestle on Katy Trail in Missouri over Auxvasse Creek near Mokane - 237 mile bike trail stretching across most of the state of Missouri converted from abandoned railroad

Katy Trail

4.6/5 (53 reviews)
You can take time to visit Katy Trail during your travels to St. Charles. Experience the acclaimed theater scene and great live music in this family-friendly area.
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Frequently asked questions

What's the area like around Historic Main Street?
Historic Main Street is located in St. Charles. This historic area is known for its array of dining options and major shopping area. If you're looking for a convenient place to stay, check out the 91 hotels and other accommodations you'll find within a mile.
Where is the best place to stay close to Historic Main Street?
Ameristar Casino Resort and Spa is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and a casino. It's located just a short 0.9 mi (1.4 km) from Historic Main Street. Other good options close by include Best Western Plus The Charles Hotel and Country Inn & Suites by Radisson, St. Charles Historic District.
How many hotels are there near Historic Main Street?
Expedia has 91 hotels and other accommodations within a mile from Historic Main Street.
If I need to cancel the hotel reservation for my stay near Historic Main Street, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the top deals on offer near Historic Main Street.
Where can I learn more about changing or cancelling my trip in the area near Historic Main Street?
For more information about rescheduling or cancelling your stay near Historic Main Street, click here.
What can I see and do near Historic Main Street?
Sights like First Missouri State Capitol Historic Site and Lewis & Clark Boathouse and Nature Center highlight some of the local culture. Create some family memories at Centene Community Ice Center and Kokomo Joe's Family Fun Center. At Hollywood Casino Amphitheatre, Missouri Artists on Main, and Historic Aircraft Restoration Museum, you'll experience some of the local culture.