Photo by Alice Burghart

Find Casinos in Cape Girardeau, MO

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Cape Girardeau Casinos

Our top choices for Cape Girardeau hotels with a casino

Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (469)
"Place was nice and safe"
United States
ryan
The price is ￥13,948
￥15,735 total
includes taxes & fees
Dec 16 - Dec 17
The Riverview
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is ￥18,066
￥20,472 total
includes taxes & fees
Dec 21 - Dec 22
Courtyard by Marriott Cape Girardeau Downtown
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is ￥22,235
￥25,084 total
includes taxes & fees
Dec 18 - Dec 19
Rockwood Inn
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is ￥23,361
￥38,149 total
includes taxes & fees
Dec 14 - Dec 15
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
The price is ￥41,910
￥68,148 total
includes taxes & fees
Dec 15 - Dec 16
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (662)
"Great place "
United States
GUY
The price is ￥13,106
￥14,185 total
includes taxes & fees
Jan 7 - Jan 8, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Smart TV, fireplace, DVD player
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (403)
"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."
United States
Tommy
The price is ￥18,222
￥31,527 total
includes taxes & fees
Dec 14 - Dec 15
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Exterior
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (60)
"The property was extremely clean and well cared for.would definitely stay again. "
United States
Dan H.
The price is ￥14,640
￥28,356 total
includes taxes & fees
Dec 15 - Dec 16
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Exterior
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.6 out of 10, Exceptional, (39)
"The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again."
United States
Victoria H.
The price is ￥16,976
￥33,173 total
includes taxes & fees
Dec 15 - Dec 16
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Exterior
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.
Makanda
9.6 out of 10, Exceptional, (41)
"Wonderful. Great location, close to wineries, Shawnee National Forest, and Giant City State Park and Lodge. Steve was great to work with. Will definitely stay again!!!"
United States
Allan T.
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Very friendly staff and great breakfast"
Ray 1-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau

Explore a world of travel with Expedia

Frequently asked questions

Searching for casino hotels in Cape Girardeau?
Hoping to win big in Cape Girardeau? You're in luck, because you'll find Isle Casino Cape Girardeau here, not to mention lots more to see and do. Visitors enjoy the riverfront, shopping, and dining options.
What's the best hotel for casino gaming in Cape Girardeau?
The Riverview is a top hotel featuring a casino and free WiFi.
How many hotels that are good for gaming can I expect to find in Cape Girardeau?
Hit the casinos and have a good night's sleep at one of Expedia's 57 casino hotels in Cape Girardeau.
When should I take my casino trip to Cape Girardeau?
You might spend a lot of your vacation inside, but if you're planning to venture beyond the casino, taking a look at local weather data can help you. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What is there to do in Cape Girardeau?
Cape Girardeau is known for its historic sites, offering you opportunities to enjoy the local culture. Some attractions to visit in the area are Cape Girardeau Conservation Nature Center and Lazy L Safari Park. For more to see and do, you can plan to visit Show Me Center and Cape Splash Family Aquatic Center.
What are my transportation options for my casino getaway to Cape Girardeau?
Here are some transportation options in Cape Girardeau: You can arrange a flight to the closest airport, which is Cape Girardeau, MO (CGI-Cape Girardeau Municipal), situated 6 mi (9.7 km) from the city center. If you'd like to explore around the area, you may want to rent a car for your trip.