South Florida Adults Only Vacations 2026

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Top Adults Only South Florida Hotels

The Southernmost Inn - Adults Only

525 United Street Key West FL

5 hours drive from Port of Miami

Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...

Paradise Inn Key West - Adults Only

819 Simonton Street Key West FL

5 hours drive from Port of Miami

Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, parking (surcharge), and a garden. Our guests praise the breakfast and the pool ...

Heron House - Adult Only

512 Simonton St Key West FL

5 hours drive from Port of Miami

Stay at this B&B in Key West. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the breakfast and the pool in our reviews. Popular attractions ...

See all 90,716 properties in South Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.