Find 4 Star Hotels in Upstate South Carolina, SC from ￥16,645

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
Mar 30 - Mar 31
Tomorrow
Mar 31 - Apr 1
This weekend
Apr 3 - Apr 5
Next weekend
Apr 10 - Apr 12

Our top choices for Upstate South Carolina 4-star hotels

Exterior

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (467 reviews)
"Beautiful and comfortable! We loved it and wish we could have stayed longer than one night!"
United States
Nancy
The price is ￥54,345
￥61,409 total
includes taxes & fees
Apr 2 - Apr 3
Grand Bohemian Lodge Greenville, Autograph Collection
Restaurant

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (685 reviews)
"Great place"
United States
Helen
The price is ￥25,698
￥33,686 total
includes taxes & fees
Apr 5 - Apr 6
Hotel Hartness
Lobby

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (778 reviews)
"Excellent stay, I highly recommend! Accommodations, location, overall vibe, great food and drinks! "
United States
Julie
The price is ￥32,306
￥35,860 total
includes taxes & fees
Apr 6 - Apr 7
The Shepherd Hotel Downtown Clemson
Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (807 reviews)
"Room was very roomy with plenty of extra linens. Very accessible to shopping and restaurants."
United States
Jill
The price is ￥15,132
￥16,645 total
includes taxes & fees
Apr 27 - Apr 28
Mint House Greenville Downtown by Kasa
Exterior

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,001 reviews)
"Great hotel Great location Great room Friendly and courteous staff"
United States
Charles
The price is ￥30,299
￥33,329 total
includes taxes & fees
Apr 5 - Apr 6
The Westin Poinsett Greenville
Bar (on property)

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (636 reviews)
"The airport shuttle arrived within 10 minutes of dispatch and the hotel and restaurant staff were very friendly and accommodating. "
United States
Leslie
The price is ￥18,941
￥21,523 total
includes taxes & fees
Apr 5 - Apr 6
Greenville Marriott
Lobby lounge

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (582 reviews)
"Great staff who demonstrates true southern hospitality. Five minute walk to campus and 10 minutes to downtown - could not be me more convenient. Also cozy bar allowed us to relax after a long day on the road. Nice to see them hiring Clemson students as my daughter who was there for a college tour got some great insights on life at Clemson."
United States
Walter
The price is ￥25,051
￥27,808 total
includes taxes & fees
Apr 13 - Apr 14
The Abernathy of Clemson
Trailside Wedge Cottage | Terrace/patio

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (18 reviews)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is ￥30,171
￥46,414 total
includes taxes & fees
Apr 5 - Apr 6
The Station by Compo Hotels
Front of property

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (86 reviews)
"The was by far one of the best bed and breakfast places that I have ever stayed in. The house is beautiful, the rooms and spotless and the breakfast is amazing. "
United States
Jennifer Ann
The price is ￥21,676
￥24,059 total
includes taxes & fees
Apr 16 - Apr 17
Liberty Hall Bed and Breakfast
Courtyard

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (33 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is ￥76,788
￥84,467 total
includes taxes & fees
Apr 2 - Apr 3
Hotel Domestique
Lobby

Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
4.0 star property
Greer
Landing Apartments Greer - Sugar Creek
Apartment, 2 Bedrooms | Living area | 50-inch TV with digital channels

Landing Apartments - Lyman

Landing Apartments - Lyman
4.0 star property
Lyman
Landing Apartments - Lyman
Apartment (2 Bedrooms) | Interior

Luxe Keowee Key Living: Golf Views & Resort Pool

Luxe Keowee Key Living: Golf Views & Resort Pool
4.0 star property
Salem
Luxe Keowee Key Living: Golf Views & Resort Pool
Apartment, 1 Bedroom | Private kitchen | Full-size fridge, microwave, oven, stovetop

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (46 reviews)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Apartment (2 Bedrooms) | Interior

Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
Lake Keowee Condo: Resort Pools & Lake Access!
Signature House, 4 Bedrooms, Patio | In-room dining

Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson
4.0 star property
Anderson
The price is ￥19,718
￥48,576 total
includes taxes & fees
Apr 1 - Apr 2
Lake Hartwell Frank Howard Home Clemson
Apartment (2 Bedrooms) | Interior

Clemson Game Retreat: Lakefront Keowee Key Condo

Clemson Game Retreat: Lakefront Keowee Key Condo
4.0 star property
Salem
Clemson Game Retreat: Lakefront Keowee Key Condo
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Frankie's Fun Park to The Shops at Greenridge.

See all hotels in Upstate South Carolina
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

Hotel Hartness

10/10 Excellent
"Nice property"
Kenneth 2-night trip
Posted 2 days ago
Hotel Hartness

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from ￥16,645

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

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