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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Duval Street

Book a stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...

9.2/10 Wonderful! (1,317 reviews)

Travelers like: full-service spa, sauna, steam room, massage

Travelers say...

We had a wonderful stay at this hotel beautiful scenery, excellent staff and wonderful food. Everyone was so welcoming. The amenities were my favorite. We took the bikes and went for a long ride, played tennis swam and drink by the pool.

Reviewed on Apr 19, 2026

Pier House Resort & Spa

1 Duval St Key West FL

11 min walk from Duval Street

Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...

9/10 Wonderful! (1,085 reviews)

Travelers like: full-service spa, massage, facials, manicures and pedicures

Travelers say...

It is a great place for both kids and adults or even just a couple looking for romantic getaway. There's plenty of good food at the bar but one Duvall is not great for kids. It's better for adults and a nice night out. Staff is great. The rooms have beautiful views and having a private beach is an ...

Reviewed on Apr 19, 2026

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL

10 min walk from Duval Street

Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...

8.8/10 Excellent! (3,220 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...

Very nice property, great location, right near the beach(which is rare in Key West). Our only issue was the housekeeping services. We took the privacy sign off the door and were expecting to get the room cleaned while we were gone for the whole morning. Usually, thats when the cleaning is done. We ...

Reviewed on Apr 19, 2026

See all 8,282 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.