Hannibal, MO
Travel Guide





Visit Hannibal

Quality Inn & Suites Hannibal West
Clean and comfortable. Nice hot breakfast. Great staff, very friendly and welcoming.
Reviewed on Jan 15, 2026

Sleep Inn & Suites Hannibal West
Love that I could bring my cat. This is 4th stay, largely due to the cost of a pet. The hotell is clean and I feel safe. Nice having restaurants so close. Will stay again on my next cross country trip.
Reviewed on Jan 13, 2026

Best Western On The River
Stay was great. Thank you
Reviewed on Jan 16, 2026

Lighthouse Inn & Suites
Average room
Reviewed on Dec 17, 2025

The John Sydney House - Family and Pet Friendly Historic Home Downtown
Wonderful place to stay. Full of Hannibal charm in a terrific historic area. Owners were prompt with replies and extremely helpful. Rooms are large, beds comfortable, and great kitchen. Walkable to restaurants and the Mark Twain spots. Highly recommend.
Reviewed on Dec 31, 2025

Guest House with a River View, located downtown Hannibal, MO—- No Cleaning Fee
Very nice place to stay. The vicinity next to the busy road, while a little unsettling at first, was NO problem at all. Convenient to museums and restaurants with easy walks. Something I comment with 90% of vacation rentals…..Kleenex??!! Why can’t a box of tissue be thought of by property managers? ...
Reviewed on Sep 23, 2025
Popular places to visit
Mark Twain Cave
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this walkable area, you can savor the top-notch restaurants.
Mark Twain Boyhood Home and Museum
Find out about the history of Hannibal when you take a trip to Mark Twain Boyhood Home and Museum. While in this walkable area, you can savor the top-notch restaurants.
Mark Twain Cave and Cameron Cave
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this family-friendly area, you can savor the top-notch restaurants.
Hannibal Regional Hospital
Though Hannibal Regional Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Hannibal while you are here.
Rockcliffe Mansion
Find out about the history of Hannibal when you spend time at Rockcliffe Mansion. While in this walkable area, you can savor the top-notch restaurants.
Lovers Leap
Find out about the history of Hannibal with a stop at Lovers Leap. While in this walkable area, you can savor the top-notch restaurants.
Things to do

Mark Twains Hannibal Smartphone Walking Tour Plays as you walk
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