Find hotels in Wapello, IA from ￥9,357

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Dec 10 - Dec 11
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Dec 11 - Dec 12
This weekend
Dec 12 - Dec 14
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Dec 19 - Dec 21

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Our top choices for Wapello hotels

Reception
Quality Inn & Suites Mount Pleasant

Quality Inn & Suites Mount Pleasant

Quality Inn & Suites Mount Pleasant
2.5 star property
Mount Pleasant
7.8 out of 10, Good, (111)
"Very happy with my stay "
United States
timothy
The price is ￥8,354
￥9,357 total
includes taxes & fees
Dec 14 - Dec 15
Quality Inn & Suites Mount Pleasant
Reception
Hampton Inn Muscatine

Hampton Inn Muscatine

Hampton Inn Muscatine
2.5 star property
Muscatine
8.4 out of 10, Very Good, (462)
"Nice stay"
United States
Bradlee Dean
The price is ￥14,208
￥15,913 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn Muscatine
Free daily buffet breakfast
Holiday Inn Express Hotel & Suites Burlington by IHG

Holiday Inn Express Hotel & Suites Burlington by IHG

Holiday Inn Express Hotel & Suites Burlington by IHG
2.5 star property
Burlington
8.6 out of 10, Excellent, (463)
"Friendly staff and very clean hotel"
United States
Julie
The price is ￥18,851
￥21,715 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express Hotel & Suites Burlington by IHG
Suite, Multiple Beds, Non Smoking | Iron/ironing board, free WiFi, bed sheets
Comfort Inn Muscatine near Hwy 61

Comfort Inn Muscatine near Hwy 61

Comfort Inn Muscatine near Hwy 61
2.5 star property
Muscatine
7.8 out of 10, Good, (214)
"great room, best breakfast each morning. Made my vacation very enjoyable."
United States
RICHARD
The price is ￥9,997
￥11,195 total
includes taxes & fees
Dec 26 - Dec 27
Comfort Inn Muscatine near Hwy 61
Indoor pool
AmericInn by Wyndham West Burlington

AmericInn by Wyndham West Burlington

AmericInn by Wyndham West Burlington
2.5 star property
West Burlington
7.0 out of 10, Good, (828)
"Hair in the tub and bed not always made up. Great breakfast and early, loved it."
United States
james
The price is ￥9,597
￥10,748 total
includes taxes & fees
Jan 4 - Jan 5, 2026
AmericInn by Wyndham West Burlington
Exterior
Best Western Mt. Pleasant Inn

Best Western Mt. Pleasant Inn

Best Western Mt. Pleasant Inn
2.5 star property
Mount Pleasant
8.2 out of 10, Very Good, (776)
"Was fine for an overnight stop"
United States
Jeanne
The price is ￥11,256
￥12,606 total
includes taxes & fees
Dec 16 - Dec 17
Best Western Mt. Pleasant Inn
Breakfast, lunch, dinner served; American cuisine
The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel

The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel

The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel
4.0 star property
Muscatine
9.6 out of 10, Exceptional, (277)
"Great Hotel. The restaurant, Maxwell's was very good."
United States
Dennis
The price is ￥26,503
￥29,684 total
includes taxes & fees
Jan 9 - Jan 10, 2026
The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel
Free buffet breakfast
Quality Inn Burlington near Hwy 34

Quality Inn Burlington near Hwy 34

Quality Inn Burlington near Hwy 34
2.5 star property
Burlington
7.4 out of 10, Good, (400)
"well cared for inexpensive property "
United States
Christopher
The price is ￥10,952
￥12,266 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Quality Inn Burlington near Hwy 34
Water park
Fun City Resort Hotel

Fun City Resort Hotel

Fun City Resort Hotel
3.5 star property
Burlington
8.4 out of 10, Very Good, (294)
"Room was great! "
United States
Gail
Fun City Resort Hotel
Reception
The Sage Hotel

The Sage Hotel

The Sage Hotel
2.0 star property
Muscatine
6.8 out of 10, (55)
"Awesome "
United States
Dauda
The Sage Hotel
Exterior
Best Western Muscatine / Pearl City Hotel

Best Western Muscatine / Pearl City Hotel

Best Western Muscatine / Pearl City Hotel
2.5 star property
Muscatine
8.6 out of 10, Excellent, (499)
"Best service "
United States
Hector
The price is ￥13,999
￥15,679 total
includes taxes & fees
Dec 16 - Dec 17
Best Western Muscatine / Pearl City Hotel
Front of property - evening/night
Fairfield Inn & Suites by Marriott Burlington

Fairfield Inn & Suites by Marriott Burlington

Fairfield Inn & Suites by Marriott Burlington
2.5 star property
Burlington
8.4 out of 10, Very Good, (295)
"It was quiet & they gave us water, when we checked in, was hot out, so that was so nice!"
United States
Loren
The price is ￥17,105
￥19,667 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Fairfield Inn & Suites by Marriott Burlington
Casino
The Catfish Bend Inn & Spa

The Catfish Bend Inn & Spa

The Catfish Bend Inn & Spa
3.5 star property
Burlington
9.2 out of 10, Wonderful, (320)
"Staff was friendly and helpful. Accomodations were excellent."
United States
Phillip
The price is ￥23,089
￥26,597 total
includes taxes & fees
Dec 13 - Dec 14
The Catfish Bend Inn & Spa
Exterior
Hampton Inn & Suites Burlington

Hampton Inn & Suites Burlington

Hampton Inn & Suites Burlington
2.5 star property
Burlington
9.6 out of 10, Exceptional, (305)
"Very clean and rooms are huge!"
United States
Chad
The price is ￥19,816
￥23,611 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn & Suites Burlington
Front of property
Evans Holly Grove Inn B&B

Evans Holly Grove Inn B&B

Evans Holly Grove Inn B&B
4.0 star property
Burlington
9.6 out of 10, Exceptional, (195)
"Delicious breakfast!!!"
United States
Geremy
The price is ￥19,112
￥21,406 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Evans Holly Grove Inn B&B
The Chelsea Suite | Private kitchen | Full-size fridge, microwave, oven, stovetop
Hall Building

Hall Building

Hall Building
2.0 star property
Aledo
The price is ￥38,792
￥41,112 total
includes taxes & fees
Dec 23 - Dec 24
Hall Building
House (1 Bedroom) | Interior
Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
3.0 star property
Biggsville
10.0 out of 10, Exceptional, (2)
"Outstanding value and extremely nice place, you won't be disappointed. "
United States
Joe
The price is ￥16,202
￥31,558 total
includes taxes & fees
Dec 12 - Dec 13
Idyllic Biggsville Vacation Rental: 10 Mi to River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Wapello

Along the banks of the mighty Mississippi, this charming river town invites visitors to explore Chatauqua Park's natural beauty and peaceful surroundings. History buffs and outdoor enthusiasts can venture to nearby Lover's Leap Swinging Bridge or spend an exciting evening watching local races at CJ Speedway.

See all hotels in Wapello
The Mississippi River near Hannibal, Missouri, USA

Top Wapello Hotel Reviews

AmericInn by Wyndham Muscatine

AmericInn by Wyndham Muscatine

10/10 Excellent
"The breakfast was good but it was all carbs it would of been good to do scramble eggs. But other than that ir was very good."
Rhonda 2-night trip
Posted 2 days ago
AmericInn by Wyndham Muscatine

More cheap stays in Wapello

Super 8 by Wyndham Burlington

Super 8 by Wyndham Burlington

3001 Kirkwood St Burlington IA
The price is ￥8,475 per night from Jan 10 to Jan 11
￥8,475
￥9,492 total
Jan 10 - Jan 11, 2026
includes taxes & fees
6/10 (756 reviews)

Frequently asked questions

Where is the best place for a stay in Wapello?
Located 25 mi (40.2 km) from the heart of Wapello, Fun City Resort Hotel is a top choice for your stay based on our traveler data. Two other options for your visit to the area are The Catfish Bend Inn & Spa and AmericInn by Wyndham West Burlington. See all available top hotels, or vacation rentals in Wapello.
What are some of the best vacation home rentals in Wapello?
Oquawka Cottage With River View: This vacation home rental near Wapello is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Wapello.
If I need to cancel my hotel reservation in Wapello, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Wapello.
Where can I learn more about changing or cancelling my trip to Wapello?
For more details about picking new dates or cancelling your trip to Wapello, click here.
What's the best place to stay near Southeast Iowa Regional Airport (BRL)?
Comfort Suites Burlington is a popular 3-star hotel featuring free breakfast and free parking. It's located a short 1.4 mi (2.2 km) from Southeast Iowa Regional Airport. Other choices near the airport include Evans Holly Grove Inn Bed and Breakfast and The PZAZZ! Resort Hotel and Catfish Bend Inn & Spa.
What is staying in Wapello like?
Visitors are sure to enjoy all that Wapello has to offer. There are 66 hotels and other accommodations in the surrounding area. Find out more about Wapello.
What should I see while I'm in Wapello?
A favorite place to visit is Mississippi River. You'll also find Cairo Woods Wildlife Area and Chatauqua Park in the area. Check out what more to see and do in Expedia's Wapello guide.
What's the seasonal weather like in Wapello?
The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 30°F. The snowiest months in Wapello are January, November, February, and December, with each month seeing an average of 7 inches of snowfall.

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