Santa Cruz Vacations

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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
A tree-lined street with parked motorcycles and cars, and a person walking.

Historical Center

7 out of top 10 points of interest in this area

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
The price is ￥19,802 per night from Aug 3 to Aug 4
￥19,802
￥21,782 total
Aug 3 - Aug 4
includes taxes & fees
9.2/10 Wonderful! (1,013 reviews)
"Staff were so friendly as we checked in. We were given a list of nearby recommendations which really helped us explore the area. Actual building was so authentic and picturesque; I’ve never stayed anywhere so beautiful! Rooms were lovely and clean. Would highly recommend."

Reviewed on Jul 12, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
Fully refundableReserve now, pay when you stay
The price is ￥7,586 per night from Aug 3 to Aug 4
￥7,586
￥8,345 total
Aug 3 - Aug 4
includes taxes & fees
8.8/10 Excellent! (1,018 reviews)
"Room was cool and clean. Service was great. Breakfast buffet was worth the price. Convenient and plentiful. Close to the cathedral, restaurants , and shopping areas."

Reviewed on Jul 13, 2026

Hotel Murillo
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
The price is ￥67,481 per night from Aug 10 to Aug 11
￥67,481
￥74,230 total
Aug 10 - Aug 11
includes taxes & fees
9.4/10 Exceptional! (1,003 reviews)
"Hôtel splendide, luxueux et très bien situé. À proximité de tous les sites majeurs, les restos, les boutiques et les grands parcs. L'hôtel rempli parfaitement sa promesse : beauté, confort et raffinement. Nous avons eu de très bonnes recommandations de restaurants, conformes à ce que nous recherchions. ..."

Reviewed on Jul 11, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
See all 413 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz vacation package cost?
Get ready to book, because a trip to Santa Cruz starts from a tempting . When you combine your hotels, flights and car rentals into a package, you'll enjoy the biggest deals.
How do I get a cheap travel package to Santa Cruz?
Just think of all the fun things you could do in Santa Cruz with a pile of extra cash in your pocket. Watch your savings stack up when you combine your travel bookings into a Santa Cruz vacation package. You have plenty of choice when it comes to booking with Expedia too. In fact, you can select from over 550 airlines and 1,000,000 properties around the world. Whether you're enjoying a break with the whole family or traveling with someone special, exploring Santa Cruz is better with a package.
Where should I stay in Santa Cruz?
Most people who visit Santa Cruz put both Seville Cathedral and Alcázar on their must-see lists. Why not choose a hotel close to one of these iconic attractions?
What are the top hotels in Santa Cruz?
Puerta Catedral Holiday Suites and San Isidoro Hostel Sevilla are among the most well-known properties in Santa Cruz. Why not check out the rates and facilities at each and then make up your mind?
How far in advance should I book my Santa Cruz vacation?
Reserving your seat early with Expedia means one less thing to have to worry about. Most carriers advertise prices up to 12 months prior to take off. This is generally the cheapest time to book. If circumstances have left you booking late, great deals to Santa Cruz sometimes emerge in the weeks leading up to departure.
What does an Expedia Santa Cruz travel package include?
Hotels, car rentals and flights — we bring you the very best deals. All you'll have to do is decide on your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and tours. Our travel packages make it easy to craft an awesome Santa Cruz trip.
What should I know before booking a Santa Cruz travel package?
You'll pick up impressive savings when you bundle your flights, hotels and rental cars into a package. Plus, booking everything in one place just makes things easier. So why waste your time or money? Whether you're putting together an upscale romantic escape or a budget family adventure, explore our vacation packages today.
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's the beauty of an Expedia package. You're in control. We have more than 550 airline partners around the world, so you have loads of choice when organizing your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes, it's possible to cancel your Santa Cruz booking if your travel plans have changed. Whether you'll be charged a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

Stay near popular Santa Cruz attractions

A courtyard with a central water feature, surrounded by columns and potted trees.

Royal Alcázar of Seville

9.6/10 (8,220 reviews)
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
See properties

Things to do

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

￥6,307
per adult
90% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Seville City Walking Tour

Seville City Walking Tour (Tip Based)

￥444
per adult
Seville City Walking Tour (Tip Based)
twilight view of manor

Granada Day Trip from Seville with Alhambra Guided Tour Included

￥31,258
per adult
86% of travellers recommend
Granada Day Trip from Seville with Alhambra Guided Tour Included
See all activities in Seville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.