A calm body of water, a sandy beach, and a forested area in the distance.

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Check availability on Cape Girardeau Resorts & Hotels with Spas

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Our top choices for Cape Girardeau hotels with a spa

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

1. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (699 reviews)
"Clean, quiet, comfortable room. Very comfortable beds."
United States
Renee
The price is ￥16,928
￥19,097 total
includes taxes & fees
Nov 3 - Nov 4
The Riverview
A spacious living room with a sofa set, a coffee table, and a dining area.

2. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (556 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is ￥18,293
￥20,727 total
includes taxes & fees
Nov 15 - Nov 16
Courtyard by Marriott Cape Girardeau Downtown
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

3. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,007 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is ￥15,754
￥17,772 total
includes taxes & fees
Nov 8 - Nov 9
Drury Plaza Hotel Cape Girardeau Conference Center
Two armchairs with a patterned upholstery, a small round table with a vase of flowers, and a large abstract painting on the wall.

4. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (856 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is ￥15,375
￥17,345 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Cape Girardeau I 55 East
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

5. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is ￥15,598
￥17,753 total
includes taxes & fees
Nov 30 - Dec 1
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

6. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, spacious suite, enjoyable kick back and breakfast!"
United States
Mary
The price is ￥14,179
￥15,997 total
includes taxes & fees
Nov 8 - Nov 9
Drury Inn & Suites Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

7. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,003 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is ￥11,343
￥12,797 total
includes taxes & fees
Nov 8 - Nov 9
Pear Tree Inn Cape Girardeau West
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

8. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (239 reviews)
"Great hotel…!!"
United States
Carlos
The price is ￥15,937
￥17,978 total
includes taxes & fees
Nov 8 - Nov 9
Fairfield Inn & Suites by Marriott Cape Girardeau
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

9. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (199 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is ￥14,083
￥16,029 total
includes taxes & fees
Nov 9 - Nov 10
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

10. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (1,000 reviews)
"Nice clean room"
United States
James
The price is ￥11,187
￥13,487 total
includes taxes & fees
Nov 22 - Nov 23
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

11. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.0 out of 10, Good, (816 reviews)
"Clean rooms, nice staff"
United States
Dayanita
The price is ￥9,359
￥10,559 total
includes taxes & fees
Nov 15 - Nov 16
Quality Inn Cape Girardeau North
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

12. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.2 out of 10, (243 reviews)
"Room was clean, bed was comfortable, staff was friendly, parking was easy. It was an older hotel and could use some renovation but would definitely stay again."
United States
Jaime
The price is ￥11,029
￥12,883 total
includes taxes & fees
Nov 3 - Nov 4
Town House Inn Cape Giradreau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Cape Girardeau

Pool
Breakfast included

Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Fab place, staff were great,very helpful. Friendly sit, will return"
ray 3-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau

Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia's 69 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Century Casino & Hotel Cape Girardeau, Show Me Center, and Hunter Valley Winery. If you have a bit of extra time while you're in the area, you might want to check out Trail of Tears State Park and Shawnee National Forest.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.