Top Honeymoon Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway, Winona, MN

2 hours drive from Mayo Clinic

Stay at this 3.5-star B&B in Winona. Enjoy free breakfast, free parking, and a business center. Popular attractions Watkins Heritage Museum and Polish Cultural ...

10/10 Exceptional! (341 reviews)

"Check in was great with the owner telling us about the history of the house. Breakfast was excellent!"

Reviewed on Jul 14, 2025

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw, Rochester, MN

4 min walk from Mayo Clinic

Stay at this 3-star hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.4/10 Very Good! (197 reviews)

"Nice room, clean and friendly staff. Great location and good breakfast."

Reviewed on Jun 11, 2025

St James Hotel, a Historic Hotel of America

406 Main St., Red Wing, MN

2 hours drive from Mayo Clinic

Stay at this 3.5-star spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9/10 Wonderful! (1,004 reviews)

Lovely historical hotel!

"This hotel is absolutely stunning and a must-stay when in Red Wing. So much to explore within the building itself. Wonderful on-site restaurant with a patio and weekend music. Within walking distance of everything you need. The complimentary YMCA pass is a plus."

Reviewed on Jul 6, 2025

See all 915 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.