The Best Hotels Closest to Museum of Life and Science in Raleigh for 2026

Our top choices for Museum of Life and Science hotels

Hampton Inn & Suites Durham/North I-85

1.4 km from Museum of Life and Science

Amy

￥21,516 total

includes taxes & fees

Jun 28 - Jun 29

Holiday Inn Express Durham by IHG

2.2 km from Museum of Life and Science

Kathy

￥19,135 total

includes taxes & fees

Jul 5 - Jul 6

Suite, 1 King Bed with Sofa bed, Non Smoking | Premium bedding, desk, blackout drapes, iron/ironing board

Comfort Inn & Suites Durham near Duke University

Croasdaile Farm Master, 3.2 km from Museum of Life and Science

Brandi

￥17,906 total

includes taxes & fees

Jun 30 - Jul 1

Red Roof Inn Durham - Duke Univ Medical Center

2.2 km from Museum of Life and Science

Derrick

￥12,071 total

includes taxes & fees

Jun 28 - Jun 29

Stylish Durham Retreat - Walkable, Sleeps 6

2.8 km from Museum of Life and Science

￥102,763 total

includes taxes & fees

Jun 15 - Jun 16

Hilton Garden Inn Durham/University Medical Center

9th Street District, 3.3 km from Museum of Life and Science

KEVIN

￥26,747 total

includes taxes & fees

Jul 3 - Jul 4

Residence Inn Durham McPherson/Duke University Medical Cntr

Trinity Park, 3.3 km from Museum of Life and Science

Shelly

￥28,703 total

includes taxes & fees

Jun 28 - Jun 29

Hampton Inn & Suites Durham University Medical Center

4.8 km from Museum of Life and Science

Allison

￥20,227 total

includes taxes & fees

Jul 6 - Jul 7

University Inn Durham next to Duke University Medical Center

4 km from Museum of Life and Science

Becky

￥18,864 total

includes taxes & fees

Jul 3 - Jul 4

SpringHill Suites by Marriott Durham City View

4.6 km from Museum of Life and Science

Evelyn

￥23,369 total

includes taxes & fees

Jun 28 - Jun 29

The Durham Hotel

Downtown Durham, 3.6 km from Museum of Life and Science

George

￥33,895 total

includes taxes & fees

Jun 17 - Jun 18

JB Duke Hotel

5.6 km from Museum of Life and Science

Rosie

￥36,263 total

includes taxes & fees

Jul 2 - Jul 3

Aloft by Marriott Durham Downtown

American Tobacco District, 4 km from Museum of Life and Science

Lucas

￥32,437 total

includes taxes & fees

Jul 5 - Jul 6

Premium bedding, down comforters, in-room safe, desk

Durham Marriott City Center

Downtown Durham, 3.6 km from Museum of Life and Science

Nancy

￥26,240 total

includes taxes & fees

Jul 5 - Jul 6

Washington Duke Inn & Golf Club

5.9 km from Museum of Life and Science

Christopher

￥48,290 total

includes taxes & fees

Jul 8 - Jul 9

AC Hotel Durham

4.9 km from Museum of Life and Science

krishnan

￥27,077 total

includes taxes & fees

Jun 28 - Jun 29

The Lodge at Duke Medical Center

4 km from Museum of Life and Science

Tracy

￥23,154 total

includes taxes & fees

Jun 12 - Jun 13

Courtyard Durham Near Duke University/Downtown

Croasdaile Farm Master, 3.4 km from Museum of Life and Science

Marvin

￥16,884 total

includes taxes & fees

Jul 1 - Jul 2

21c Museum Hotel Durham

Downtown Durham, 3.7 km from Museum of Life and Science

Kara

￥35,213 total

includes taxes & fees

Jul 9 - Jul 10

Unscripted Durham, Part of JDV by Hyatt

Downtown Durham, 3.7 km from Museum of Life and Science

Tammy

￥22,246 total

includes taxes & fees

Jul 2 - Jul 3

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Top Museum of Life and Science Hotel Reviews

Courtyard Durham Near Duke University/Downtown

8/10 Good

"A"

21c Museum Hotel Durham

10/10 Excellent

"It was a couple date and i adore the room it was clean and well kept. I loved the decor and the museum was amazing. I also loved the food from the restaurant The only thing I didn't like was the TV It was messing up pretty bad and the room wouldn't never get cool. But When I went to the staff with my concern they was very understanding and respectful about my concerned and fix the problem right away I give them a 9/10. Even though i a little issues I will still come back. thanks again for your hospitality."

Comfort Inn & Suites Durham near Duke University

8/10 Good

"I didn’t have a lot of time, and thought the included breakfast was decent enough for my road trip. The room was very clean and quiet. I got a good nights sleep. I was tired after a long day of driving. Check-in went really fast — no problems."

Holiday Inn Express Durham by IHG

6/10 Okay

"Room was fine. Breakfast was empty. No one around to refresh food. I was not there at the last minute so I was confused why the trays sat empty for so long. I find it amusing that the picture I was shown when I decided to fill this out was one of the breakfast buffet complete with full trays of omelets..."

Curated Duke Retreat • Minutes to DPAC, downtown • Espresso, Eco+, Fire Pit

10/10 Excellent

"We had a fantastic stay at Kristin’s cozy cottage. She went out of her way to make us feel welcome. I frankly feel I owe her a hand written thank you note because it felt like I was staying at a friend’s home not a vacation rental. If you want a cozy, clean cottage to come home to, a comfy bed and a well equipped kitchen, Kristin’s home is perfect. I would do it all over again and recommend highly to a friend."

Walk to Duke & Dining • Charming Historic 2BR

10/10 Excellent

"Emily was extremely communicative, both in answering all my questions and responding quickly. She even got an air mattress for us as we needed one more something to sleep on. She knew we were having a problem with VRBO messing up our reservation, with short time for us to find a new location, and she went above and beyond to help us find our place. She was fantastic!"

Hotels near other Museum of Life and Science attractions

Brightleaf Square

4.8/5 (8 reviews)

You can browse for the perfect souvenirs at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.

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Frequently asked questions

What's the area like around Museum of Life and Science?

Museum of Life and Science is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 11 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Museum of Life and Science?

Hampton Inn & Suites Durham/North I-85 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.8 mi (1.4 km) from Museum of Life and Science. Other good options within 5 miles include Holiday Inn Express Durham by IHG and Courtyard Durham Near Duke University/Downtown.

How many hotels will I find close to Museum of Life and Science?

Expedia has 11 hotels and other accommodations within a mile from Museum of Life and Science.

If I need to cancel the hotel reservation for my stay near Museum of Life and Science, will I receive a refund?

Yes, most hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to view the best deals near Museum of Life and Science.

Where can I learn more about changing or cancelling my trip in the area near Museum of Life and Science?

To access more information about picking new dates or cancelling your stay near Museum of Life and Science, go to https://www.expedia.com/service/.

What can I see and do near Museum of Life and Science?

You'll want to browse the exhibits at Nasher Museum of Art at Duke University and Bennett Place. Explore landmarks like American Tobacco Campus, Cameron Indoor Stadium, and Scarborough House. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Museum of Life and Science, Raleigh from ￥12,071

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Our top choices for Museum of Life and Science hotels

Hampton Inn & Suites Durham/North I-85

Holiday Inn Express Durham by IHG

Comfort Inn & Suites Durham near Duke University

Red Roof Inn Durham - Duke Univ Medical Center

Stylish Durham Retreat - Walkable, Sleeps 6

Hilton Garden Inn Durham/University Medical Center

Residence Inn Durham McPherson/Duke University Medical Cntr

Hampton Inn & Suites Durham University Medical Center

University Inn Durham next to Duke University Medical Center

SpringHill Suites by Marriott Durham City View

The Durham Hotel

JB Duke Hotel

Aloft by Marriott Durham Downtown

Durham Marriott City Center

Washington Duke Inn & Golf Club

AC Hotel Durham

The Lodge at Duke Medical Center

Courtyard Durham Near Duke University/Downtown

21c Museum Hotel Durham

Unscripted Durham, Part of JDV by Hyatt

Top Museum of Life and Science Hotel Reviews

Courtyard Durham Near Duke University/Downtown

Hotels near other Museum of Life and Science attractions

Brightleaf Square

Frequently asked questions