Top Cheap Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

7.8/10 Good! (1,005 reviews)

"Good"

Reviewed on Jul 16, 2025

Pear Tree Inn Sikeston

2602 E Malone Avenue, Sikeston, MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,001 reviews)

"Would have appreciated a way to charge our phone. We had our cord but nowhere to put it. Maybe a clock with the port for charging? The faucet leaked in the sink. Everything else was great."

Reviewed on Jul 15, 2025

Super 8 by Wyndham Farmington

930 Valley Creek Dr, Farmington, MO

2 hours drive from Mark Twain National Forest

Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

8/10 Very Good! (567 reviews)

Good place to stay.

"I stayed while recovering from knee replacement surgery. The staff was very friendly and accommodating. The housekeeping crew was fast, efficient, sweet, and went out of their way to be helpful. I was impressed with the cleanliness. Additionally, the walls must be well insulated because I did not ..."

Reviewed on Jul 17, 2025

See all 587 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.