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Top Honeymoon Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free breakfast, free parking, and a business center. Popular attractions Watkins Heritage Museum and Polish Cultural Institute ...

10/10 Exceptional! (365 reviews)

The owner/innkeeper was lovely! A very nice host and the property is absolutely gorgeous! Truly a dream! Each room is decorated beautifully in time-accurate furnishings and feels very homey. The breakfast was delicious as well, curated and cooked by the host himself. A wonderful evening/stay for ...

Reviewed on Dec 21, 2025

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.4/10 Very Good! (201 reviews)

We were there for 3 nights while visiting Doctors at Mayo. The location is very good and is connected to the Mayo Subway. The hotel was clean and staff friendly.

Reviewed on Jan 14, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,000 reviews)

We checked in on Christmas Day 2025 and stayed 1 night. The hotel is in the heart of beautiful downtown Red Wing, MN. The hotel was beautifully decorated for the holidays and was warm and inviting. We had brunch at the beautiful Scarlet Kitchen and Bar and the food and service could not have been ...

Reviewed on Jan 5, 2026

See all 943 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.