Find hotels near Museum of Life and Science, Raleigh from ￥10,476

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 16 - Dec 17
Tomorrow
Dec 17 - Dec 18
This weekend
Dec 19 - Dec 21
Next weekend
Dec 26 - Dec 28

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Museum of Life and Science hotels

Free daily buffet breakfast
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
1.4 km from Museum of Life and Science
9.0 out of 10, Wonderful, (1004)
"Nice place to stay and close to everything. "
United States
Christy
The price is ￥15,997
￥18,157 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
2.2 km from Museum of Life and Science
8.8 out of 10, Excellent, (952)
"Room was great"
United States
Barbara
The price is ￥14,261
￥16,186 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Express Durham by IHG
Premium bedding, desk, blackout drapes, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 3.2 km from Museum of Life and Science
8.6 out of 10, Excellent, (1004)
"Loved our stay"
United States
Brian
The price is ￥14,652
￥16,631 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Inn & Suites Durham near Duke University
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
2.2 km from Museum of Life and Science
6.8 out of 10, (1002)
"Good motel...clean, easy acess "
United States
Howard
The price is ￥8,997
￥10,476 total
includes taxes & fees
Dec 28 - Dec 29
Red Roof Inn Durham - Duke Univ Medical Center
Miscellaneous
Super 8 by Wyndham Durham/University Area NC

Super 8 by Wyndham Durham/University Area NC

Super 8 by Wyndham Durham/University Area NC
2.0 star property
2.1 km from Museum of Life and Science
5.0 out of 10, (344)
"The environment was not pleasant "
United States
Denise
The price is ￥9,882
￥11,217 total
includes taxes & fees
Dec 26 - Dec 27
Super 8 by Wyndham Durham/University Area NC
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 3.3 km from Museum of Life and Science
9.2 out of 10, Wonderful, (459)
"Hotel was great - very friendly staff."
United States
Lisa
The price is ￥20,754
￥23,555 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Residence Inn Durham McPherson/Duke University Medical Cntr
Reception
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 3.4 km from Museum of Life and Science
9.2 out of 10, Wonderful, (1002)
"Clean rooms, nice staff. Clean hotel. Ample parking. "
United States
Emana
The price is ￥14,920
￥16,934 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton Garden Inn Durham/University Medical Center
Outdoor dining
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 3.6 km from Museum of Life and Science
9.0 out of 10, Wonderful, (638)
"Perfect place to stay for an easy walk to see a show at the charming Carolina Theater. Food, service and atmosphere were outstanding. "
United States
Jo
The price is ￥28,833
￥32,726 total
includes taxes & fees
Dec 20 - Dec 21
The Durham Hotel
Lobby
Durham Marriott City Center

Durham Marriott City Center

Durham Marriott City Center
3.5 star property
Downtown Durham, 3.6 km from Museum of Life and Science
8.8 out of 10, Excellent, (823)
"The room was clean. The staff was very helpful and the food was good. "
United States
Tia
The price is ￥20,771
￥23,574 total
includes taxes & fees
Dec 22 - Dec 23
Durham Marriott City Center
BBQ/picnic area
Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown
3.0 star property
Croasdaile Farm Master, 3.3 km from Museum of Life and Science
8.2 out of 10, Very Good, (1002)
"Great place "
United States
Silvia
The price is ￥16,338
￥18,544 total
includes taxes & fees
Dec 26 - Dec 27
Courtyard Durham Near Duke University/Downtown
Front of property
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 4.1 km from Museum of Life and Science
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is ￥26,197
￥29,734 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Aloft Durham Downtown
Hallway
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center
2.0 star property
4 km from Museum of Life and Science
8.8 out of 10, Excellent, (1003)
"Great place"
United States
Chase
The price is ￥16,601
￥18,842 total
includes taxes & fees
Dec 24 - Dec 25
University Inn Durham next to Duke University Medical Center
Terrace/patio
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
4.8 km from Museum of Life and Science
9.6 out of 10, Exceptional, (391)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is ￥15,997
￥18,157 total
includes taxes & fees
Dec 26 - Dec 27
Hampton Inn & Suites Durham University Medical Center
Exterior
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
4.6 km from Museum of Life and Science
9.2 out of 10, Wonderful, (453)
"Great room, showers amazing, great staff. "
United States
Micah
The price is ￥15,966
￥18,122 total
includes taxes & fees
Dec 28 - Dec 29
SpringHill Suites by Marriott Durham City View
Interior entrance
21c Museum Hotel Durham

21c Museum Hotel Durham

21c Museum Hotel Durham
4.0 star property
Downtown Durham, 3.7 km from Museum of Life and Science
8.4 out of 10, Very Good, (1002)
"Overall good hotel and friendly staff. Building and rooms show some age but that is part of the charm. Enjoyable stay. "
United States
Lisa H
The price is ￥24,972
￥29,119 total
includes taxes & fees
Dec 22 - Dec 23
21c Museum Hotel Durham
Balcony view
Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt
3.5 star property
Downtown Durham, 3.7 km from Museum of Life and Science
8.2 out of 10, Very Good, (1003)
"Staff was nice, room was large and very clean, location was excellent"
United States
Janice
The price is ￥19,686
￥24,981 total
includes taxes & fees
Dec 22 - Dec 23
Unscripted Durham, Part of JDV by Hyatt
Lobby sitting area
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

The Lodge at Duke Medical Center
3.0 star property
4 km from Museum of Life and Science
8.4 out of 10, Very Good, (1005)
"Older property but very convenient and clean for our quick trip. "
United States
Stacie
The price is ￥19,996
￥22,694 total
includes taxes & fees
Dec 17 - Dec 18
The Lodge at Duke Medical Center
Lobby
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
4.9 km from Museum of Life and Science
9.2 out of 10, Wonderful, (614)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is ￥18,314
￥20,787 total
includes taxes & fees
Dec 20 - Dec 21
AC Hotel Durham
Exterior
JB Duke Hotel

JB Duke Hotel

JB Duke Hotel
4.0 star property
5.6 km from Museum of Life and Science
9.4 out of 10, Exceptional, (539)
"Excellent on all levels! Will definitely stay here again!"
United States
Cherie Nan
The price is ￥23,074
￥26,189 total
includes taxes & fees
Dec 24 - Dec 25
JB Duke Hotel
Restaurant
Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
4.0 star property
5.9 km from Museum of Life and Science
9.4 out of 10, Exceptional, (1003)
"Everything fabulous!"
United States
Terri
The price is ￥24,554
￥27,870 total
includes taxes & fees
Dec 18 - Dec 19
Washington Duke Inn & Golf Club
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Museum of Life and Science Hotel Reviews

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

10/10 Excellent
"Beautiful newly remodeled room."
Jo A. 1-night trip
Posted 6 days ago
Comfort Inn & Suites Durham near Duke University

Hotels near other Museum of Life and Science attractions

Brightleaf Square

You can browse for the perfect souvenirs at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.
See properties

Vietnam Veterans Living Memorial

You can find out about the history of Durham with a visit to Vietnam Veterans Living Memorial. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
See properties

Frequently asked questions

What's the area like around Museum of Life and Science?
Museum of Life and Science is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 9 hotels and other accommodations you'll find within a mile.
What's the best place to stay near Museum of Life and Science?
Hampton Inn & Suites Durham/North I-85 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.8 mi (1.4 km) from Museum of Life and Science. Other good options within 5 miles include Holiday Inn Express Durham by IHG and Comfort Inn & Suites Durham near Duke University.
How many hotels will I find close to Museum of Life and Science?
Expedia has 9 hotels and other accommodations within a mile from Museum of Life and Science.
If I need to cancel the hotel reservation for my stay near Museum of Life and Science, will I receive a refund?
Yes, most hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to view the best deals near Museum of Life and Science.
Where can I learn more about changing or cancelling my trip in the area near Museum of Life and Science?
To access more information about picking new dates or cancelling your stay near Museum of Life and Science, go to https://www.expedia.com/service/.
What can I see and do near Museum of Life and Science?
You'll want to browse the exhibits at Nasher Museum of Art at Duke University and Bennett Place. Explore landmarks like American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium. You can watch performances at Carolina Theatre, Durham Performing Arts Center, and Manbites Dog Theater if you're interested in local theater.

Explore a world of travel with Expedia