Find Business Hotels in Central San Diego, CA

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Central San Diego Business Hotels

This weekend
Next weekend

Top Central San Diego Business Hotels

Our top choices for Central San Diego business-friendly hotels

Ayres Lodge Alpine

3.0 star property
9.2 out of 10, Wonderful, (1019)
"Our stay was great nice clean place staff are very friendly will definitely stay again "
The price is ¥14,931
¥16,155 total
includes taxes & fees
Sep 28 - Sep 29
Ayres Lodge Alpine

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1549)
"Great resort!"
The price is ¥15,180
¥18,484 total
includes taxes & fees
Oct 1 - Oct 2
Sycuan Casino Resort

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1097)
"Very nice clean hotel "
The price is ¥20,132
¥22,184 total
includes taxes & fees
Oct 8 - Oct 9
Ayres Hotel San Diego South - Chula Vista

Legacy Resort Hotel & Spa

4.0 star property
9.2 out of 10, Wonderful, (2891)
"Great stay overall"
The price is ¥23,137
¥26,595 total
includes taxes & fees
Sep 28 - Sep 29
Legacy Resort Hotel & Spa

Lafayette Hotel & Club

4.0 star property
9.2 out of 10, Wonderful, (1166)
"Amazing, celebrated my birthday here with girlfriends and it was everything and more!"
The price is ¥33,360
¥38,281 total
includes taxes & fees
Sep 29 - Sep 30
Lafayette Hotel & Club

Hilton Garden Inn San Diego Mission Valley Stadium

3.0 star property
8.0 out of 10, Very Good, (1015)
"The stay was nice, breakfast is very good. Rooms are comfortable and clean. "
The price is ¥18,035
¥20,731 total
includes taxes & fees
Sep 29 - Sep 30
Hilton Garden Inn San Diego Mission Valley Stadium

Best Western Seven Seas

3.0 star property
7.8 out of 10, Good, (2967)
"Very nice property, Clean and friendly staff… Nice rooms amazing shower and excellent location"
The price is ¥12,480
¥14,346 total
includes taxes & fees
Sep 28 - Sep 29
Best Western Seven Seas

Ramada Suites by Wyndham San Diego/Hotel Circle Area

2.5 star property
6.2 out of 10, (1005)
"great stay. Clean, quiet and convenient "
The price is ¥9,853
¥11,326 total
includes taxes & fees
Sep 28 - Sep 29
Ramada Suites by Wyndham San Diego/Hotel Circle Area

Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG

2.5 star property
8.8 out of 10, Excellent, (1006)
"Stylish hotel. "
The price is ¥19,495
¥22,409 total
includes taxes & fees
Oct 20 - Oct 21
Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG

Handlery Hotel

3.5 star property
8.2 out of 10, Very Good, (2112)
"Very nice stay"
Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Central San Diego Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Why book your business-friendly hotel in Central San Diego with Expedia?
Expedia will help you find the ideal business-friendly hotel for your upcoming work trip. From meeting rooms and conference spaces to on-site restaurants and more, our accommodations have all you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Central San Diego?
Click on the "business friendly" filter, located under the "traveler experience" heading, to find cheap business-friendly hotels in Central San Diego. Then fine-tune your search by your nightly budget. Looking for properties away from the center can also help you save.