Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Ortygia Hotels

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Passeggio Adorno 10/12 Syracuse SR

12 min walk from Lungomare di Ortigia

Grand Hotel Des Ètrangers - The Leading Hotels of the World delivers luxe lodging where you'll enjoy designer toiletries and more. The spa, outdoor pool, and ...

9.4/10 Exceptional! (85 reviews)

"Excellent hotel and all staff were very friendly and helpful. We loved the pool."

Reviewed on Jun 12, 2026

Grand Hotel Ortigia Siracusa

Viale Mazzini, 12 Syracuse SR

6 min walk from Lungomare di Ortigia

Grand Hotel Ortigia Siracusa is one of the Syracuse luxury 5-star beach properties where you can treat yourself to Champagne service, plush bedding, and more. ...

9/10 Wonderful! (598 reviews)

"The mattress was hard. But overall great area and some very good restaurants around."

Reviewed on Jun 18, 2026

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR

6 min walk from Lungomare di Ortigia

Treat yourself to a luxury stay at Algila' Ortigia Charme Hotel, where you can enjoy amenities like 24-hour room service, rainfall showers, and more. Deluxe ...

9.6/10 Exceptional! (972 reviews)

"We were encouraged by a tour guide to book a multi-star resort hotel in the Center of Siracusa. But, our research persuaded us that a boutique hotel on the Island of Ortigia was more in line with our standards and preferences. The Algila Ortigia Charme Hotel both met and exceeded our expectations. ..."

Reviewed on Jun 12, 2026

See all 814 properties in Ortygia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.