A bench, a bicycle, and a lake surrounded by trees.

Search Vacation Homes in Upstate South Carolina

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Oct 30 - Nov 1
In two months
Dec 11 - Dec 13
In three months
Jan 8 - Jan 10
In four months
Feb 5 - Feb 7

Our top choices for Upstate South Carolina vacation homes

A modern kitchen with white cabinets, stainless steel appliances, a granite countertop, and a built-in oven.

1. The Blue Bungalow by Unity Park - Newly Renovated

The Blue Bungalow by Unity Park - Newly Renovated
Woodside Cotton Mill Village Historic District
9.8 out of 10, Exceptional, (113 reviews)
"Fully equipped, comfortable beds…everything to make for an enjoyable stay. "
United States
Ron E.
The price is ￥15,673
￥40,401 total
includes taxes & fees
Oct 25 - Oct 26
The Blue Bungalow by Unity Park - Newly Renovated
Private kitchen

2. Skyline Split B Retreat Close to Everything You Need! Quiet, Clean & Convenient.

Skyline Split B Retreat Close to Everything You Need! Quiet, Clean & Convenient.
Woodside Cotton Mill Village Historic District
9.8 out of 10, Exceptional, (11 reviews)
"It was such a comfy little house and check in was very convenient and it’s close to a lot of things."
United States
lisa E.
The price is ￥13,773
￥42,142 total
includes taxes & fees
Nov 4 - Nov 5
Skyline Split B Retreat Close to Everything You Need! Quiet, Clean & Convenient.
A living room with a grey sofa, a black coffee table, a lamp, and a painting on the wall.

3. Apt. near Downtown Greenville (2BR/1BA, 3 beds)

Apt. near Downtown Greenville (2BR/1BA, 3 beds)
Greenville
10.0 out of 10, Exceptional, (12 reviews)
"It was clean and quiet..I will stay here again. "
United States
Kimberly S.
The price is ￥14,325
￥26,229 total
includes taxes & fees
Nov 3 - Nov 4
Apt. near Downtown Greenville (2BR/1BA, 3 beds)
A modern kitchen with stainless steel appliances, white cabinetry, and a herringbone tile backsplash.

4. Modern 2BR • Great for Work & Family - 6 Min from Downtown Greenville

Modern 2BR • Great for Work & Family - 6 Min from Downtown Greenville
Greenville
10.0 out of 10, Exceptional, (7 reviews)
"We had a great stay in this super cute home! It was perfect for what we needed while attending a conference in town for a few days. We really appreciated the heads up about the construction in the neighborhood from the host."
United States
Anonymous traveler
The price is ￥19,354
￥38,042 total
includes taxes & fees
Oct 20 - Oct 21
Modern 2BR • Great for Work & Family - 6 Min from Downtown Greenville
A living room with a sofa, a coffee table, a fireplace, and a television mounted on the wall.

5. 3/2 Retreat, Walk to DT Simpsonville, Fire Pit

3/2 Retreat, Walk to DT Simpsonville, Fire Pit
Simpsonville
The price is ￥17,904
￥49,710 total
includes taxes & fees
Nov 3 - Nov 4
3/2 Retreat, Walk to DT Simpsonville, Fire Pit
A modern kitchen with white cabinetry, a stainless steel stove, and a microwave.

6. Family-Friendly 3/2 Home Near Prisma, Fenced Yard

Family-Friendly 3/2 Home Near Prisma, Fenced Yard
Greenville
10.0 out of 10, Exceptional, (11 reviews)
"Great location and accommodations."
United States
Susan B B.
The price is ￥16,892
￥50,101 total
includes taxes & fees
Oct 26 - Oct 27
Family-Friendly 3/2 Home Near Prisma, Fenced Yard
A modern kitchen with white cabinets, a stainless steel refrigerator, a granite countertop, and a built-in washing machine.

7. Cozy 2BR Retreat: Pets, Near Arena & Parks

Cozy 2BR Retreat: Pets, Near Arena & Parks
Greenville
The price is ￥19,330
￥53,131 total
includes taxes & fees
Oct 26 - Oct 27
Cozy 2BR Retreat: Pets, Near Arena & Parks
A porch with two wooden chairs and a table, a potted plant, and a view of a blue house in the background.

8. Charming 2BR Walkable to Swamp Rabbit Trail

Charming 2BR Walkable to Swamp Rabbit Trail
Greenville
10.0 out of 10, Exceptional, (10 reviews)
"Cozy clean"
United States
Demarcus L.
The price is ￥16,927
￥42,003 total
includes taxes & fees
Nov 3 - Nov 4
Charming 2BR Walkable to Swamp Rabbit Trail
A modern kitchen with white cabinetry, stainless steel appliances, and a blue accent wall.

9. 3BR Retreat Near Augusta Rd & Downtown w/ Patio

3BR Retreat Near Augusta Rd & Downtown w/ Patio
Greenville
10.0 out of 10, Exceptional, (4 reviews)
"Very nice"
United States
wyatt s.
The price is ￥26,295
￥61,141 total
includes taxes & fees
Nov 9 - Nov 10
3BR Retreat Near Augusta Rd & Downtown w/ Patio
A modern kitchen with white cabinets, a granite countertop, stainless steel appliances, and a central island with bar stools.

10. Near Downtown, 3 Bed 3 Bath, 2 EnSuite, FirePit, Fenced Yard Great for Pets

Near Downtown, 3 Bed 3 Bath, 2 EnSuite, FirePit, Fenced Yard Great for Pets
Greenville
10.0 out of 10, Exceptional, (25 reviews)
"Place was very clean. Quiet neighborhood. Great set up with 3 separate suites. Very enjoyable stay. "
United States
Anonymous traveler
Near Downtown, 3 Bed 3 Bath, 2 EnSuite, FirePit, Fenced Yard Great for Pets
A dining area with a wooden table, black chairs, and two abstract paintings on the wall.

11. 2BR Home with Game Room, Near Downtown & Nature

2BR Home with Game Room, Near Downtown & Nature
Greenville
The price is ￥14,105
￥43,378 total
includes taxes & fees
Nov 3 - Nov 4
2BR Home with Game Room, Near Downtown & Nature
A modern living room with a grey sofa, a round coffee table, and a dining area with a table and chairs.

12. Southern Charm Townhome

Southern Charm Townhome
Simpsonville
10.0 out of 10, Exceptional, (11 reviews)
"Very clean and safe location. Super cute interior decorations and comfortable. Also a great location for us to visit family who are local. Absolutely would stay again."
United States
Brianna F.
The price is ￥22,751
￥68,877 total
includes taxes & fees
Nov 1 - Nov 2
Southern Charm Townhome
Living area

13. Historic 3BR with Porch & Fire Pit near Downtown

Historic 3BR with Porch & Fire Pit near Downtown
Simpsonville
9.0 out of 10, Wonderful, (9 reviews)
"Close to town easy walk to dinner"
United States
Gary g.
The price is ￥18,323
￥51,393 total
includes taxes & fees
Nov 3 - Nov 4
Historic 3BR with Porch & Fire Pit near Downtown
Private kitchen

14. Cozy 2-Bedroom Retreat in Serene Greenville – Close to Everything

Cozy 2-Bedroom Retreat in Serene Greenville – Close to Everything
Greenville
10.0 out of 10, Exceptional, (1 review)
"Clean room. Nice location"
United States
Victor B.
Cozy 2-Bedroom Retreat in Serene Greenville – Close to Everything
A two-story building with a stone entrance gate, a sign reading "West End Cottages 20 Howe Street," and a clear blue sky in the background.

15. Reedy River Retreat - Walk to Everything Downtown

Reedy River Retreat - Walk to Everything Downtown
Greenville Downtown
10.0 out of 10, Exceptional, (13 reviews)
"Great locations and very nice place "
United States
annalee j.
The price is ￥39,501
￥79,050 total
includes taxes & fees
Oct 20 - Oct 21
Reedy River Retreat - Walk to Everything Downtown
An outdoor patio with a fire pit, wooden furniture, and string lights.

16. Dog friendly! 8 mins to Downtown • Bike to trails • 10 mins to TR

Dog friendly! 8 mins to Downtown • Bike to trails • 10 mins to TR
Greenville
10.0 out of 10, Exceptional, (17 reviews)
"Wonderful stay at this property! Nice, quiet location, plenty of comfortable space for a family to spread out, very clean, hosts were very responsive. We’d definitely recommend and stay here again! "
United States
Ginger P.
Dog friendly! 8 mins to Downtown • Bike to trails • 10 mins to TR
A laundry room with two front-loading washing machines, a white cabinet above, and a shelf with books.

17. Trailside Hike & Bike Haven - 0.1 Mile from the Swamp Rabbit Trail!

Trailside Hike & Bike Haven - 0.1 Mile from the Swamp Rabbit Trail!
Travelers Rest
10.0 out of 10, Exceptional, (2 reviews)
"This is a great property, especially if you want to be close to the downtown area and the Swamp Rabbit Trail! The home has all the amenities you need for a comfortable stay (and then some). It's very clean and nicely decorated. Communication and check-in/check-out process was easy. Highly recommend."
United States
John
The price is ￥23,905
￥29,952 total
includes taxes & fees
Nov 11 - Nov 12
Trailside Hike & Bike Haven - 0.1 Mile from the Swamp Rabbit Trail!
A living room with a piano, a sofa, and a coffee table.

18. The Jireh House - Speakeasy & Hot Tub 8 mins Downtown GVL

The Jireh House - Speakeasy & Hot Tub 8 mins Downtown GVL
Greenville
10.0 out of 10, Exceptional, (17 reviews)
"It was a great place!"
United States
Eric W.
The price is ￥34,917
￥61,029 total
includes taxes & fees
Oct 14 - Oct 15
The Jireh House - Speakeasy & Hot Tub 8 mins Downtown GVL
A living room with a leather recliner, a fireplace, a flat-screen TV, and a ceiling fan.

19. Quiet house in the country, walking distance to Stewarts fishing pond

Quiet house in the country, walking distance to Stewarts fishing pond
Pelzer
10.0 out of 10, Exceptional, (12 reviews)
"This home was great! Very clean, private, and very accommodating. Highly recommend!"
United States
Amie G.
The price is ￥17,776
￥56,548 total
includes taxes & fees
Oct 14 - Oct 15
Quiet house in the country, walking distance to Stewarts fishing pond
A room with a bed, a small table with stools, a 'Love' sign, and a door.

20. Tigers! Near Clemson.

Tigers! Near Clemson.
Easley
9.6 out of 10, Exceptional, (8 reviews)
"Cute place. Perfect for our stay would definitely recommend."
United States
Renelle H.
The price is ￥15,705
￥39,444 total
includes taxes & fees
Nov 9 - Nov 10
Tigers! Near Clemson.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Upstate South Carolina Hotel Reviews

Hyatt Regency Greenville

Hyatt Regency Greenville

10/10 Excellent
"Such a wonderful stay!!! The hotel was fantastic and in such a great location! The staff was incredibly welcoming, and the bartender downstairs was so much fun! One little moment that really stood out was when it started raining and I mentioned that I wished I had an umbrella. Without hesitation, one of the staff members offered me an extra one he had. It’s those little gestures that make such a difference! Just an all-around amazing experience for my first visit to Greenville! We will definitely be back!"
Natalie 1-night trip
Posted 8 hours ago
Hyatt Regency Greenville

Find out more about Upstate South Carolina

Upstate South Carolina Vacation Homes information

Number of reviews
247
Accommodation
871 Vacation Homes
Lowest Price
￥26,229
Highest Price
￥79,050

Explore a world of travel with Expedia