Santa Lucia Vacations

Book a Hotel + Flight or Car together to unlock savings

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  • Plan, book, travel with confidence

  • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Plan, book, and manage your trip all in one place

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most. Learn more about Santa Lucia
Ortigia

Ortigia

4 out of top 10 points of interest in this area
4.5/5(148 area reviews)

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

Find hotels in Ortigia

Santa Lucia Hotel Deals

Grande Albergo Alfeo

Grande Albergo Alfeo

4 out of 5
Via Nino Bixio 5 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is ￥19,851 per night from May 6 to May 7
￥19,851
￥22,630 total
May 6 - May 7
includes taxes & fees
8.6/10 Excellent! (661 reviews)
I would not agree with the 4 star rating. This hotel is centrally located just outside Ortiga old town, the breakfast was good and the rooms were spacious but that is where the positives end. The hotel is tired with peeling paint in places throughout. The patio area in front of the main doors is ...

Reviewed on Apr 19, 2026

Grande Albergo Alfeo
Caportigia Boutique Hotel

Caportigia Boutique Hotel

5 out of 5
Viale Montedoro 76 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is ￥33,196 per night from Apr 22 to Apr 23
￥33,196
￥38,381 total
Apr 22 - Apr 23
includes taxes & fees
Caportigia Boutique Hotel
Nostos rooms & Apartments

Nostos rooms & Apartments

3 out of 5
Corso Umberto I, 66 Syracuse SR
The price is ￥11,615 per night from Apr 22 to Apr 23
￥11,615
￥13,241 total
Apr 22 - Apr 23
includes taxes & fees
9/10 Wonderful! (277 reviews)
I loved this stay. Was so nice to have a kitchenette. Superb location. Staff was fantastic. Nice private terrace. Climate control worked well. Very quiet inside apartment despite being on a main street. Would absolutely stay again.

Reviewed on Apr 6, 2026

Nostos rooms & Apartments
See all 3,729 properties in Santa Lucia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Lucia vacation package cost?
Our Santa Lucia packages, which start from just , are the perfect way to save loads of cash. All you have to do is choose your preferred flights, hotels and rental cars to create your ideal escape.
How do I get a cheap travel package to Santa Lucia?
Combine your hotels and flights, throw in extras such as a rental car or activities, and save with a Santa Lucia vacation package. You won't just score big discounts on your escape — you'll have lots of choice at your fingertips too. When you book with Expedia, you can choose from more than 550 airlines and 1,000,000 hotels all over the world. Your affordable vacation begins right here, right now!
Where should I stay in Santa Lucia?
Take the hassle out of sightseeing by staying in a hotel right around the corner from Santa Lucia's iconic attractions. Cathedral of Syracuse and Temple of Apollo are two visitor favorites.
What are the top hotels in Santa Lucia?
If this will be your first time in Santa Lucia, book a room at Hotel Cavalieri or Paolanna Luxury Rooms. Both hotels offer friendly service and are popular options with many travelers.
How far in advance should I book my Santa Lucia vacation?
Smart travelers will likely want to reserve their seats early. You can normally compare international fares on Expedia up to 12 months before your flight. If you're purchasing tickets last minute, don't stress. Budget prices occasionally appear in the last weeks prior to departure.
What does an Expedia Santa Lucia travel package include?
Packages include hotels, flights and rental cars, but you can mix and match them to create your ideal Santa Lucia vacation. You can also add on some activities and experiences once you've made your booking. You're in charge! When you bundle your bookings with Expedia, you'll score discounts you won't find anywhere else.
What should I know before booking a Santa Lucia travel package?
You'll land impressive savings when you bundle your hotels, flights and rental cars into a package. Plus, booking everything in one place will make your trip planning easier. So why waste money or time? Whether you're putting together a ritzy romantic getaway or a budget family adventure, browse our package deals today.
Can I choose my airline with a Santa Lucia Expedia vacation package?
You can, and with more than 550 airlines to pick from globally, you have plenty of choice. Search the available options and find out which airline best fits your needs and budget.
If I'm not able to travel, can I cancel my Santa Lucia vacation package?
Yes, you can. We realize life doesn't always go to plan, so we're here to help if you have to make changes to your Santa Lucia vacation package. It may be possible to cancel or amend your itinerary at no cost if you've booked in the last 24 hours. Your airline, hotel or car rental company may charge you a fee if your booking was made more than 24 hours ago. Visit our Customer Service Portal for further information. Also, check your itinerary for the nitty-gritty on change fees.

Things to do

Syracuse: Bus Transfer to/from Palermo Bus station

Syracuse: Bus Transfer to/from Palermo Bus station

￥2,802
per adult
Syracuse: Bus Transfer to/from Palermo Bus station
Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves

Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves

￥5,529
per adult
Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves
Siracusa: Ortygia Island Boat Tour with Grotto Visit

Siracusa: Ortygia Island Boat Tour with Grotto Visit

￥4,608
per adult
Siracusa: Ortygia Island Boat Tour with Grotto Visit
See all activities in Syracuse
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.