A cityscape with a prominent modern skyscraper, historic buildings, and a well-maintained park with a jogging path.

Find hotels in Central Southwest, Houston

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Central Southwest hotels

A modern hotel room with a large bed, wooden flooring, a bedside telephone, and a mirror.

1. Blue Diamond Inn

Blue Diamond Inn
2.0 star property
Central Southwest
7.4 out of 10, Good, (13 reviews)
"The motel was okay. "
United States
George
The price is ￥11,687
￥13,675 total
includes taxes & fees
Nov 10 - Nov 11
Blue Diamond Inn
A neatly made bed with white linens, a wooden headboard, and a bedside table with a telephone.

2. Maxim III Motel

Maxim III Motel
2.5 star property
Central Southwest
7.8 out of 10, Good, (16 reviews)
"Clean and helpful staff good service"
United States
Deionthay
The price is ￥8,043
￥9,410 total
includes taxes & fees
Dec 7 - Dec 8
Maxim III Motel
A modern hotel room with a large bed, white bedding, a bedside phone, and a visible bathroom door.

3. Crystal Suites

Crystal Suites
2.0 star property
Central Southwest
6.4 out of 10, (122 reviews)
"Perfect for what we needed it for Enjoy our stay every time we go "
United States
Theresa
The price is ￥10,237
￥11,977 total
includes taxes & fees
Nov 8 - Nov 9
Crystal Suites
A kitchen with white cabinetry, a central island with stools, and a view of the backyard through a sliding door.

4. Sweet Home - Private BR in a Shared Home

Sweet Home - Private BR in a Shared Home
2.0 star property
Central Southwest
The price is ￥35,621
￥60,471 total
includes taxes & fees
Nov 8 - Nov 9
Sweet Home - Private BR in a Shared Home
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

5. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
6.1 km from Central Southwest
9.4 out of 10, Exceptional, (1,009 reviews)
"Great stay."
United States
Francisco
The price is ￥18,584
￥21,871 total
includes taxes & fees
Nov 16 - Nov 17
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A reception area with a wooden reception desk, two refrigerators, and clocks displaying different city names.

6. Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 8.4 km from Central Southwest
9.4 out of 10, Exceptional, (484 reviews)
"Happy to stayed there!"
United States
AYTUNC
The price is ￥12,757
￥14,926 total
includes taxes & fees
Nov 10 - Nov 11
Best Western Plus Pearland/Houston Medical Center Hotel
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

7. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 8 km from Central Southwest
9.2 out of 10, Wonderful, (2,725 reviews)
"Great place to stay"
United States
Joel
The price is ￥19,600
￥23,054 total
includes taxes & fees
Nov 26 - Nov 27
Hyatt Place Houston Medical Center
A spacious room with large windows, a red armchair, a small table, and a cabinet with decorative items.

8. Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 12.1 km from Central Southwest
9.2 out of 10, Wonderful, (277 reviews)
"This place is perfect for either couples or people lodging on their own. It has just about everything you need and the rooms are a pretty good size."
United States
Algie
The price is ￥9,607
￥11,240 total
includes taxes & fees
Nov 8 - Nov 9
Studio 6 Houston, TX – Pearland/Medical Center
A hotel lobby with a seating area, a reception desk, and a staircase.

9. Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
16.4 km from Central Southwest
8.8 out of 10, Excellent, (1,428 reviews)
"Great staff and breakfast."
United States
Perfecto
The price is ￥12,316
￥14,162 total
includes taxes & fees
Dec 6 - Dec 7
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

10. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
6.8 km from Central Southwest
8.8 out of 10, Excellent, (1,007 reviews)
"Great location."
United States
Sandra P
The price is ￥13,954
￥16,327 total
includes taxes & fees
Dec 2 - Dec 3
Comfort Suites Houston near Medical Center- NRG Stadium
A hotel pool area with a bar, seating, and a view of the building's exterior.

11. Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
3.0 star property
7.6 km from Central Southwest
8.8 out of 10, Excellent, (1,003 reviews)
"The hotel was conveniently located for walking to Rice University and the room was clean and comfortable."
United States
Reagan
The price is ￥16,158
￥19,101 total
includes taxes & fees
Nov 25 - Nov 26
Courtyard By Marriott Houston Medical Center Reliant Park
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

12. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 9.3 km from Central Southwest
8.6 out of 10, Excellent, (2,243 reviews)
"Wonderful place to stay if you are going to the Medical Center."
United States
Cynthia
The price is ￥13,119
￥15,531 total
includes taxes & fees
Nov 22 - Nov 23
Hilton Houston Plaza/Medical Center
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

13. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 8 km from Central Southwest
9.2 out of 10, Wonderful, (1,284 reviews)
"Nice place to stay, very clean"
United States
Chafae
The price is ￥19,600
￥23,054 total
includes taxes & fees
Nov 26 - Nov 27
Hyatt House Houston Medical Center
A hotel lobby with a grand chandelier, a reception desk, and a carpet with the hotel's name.

14. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 8.3 km from Central Southwest
9.0 out of 10, Wonderful, (3,818 reviews)
"Great hotel definitely would stay again."
United States
Michael
The price is ￥23,116
￥27,134 total
includes taxes & fees
Nov 22 - Nov 23
Blossom Hotel Houston, Curio Collection by Hilton
A Holiday Inn Express hotel with a central entrance, palm trees, and a clear sky.

15. Holiday Inn Express Hotel & Suites Pearland by IHG

Holiday Inn Express Hotel & Suites Pearland by IHG
2.5 star property
15.2 km from Central Southwest
8.8 out of 10, Excellent, (1,002 reviews)
"The staff was very helpful and nice. This location was also very clean and comfortable. The breakfast was a major plus with great selections. I will definitely stay here again."
United States
Sha-keen
The price is ￥14,855
￥17,258 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express Hotel & Suites Pearland by IHG
A modern hotel room with a large bed, bedside tables, a desk, and a chair.

16. Best Western Plus Sugar Land/Stafford

Best Western Plus Sugar Land/Stafford
2.5 star property
16.8 km from Central Southwest
9.0 out of 10, Wonderful, (1,030 reviews)
"Everything was great, we enjoyed the two days that we stayed."
United States
Arturo
The price is ￥12,818
￥14,741 total
includes taxes & fees
Nov 15 - Nov 16
Best Western Plus Sugar Land/Stafford
A modern interior with a vertical garden wall and a sign reading "ESPERANTO".

17. Hotel Ylem

Hotel Ylem
3.5 star property
7.2 km from Central Southwest
8.2 out of 10, Very good, (1,598 reviews)
"clean hotel, very nice I enjoyed my stay!"
United States
aundrea
The price is ￥10,994
￥13,651 total
includes taxes & fees
Nov 19 - Nov 20
Hotel Ylem
The exterior of the First Colony Mall with a bakery named The Cheesecake Factory.

18. Hilton Garden Inn Houston/Sugar Land

Hilton Garden Inn Houston/Sugar Land
3.0 star property
20.5 km from Central Southwest
8.6 out of 10, Excellent, (1,073 reviews)
"Great place to stay!!"
United States
Beltran
The price is ￥13,253
￥15,241 total
includes taxes & fees
Dec 6 - Dec 7
Hilton Garden Inn Houston/Sugar Land
A Hyatt Place hotel with a view of a lake and a bridge.

19. Hyatt Place Houston/Sugar Land

Hyatt Place Houston/Sugar Land
3.0 star property
18.8 km from Central Southwest
9.0 out of 10, Wonderful, (1,968 reviews)
"Nice hotel, close to restaurants and lake"
United States
gerardo
The price is ￥14,993
￥17,242 total
includes taxes & fees
Nov 22 - Nov 23
Hyatt Place Houston/Sugar Land
A dining area with multiple tables and chairs, a stone fireplace, and a large window.

20. Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 16.2 km from Central Southwest
8.8 out of 10, Excellent, (1,012 reviews)
"Great attentive staff, clean rooms"
United States
Brian
The price is ￥13,922
￥16,448 total
includes taxes & fees
Nov 26 - Nov 27
Doubletree by Hilton Houston Hobby Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Central Southwest

Find the best Central Southwest areas and neighborhoods for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top Central Southwest Hotel Reviews

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

10/10 Excellent
"Room was in excellent condition. This is where we stay each time we come to Houston."
Rita 1-night trip
Posted less than an hour ago
Hilton Houston Plaza/Medical Center

Frequently asked questions

What is Central Southwest like?
You'll be sure to have fun visiting Houston's Central Southwest neighborhood. Be sure to check out Wildcat Golf Club and Houston Sports Park as part of your Central Southwest travel plans.
What's a favorite place to stay in Central Southwest?
Expedia customers rank Cute And Cozy Hostel the highest for a stay in Central Southwest. Another favorite option in the neighborhood is Crystal Suites.
How many hotels are there in Central Southwest?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 74 Central Southwest hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Central Southwest, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view the best options available in Central Southwest.
Where can I learn more about changing or cancelling my trip to Central Southwest?
For more details about picking new dates or cancelling your trip to Central Southwest, go to https://www.expedia.com/service/.
What can I see and do in this Houston neighborhood?
Spend some time exploring the natural setting of Central Southwest with a visit to Houston Sports Park and Eclectic Menagerie Park. Wildcat Golf Club and Aveva Stadium are also a couple of places to visit in the neighborhood. A few places to visit in the area around Central Southwest include American Cowboy Museum, The Collective: Grand Ballroom, and Garibaldi Sport Arena. When you're sightseeing around the area, Reliant Stadium and NRG Arena are a couple of other sights to visit.