Find 5 Star Hotels in Destin, FL from ￥20,818

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Destin 5 Star Hotels

Compare Destin 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
The Henderson Beach Resort & Spa

The Henderson Beach Resort & Spa

5.0 star property
Crystal Beach
9.2 out of 10, Wonderful, (1003)
"Beautiful hotel"
United States
stefanie
The price is ￥43,068
￥57,161 total
includes taxes & fees
Nov 16 - Nov 17
The Henderson Beach Resort & Spa
Beach
The Blue Pearl

The Blue Pearl

5.0 star property
Miramar Beach
The Blue Pearl
House, 6 Bedrooms, Ocean View, Beachfront | Balcony
Capitano 7 Bedroom Holiday Home by Five Star Properties

Capitano 7 Bedroom Holiday Home by Five Star Properties

5.0 star property
Destin
Capitano 7 Bedroom Holiday Home by Five Star Properties
House, 6 Bedrooms, Ocean View, Sea Facing | Aerial view
Stranded on a Sandbar 8 Bedroom Holiday Home by Five Star Properties

Stranded on a Sandbar 8 Bedroom Holiday Home by Five Star Properties

5.0 star property
Frangista Beach
Stranded on a Sandbar 8 Bedroom Holiday Home by Five Star Properties
House, 6 Bedrooms, Ocean View, Beachfront | Staircase
Millenia 7 Bedroom Holiday Home by Five Star Properties

Millenia 7 Bedroom Holiday Home by Five Star Properties

5.0 star property
Destin
Millenia 7 Bedroom Holiday Home by Five Star Properties
House, 4 Bedrooms, Ocean View, Sea Facing | BBQ/picnic area
Vista del Mare 4 Bedroom Holiday Home by Five Star Properties

Vista del Mare 4 Bedroom Holiday Home by Five Star Properties

5.0 star property
Destin
Vista del Mare 4 Bedroom Holiday Home by Five Star Properties
House, 6 Bedrooms, Ocean View, Beachfront | Outdoor pool
Palazzo del Mar 11 Bedroom Holiday Home by Five Star Properties

Palazzo del Mar 11 Bedroom Holiday Home by Five Star Properties

5.0 star property
Crystal Beach
Palazzo del Mar 11 Bedroom Holiday Home by Five Star Properties
House, Multiple Beds | Balcony
Palazzo del Mar by Five Star Properties

Palazzo del Mar by Five Star Properties

5.0 star property
Crystal Beach
Palazzo del Mar by Five Star Properties
House, 4 Bedrooms | Pool | Outdoor pool
Casa Esmeralda by Five Star Properties

Casa Esmeralda by Five Star Properties

5.0 star property
Destin
Casa Esmeralda by Five Star Properties
House, 5 Bedrooms, Ocean View, Sea Facing | Front of property - evening/night
Casa de Palms 5 Bedroom Holiday Home by Five Star Properties

Casa de Palms 5 Bedroom Holiday Home by Five Star Properties

5.0 star property
Avalon Beach Estates
Casa de Palms 5 Bedroom Holiday Home by Five Star Properties
House, 5 Bedrooms | 5 bedrooms, individually decorated, individually furnished, free WiFi
Modern Paradise by Five Star Properties

Modern Paradise by Five Star Properties

5.0 star property
Destin
Modern Paradise by Five Star Properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Destin.
The Island Resort at Fort Walton Beach

The Island Resort at Fort Walton Beach

Miracle Strip Parkway Southeast, 1500, Fort Walton Beach, FL
The price is ￥13,670 per night from Nov 16 to Nov 17
￥13,670
￥20,818 total
Nov 16 - Nov 17
includes taxes & fees
8.2/10 Very Good! (2,903 reviews)
Still don't see what you're looking for?
See all properties in Destin.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Destin

Sugar-white beaches and emerald waters make this Gulf Coast paradise perfect for snorkeling, dolphin cruises, and fresh seafood dining. Venture beyond the sand to explore Henderson Beach State Park's nature trails or book a deep-sea fishing charter where captains know exactly where the big ones hide.

See all hotels in Destin
Destin Florida Miramar beach

Top Destin Hotel Reviews

The Henderson Beach Resort & Spa

The Henderson Beach Resort & Spa

10/10 Excellent
"Everything was excellent!"
Rayme 5-night trip
Posted 2 days ago
The Henderson Beach Resort & Spa

Frequently asked questions

What are the best 5-star hotels in Destin?
Step into a world of indulgence at The Henderson Beach Resort & Spa. This is among the most highly rated 5-star hotels in Destin based on reviews by Expedia guests. From its guest services to its well-appointed rooms and prime location, you can rely on an exceptional guest experience.
How much does it cost to stay in a 5-star hotel in Destin?
How much you pay for a 5-star hotel in Destin can vary based on when you prefer to travel and how long you plan to stay, among other factors. Use our price per night filter and other search tools to find the best rate on a high-end getaway.

  • Search for the lowest price per night from ￥20,818

What makes a hotel 5 stars in Destin?
From gourmet restaurants and 24-hour fitness centers to pools and superior bedding, the 5-star experience in Destin is all about luxury and relaxation. But it takes more than just top-notch amenities to get a 5-star rating. Hotels must also provide superior guest services like in-room massage treatments, on-site laundry and 24-hour concierge services.

Explore a world of travel with Expedia