Photo by Sara Crotts

Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Honeymoon Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business center, and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (519 reviews)

"This was an amazing experience! Such a beautiful mansion and the host was so pleasant and made you feel special and welcomed. Breakfast was incredible!!!! I will stay here again and tell my friends about this place!"

Reviewed on Jun 27, 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.6/10 Excellent! (209 reviews)

"Mayo Clinic in Rochester Minnesota is impressive. We were able to walk from our hotel through a pedestrian tunnel system to get to the hospital with access to other clinic buildings, restaurants and shopping. Very convenient for patients and families during the harsh Minnesota winters.I’m"

Reviewed on May 26, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,001 reviews)

"Nice"

Reviewed on Jun 21, 2026

See all 917 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.