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Top Adventure Southeast Missouri Hotels

Hampton Inn Farmington

850 Valley Creek Dr Farmington MO

2 hours drive from Mark Twain National Forest

Stay at this hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.8/10 Excellent! (534 reviews)

Property claimed to have a hot tub months prior at the time of booking. Definitely didn’t have a hot tub. The hot tub was the deciding factor of the booking.

Reviewed on Mar 8, 2026

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd Farmington MO

2 hours drive from Mark Twain National Forest

Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

9/10 Wonderful! (592 reviews)

Easy parking, quiet hotel, and comfortable bed.

Reviewed on Mar 7, 2026

Echo Bluff State Park

34489 Echo Bluff Dr Eminence MO

43 min drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Eminence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Echo Bluff State Park and ...

9.4/10 Exceptional! (229 reviews)

Asked to switch to a overview room and the were able to accommodate me with no problem.

Reviewed on Mar 11, 2026

See all 624 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.