Find hotels in Santa Lucia, Syracuse from ￥6,084

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Our top choices for Santa Lucia hotels

A historic building with a grand entrance, multiple flags, and a staircase leading to the entrance.

1. Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (717 reviews)
"We enjoyed our stay"
United States
Anna
The price is ￥13,557
￥15,455 total
includes taxes & fees
Nov 30 - Dec 1
Grande Albergo Alfeo
A multi-story building with a rooftop terrace, balconies, and a street view.

2. Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (302 reviews)
"Kind and attentive staff. Beautiful property."
United States
Rene
The price is ￥20,395
￥24,202 total
includes taxes & fees
Nov 20 - Nov 21
Caportigia Boutique Hotel
A building facade with a classical architectural style, featuring a large arched window with blue curtains, a decorative balcony railing, and intricate stone carvings.

3. Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (303 reviews)
"Very good situation between Ortigia and Syracuse, no car needed. Modern and clean."
Canada
Evelyne
The price is ￥8,423
￥9,603 total
includes taxes & fees
Dec 12 - Dec 13
Nostos rooms & Apartments
A hotel room with a large bed, a chair, a small table, and a chandelier.

4. Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (54 reviews)
"Location was very good"
United States
Jose
The price is ￥12,311
￥14,035 total
includes taxes & fees
Nov 16 - Nov 17
Hotel Palazzo Cavalieri
A balcony with a wicker chair and table, overlooking a marina with boats and buildings.

5. Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (45 reviews)
"Beautiful accomodation, perfect location close to restauranys and attractions, clean room/all renovated with style, friendly personnel, nice view of the port"
Canada
Martine
The price is ￥29,079
￥33,149 total
includes taxes & fees
Nov 16 - Nov 17
Fortaleza Charme House
A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.

6. Lakkios

Lakkios
3.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (84 reviews)
"The location of this place is amazing and that balcony view iconic. Staff super helpful too."
Canada
Marsel
The price is ￥14,454
￥16,478 total
includes taxes & fees
Nov 16 - Nov 17
Lakkios
A balcony with a table set for two, a chair, and a view of a building with multiple windows and balconies.

7. B&B Nike

B&B Nike
Santa Lucia
8.8 out of 10, Excellent, (95 reviews)
"The room and bathroom were large and clean. The mattress and sheets were fantastic. The room had air conditioning. The host was there at check in and was easily accessible. The location was great- just outside Ortigia. Parking was easy and close. An overall nice place to stay."
Canada
Chris
The price is ￥12,045
￥13,732 total
includes taxes & fees
Nov 16 - Nov 17
B&B Nike
A reception desk with a marble counter, a potted plant, and a framed picture.

8. Melody rooms

Melody rooms
Santa Lucia
9.0 out of 10, Wonderful, (2 reviews)
"Custo benefícios muito bom e localização boa. Sinal do wifi fraco no quarto q estávamos e café da manha com poucas opções."
Brazil
Phillipe
The price is ￥6,084
￥6,936 total
includes taxes & fees
Nov 28 - Nov 29
Melody rooms
A balcony with a view of the sea, a dining area with chairs, and a potted plant.

9. Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (134 reviews)
"We had an amazing time. Sabrina and Claudia were wonderful. The place is top notch in everything they do. The food was so fresh and delicious . I was sad when i had to leave them. High praise for this hotel. The views breath taking."
United States
Duane
The price is ￥31,883
￥36,838 total
includes taxes & fees
Nov 28 - Nov 29
Giuggiulena Villa
A hallway with framed artwork on the walls, a table with a candle and decorative items, and a person walking towards a door with a suitcase.

10. San Nicola Rooms Siracusa

San Nicola Rooms Siracusa
Santa Lucia
8.8 out of 10, Excellent, (16 reviews)
"The breakfast was great! The hosts were super friendly and helpful!"
United States
Lin
The price is ￥16,651
￥18,982 total
includes taxes & fees
Nov 14 - Nov 15
San Nicola Rooms Siracusa
A hotel room with a bed, a desk with a coffee machine, a TV, and a view of the beach.

11. Casa Miranda Boutique

Casa Miranda Boutique
Santa Lucia
8.8 out of 10, Excellent, (3 reviews)
"This was one of the best hotel stays I’ve ever had. Simply, you won’t be disappointed from location, excellent service and the most helpful and welcoming staffs. Highly recommended"
United States
Hossein
The price is ￥33,098
￥38,174 total
includes taxes & fees
Dec 14 - Dec 15
Casa Miranda Boutique
A marina with numerous boats docked, a clear sky, and a building with outdoor seating.

12. Regina Margherita

Regina Margherita
Santa Lucia
7.8 out of 10, Good, (22 reviews)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
The price is ￥7,921
￥9,029 total
includes taxes & fees
Nov 15 - Nov 16
Regina Margherita
An open balcony with a table and chairs, potted plants, and a view of a building with balconies and windows.

13. Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
9.8 out of 10, Exceptional, (19 reviews)
"The B&B owner Anna was really friendly and helpful. The hotel was centrally located, a few minutes walk from Ortigia. The room was spacious and really clean!"
Finland
Petri
The price is ￥20,033
￥22,838 total
includes taxes & fees
Nov 16 - Nov 17
Calafatari B&B
A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.

14. Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (46 reviews)
"Nice kitchen area, centrally located."
United States
Richard
The price is ￥8,012
￥9,134 total
includes taxes & fees
Nov 16 - Nov 17
Gymnasium
An outdoor café with tables and chairs, a bar sign, and a restaurant sign.

15. Residence Agatocle

Residence Agatocle
Santa Lucia
8.6 out of 10, Excellent, (10 reviews)
"I rented the whole apartment, so I do everything. There is full kitchen and wash machine. I could wash my laundry and keep everything clean."
Canada
Joanne
The price is ￥10,095
￥15,042 total
includes taxes & fees
Dec 7 - Dec 8
Residence Agatocle
A bedroom with a stone wall, a bed with a wooden headboard, a tray with a plant, and a window with curtains.

16. B&B Siracusa

B&B Siracusa
Santa Lucia
8.8 out of 10, Excellent, (61 reviews)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is ￥11,961
￥13,636 total
includes taxes & fees
Nov 16 - Nov 17
B&B Siracusa
A couple standing on a balcony overlooking a clear blue sea with rocky formations.

17. Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (60 reviews)
"Wonderful property, excellent staff and the most amazing view from the apartment"
Australia
Anthony
The price is ￥37,300
￥42,797 total
includes taxes & fees
Nov 15 - Nov 16
Re Dionisio Luxury Suites
A modern bathroom with a freestanding bathtub, a large mirror, and a unique geometric light fixture.

18. B&B IL MORO

B&B IL MORO
Santa Lucia
4.0 out of 10, (1 review)
"Personne sur place pour nous aider. La carte de la chambre était défectueuse dès l'arrivée. Par la suite l'électricité a manqué à 21h, nous avons du contacter les propriétaires via What's App dans le noir. Nous apprécions faire affaire avec des humains et non des applications impersonnelles et des vidéos. Le lit était petit et inconfortable. Pas d'oreiller d'extra ni de boîte de mouchoirs. Le quartier est lugubre."
Canada
Celine B. La
The price is ￥9,444
￥14,794 total
includes taxes & fees
Nov 15 - Nov 16
B&B IL MORO
A covered outdoor area with a pool, seating, and a view of the city.

19. Populus

Populus
1.0 star property
Santa Lucia
7.8 out of 10, Good, (75 reviews)
"Just stay somewhere else, plain and simple."
United States
Thomas
The price is ￥9,951
￥11,343 total
includes taxes & fees
Nov 14 - Nov 15
Populus
A modern hotel room with a bed, a bedside table, a decorative wall, and a shower area.

20. B&B L'INFIORESCENZA

B&B L'INFIORESCENZA
Santa Lucia
7.0 out of 10, Good, (4 reviews)
"A pretty good value place in Siracusa, it's not far from Ortigia so save yourself a bit of money. It's clean and the bedroom is comfy, plus all the essentials are provided, as well as a voucher for a free breakfast at the cafe downstairs. The only downside is the somewhat odd and cramped layout of the property: the bedroom and the downstairs bit are pretty spacious, but there is a narrow spiral staircase connecting them and if you want to carry your suitcases up it's a bit of a pain. Also when...
United Kingdom
Adrian
The price is ￥5,142
￥7,876 total
includes taxes & fees
Nov 15 - Nov 16
B&B L'INFIORESCENZA
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Hotels recommended for families in Santa Lucia

A historic building with a grand entrance, multiple flags, and a staircase leading to the entrance.

Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (717)
The price is ￥13,557
￥15,455 total
includes taxes & fees
Nov 30 - Dec 1
Grande Albergo Alfeo

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.
A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

Ancient ruins with a large amphitheater surrounded by trees.
Photo by William Keller
Open Photo by William Keller

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Grottasanta

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Top Santa Lucia Hotel Reviews

A balcony with a wicker chair and table, overlooking a marina with boats and buildings.
Fortaleza Charme House

Fortaleza Charme House

Fortaleza Charme House
Santa Lucia

10/10 Excellent

The hotel is quite cool - looks unimpressive from the outside but inside the rooms are very modern and clean. We had 2 rooms on the top floor with skylights which had remote-controlled shades. We were given code access to get in - which was perfect as we arrived early and dropped our bags off. We were lucky to fin street parking just across the street from the hotel. The location was awesome. Right next to the bridge to Ortigia. Plenty of coffee shops and restaurants near by. The staff...
United States
Steven
Reviewed October 10, 2026
Fortaleza Charme House

Frequently Asked Questions

What is Santa Lucia like?

Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood.

Where is the best place to stay in Santa Lucia?

Based on our traveler data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.

How many hotels can I expect to find in Santa Lucia?

Expedia has 313 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.

If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia.

Where can I learn more about changing or cancelling my trip to Santa Lucia?

For more details about changing or cancelling your trip to Santa Lucia, click here.

What are the top things to see and do in Santa Lucia?

Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

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