San Francisco

Panama City

Photo by Hideki Yamagata
Photo by Hideki Yamagata
Photo by ‎James Barrow
Photo by ‎James Barrow
Photo by Adrian Damian
Photo by Adrian Damian
Photo by Nóra Széll
Photo by Nóra Széll
Photo by Panama Roadrunner
Photo by Panama Roadrunner

Popular places to visit

Rainy day in Panama City but the charm of this city never ends. A beautiful rainbow over the city invites us to spend a bright day in paradise. #LifeAtExpedia

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall

ATLAPA Conventions Center

Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its top-notch restaurants.

ATLAPA Conventions Center

Pacific Center

You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.

Pacific Center

Multicentro Panama

During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.

Multicentro Panama

Panama Canal Murals

You can learn about the history of Panama City with a visit to Panama Canal Murals. Stroll along the seaside in this vibrant area, or check out its lively bars.

Panama Canal Murals

Hospital Punta Pacífica

Though Hospital Punta Pacífica might be what brings you to town, perhaps you'll have a chance to explore more of Panama City while you are here.

Hospital Punta Pacífica

Things to do

Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

￥21,826
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Boat tour in the Panama Canal to Monkeys and sloths islands

Boat tour in the Panama Canal to Monkeys and sloths islands

￥10,840
per adult
92% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
La casa de papel Day tour in San Blas Islands - All inclusive- No hidden fees.

All included - Day tour in San Blas Islands - No extra fees

￥15,966
per adult
All included - Day tour in San Blas Islands - No extra fees
Full-Day SAN BLAS ISLAND & Snorkeling Tour + Transport from Panama City

Full-Day SAN BLAS ISLAND Tour + Transport from Panama City

￥21,230
per adult
Full-Day SAN BLAS ISLAND Tour + Transport from Panama City
BLISS in San Blas Islands Panama Includes Tour & Transport from Panama City

BLISS in San Blas Islands Panama Includes Tour & Transport from Panama City

￥21,092
per adult
BLISS in San Blas Islands Panama Includes Tour & Transport from Panama City
Live the Experience of a Full Day in San Blas

Live the Experience of a Full Day in San Blas

￥22,704
per adult
100% of travellers recommend
Live the Experience of a Full Day in San Blas
See all activities in Panama City

San Francisco Hotel Deals

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
The price is ￥19,024 per night from Sep 27 to Sep 28
￥19,024
￥20,926 total
Sep 27 - Sep 28
includes taxes & fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (1,092 reviews)
"Drainage was not good in the shower , not enough towels and there was not hand or face towels. Electric Outlet by tv are not working"

Reviewed on Sep 23, 2025

Megapolis Hotel Panamá
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
The price is ￥34,240 per night from Oct 10 to Oct 11
￥34,240
￥37,664 total
Oct 10 - Oct 11
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,012 reviews)
"Worth the price and the Hype"

Reviewed on Sep 19, 2025

JW Marriott Panama
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
The price is ￥20,081 per night from Oct 4 to Oct 5
￥20,081
￥22,090 total
Oct 4 - Oct 5
includes taxes & fees
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (952 reviews)
"The Sheraton is a large property, so the size lends itself to several dining options, a very large gym, spacious areas to hang out. WiFi coverage was excellent."

Reviewed on Sep 24, 2025

Sheraton Grand Panama
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ￥12,665 per night from Sep 28 to Sep 29
￥12,665
￥13,931 total
Sep 28 - Sep 29
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,340 reviews)
"The hotel is centrally located and nice. The staff was very nice and accommodating"

Reviewed on Sep 24, 2025

Decapolis Hotel Panama City
Ramada Plaza By Wyndham Panama Punta Pacífica

Ramada Plaza By Wyndham Panama Punta Pacífica

4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
The price is ￥15,911 per night from Oct 10 to Oct 11
￥15,911
￥17,502 total
Oct 10 - Oct 11
includes taxes & fees
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,056 reviews)
"From the moment I arrived, I felt completely at ease at the Ramada. The hotel's immaculate cleanliness and serene atmosphere made it a perfect escape. The staff truly went above and beyond, making me feel so welcome and cared for. I was particularly impressed by the attentiveness of the waiters, ..."

Reviewed on Sep 25, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
The price is ￥21,628 per night from Sep 27 to Sep 28
￥21,628
￥23,790 total
Sep 27 - Sep 28
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,024 reviews)
"Excellent hotel! Spacious rooms and very clean! Breakfast is superb. Second time staying in this hotel and we’ll definitely stay here again."

Reviewed on Sep 24, 2025

Las Americas Golden Tower Panama
See all 1,545 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around San Francisco

Summer time in Panama City, blue sky and sunny days to enjoy this city. #lifeatexpedia #PanamaCity #travel

Obarrio

4/5(91 area reviews)

Unique features of Obarrio include the casinos and coffeehouses. Make a stop by Calle 50 or Soho City Center while you're exploring the area.

Obarrio
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Punta Pacifica

Notable for its seaside views, restaurants, and casinos, Punta Pacifica is a sought-after destination for many travelers visiting Panama City. If you want to see some sights in the area, check out Avenida Balboa or Multiplaza Pacific Mall.

Punta Pacifica
Hard Rock Hotel Panama #StunningStructures

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Punta Paitilla
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Campo Alegre

4/5(368 area reviews)

If you're spending some time in Campo Alegre, Uruguay Street and Calle 50 are top sights worth seeing.

Campo Alegre
Panama viejo

El Cangrejo

4/5(530 area reviews)

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

El Cangrejo
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Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

Bella Vista

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