Find 5 Star Hotels in Palo Alto, CA from ￥22,522

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Palo Alto 5 Star Hotels

Tonight
Dec 28 - Dec 29
Tomorrow
Dec 29 - Dec 30
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Palo Alto 5-star hotels

Cocktail bar, pool views, open daily
Shashi Hotel Mountain View Palo Alto

Shashi Hotel Mountain View Palo Alto

Shashi Hotel Mountain View Palo Alto
5.0 star property
Mountain View
9.4 out of 10, Exceptional, (1213)
"Perfect place to stay and enjoy "
United States
Ali
The price is ￥22,969
￥25,311 total
includes taxes & fees
Jan 17 - Jan 18, 2026
Shashi Hotel Mountain View Palo Alto
Outdoor pool
Four Seasons Hotel Silicon Valley at East Palo Alto

Four Seasons Hotel Silicon Valley at East Palo Alto

Four Seasons Hotel Silicon Valley at East Palo Alto
5.0 star property
East Palo Alto
9.4 out of 10, Exceptional, (667)
"Wonderful stay "
United States
Cindy
The price is ￥56,365
￥64,085 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Four Seasons Hotel Silicon Valley at East Palo Alto
Outdoor pool
Rosewood Sand Hill

Rosewood Sand Hill

Rosewood Sand Hill
5.0 star property
Menlo Park
9.4 out of 10, Exceptional, (276)
"Really great hotel and my go to place for anything in Palo Alto "
United States
Lisa
The price is ￥126,117
￥157,580 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Rosewood Sand Hill
Meeting facility
Nobu Hotel Palo Alto

Nobu Hotel Palo Alto

Nobu Hotel Palo Alto
5.0 star property
University South
9.2 out of 10, Wonderful, (434)
"Beautiful hotel. "
United States
Dianne
The price is ￥61,845
￥71,551 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Nobu Hotel Palo Alto
Exterior
Clement Palo Alto – All-Inclusive Urban Resort

Clement Palo Alto – All-Inclusive Urban Resort

Clement Palo Alto – All-Inclusive Urban Resort
5.0 star property
Palo Alto
10.0 out of 10, Exceptional, (112)
"Great hotel!!"
United States
Matthew
The price is ￥74,914
￥91,915 total
includes taxes & fees
Dec 29 - Dec 30
Clement Palo Alto – All-Inclusive Urban Resort
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Palo Alto.
The Ameswell Hotel

The Ameswell Hotel

800 Moffett Blvd Mountain View CA
The price is ￥20,164 per night from Dec 29 to Dec 30
￥20,164
￥22,522 total
Dec 29 - Dec 30
includes taxes & fees
9.6/10 Exceptional! (1,145 reviews)
Still don't see what you're looking for?
See all properties in Palo Alto.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Palo Alto

Silicon Valley's heart offers visitors the chance to tour Stanford's iconic campus and stroll University Avenue's tech-inspired shops. Bike the flat, tree-lined neighborhoods where garage startups became tech giants, then hike the rolling hills of Foothills Park when you need a break.

See all hotels in Palo Alto
F688EF PALO ALTO, USA - OCT 22 2014

Top Palo Alto Hotel Reviews

Four Seasons Hotel Silicon Valley at East Palo Alto

Four Seasons Hotel Silicon Valley at East Palo Alto

10/10 Excellent
"The room was immaculate so clean and nice and comfortable enjoyed the view and location"
Frank 1-night trip
Posted 5 days ago
Four Seasons Hotel Silicon Valley at East Palo Alto

Frequently asked questions

What are the best 5-star hotels in Palo Alto?
Based on Expedia traveler reviews, Nobu Hotel Palo Alto, Clement Palo Alto – All-Inclusive Urban Resort and Four Seasons Hotel Silicon Valley at East Palo Alto are among the best 5-star hotels in Palo Alto. Providing first-rate amenities and exemplary service, you'll enjoy an indulgent and comfortable stay.
How much does it cost to stay in a 5-star hotel in Palo Alto?
The amount you pay for a 5-star hotel in Palo Alto can vary based on what time of year you travel and how long you plan to be away, among other factors. Use our price per night filter and other search tools to land the best deal on a high-end stay.

  • Search for the lowest price per night from ￥22,522

What makes a hotel 5 stars in Palo Alto?
In Palo Alto, a hotel needs to provide a specific amount of upscale features to earn a 5-star rating. These may include on-site gyms, gourmet restaurants, saunas and spas, premium bedding, luxury bathroom products and more. What also sets 5-star hotels apart is their guest-focused service. You'll enjoy things like concierge services, in-room massages and nightly turn-down services. Some may even offer special touches like welcome gifts.