Find all hotels by Motel 6 in Upstate South Carolina, SC from ¥8,678
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Compare rooms and suites by Motel 6 in Upstate South Carolina with rates, reviews, and availability. Most hotels are fully refundable.

Motel 6 Greenville, SC
Greenville
5.0 out of 10, (672)
The price is ¥7,609
¥8,678 total
includes taxes & fees
Nov 16 - Nov 17

Motel 6 Greenville, SC - I-85 Near Downtown
Greenville
6.8 out of 10, (317)
The price is ¥8,627
¥9,490 total
includes taxes & fees
Nov 16 - Nov 17

Motel 6 Simpsonville, SC - Greenville
Simpsonville
7.4 out of 10, Good, (346)
The price is ¥9,706
¥10,677 total
includes taxes & fees
Nov 15 - Nov 16

Motel 6 Spartanburg, Sc – Northwest / Business 85
Spartanburg
7.2 out of 10, Good, (70)
The price is ¥11,505
¥12,770 total
includes taxes & fees
Nov 14 - Nov 15
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Upstate South Carolina Hotel Reviews

Best Western Plus Greenville I-385 Inn & Suites
10/10 Excellent
Explore a world of travel with Expedia
Upstate South Carolina Hotels by Brand
Hotels in Upstate South Carolina Neighborhoods
- Greenville Downtown Hotels
- West End Hotels
- Green Avenue Hotels
- Pettigru Street Historic District Hotels
- Hampton-Pinckney Historic District Hotels
- Woodside Cotton Mill Village Historic District Hotels
- Colonel Elias Earle Historic District Hotels
- Pine Ridge Point Hotels
- Spartanburg Historic District Hotels
Hotels near popular Upstate South Carolina Attractions
More Accommodation Types in Upstate South Carolina
Explore more hotels
- Woodspring Suites Greenville Airport
- Hyatt Place Greenville Downtown
- Comfort Inn Greenville - Haywood Mall
- Motel 6 Greenville, SC
- ECHO Suites Extended Stay by Wyndham Spartanburg
- Wingate by Wyndham - Greenville-Airport
- Drury Inn & Suites Greenville
- The Shepherd Hotel Downtown Clemson
- Lakeside Lodge Clemson




















