A calm body of water, a sandy beach, and a forested area in the distance.

Find Resorts & Hotels with Spas in Cape Girardeau, MO

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Check availability on Cape Girardeau Resorts & Hotels with Spas

Tonight
Aug 21 - Aug 22
Tomorrow
Aug 22 - Aug 23
This weekend
Aug 21 - Aug 23
Next weekend
Aug 28 - Aug 30

Our top choices for Cape Girardeau hotels with a spa

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A buffet with labeled containers of omelets and other dishes.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A hotel room with a bed, a desk, a chair, a kitchenette, and a bathroom.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
￥16,213
￥18,291 total
includes taxes & fees
Sep 22 - Sep 23
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
View all properties

Choose what matters most at spa hotels in Cape Girardeau

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Cape Girardeau Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great"
Mike 2-night trip
Posted 14 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Top notch all the way!"
Jill 1-night trip
Posted 1 day ago
Drury Inn & Suites Cape Girardeau

Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia's 66 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Century Casino & Hotel Cape Girardeau, Hunter Valley Winery, and Trail of Tears State Park. If you have a bit of extra time while you're in the area, you might want to check out Shawnee National Forest and Mississippi River.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.

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