Downtown Clayton, MO
St. Louis
Visit Downtown Clayton
Popular places to visit
St. Louis Union Station
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
Enterprise Center
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.
St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Dome at America’s Center
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and great live music.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
Private Tour of St. Louis's Iconic BBQ Joints & Breweries
St. Louis Premium Small Group Tour With Arch & River Cruise
Lemp Haunted Neighborhood Walking Tour
Downtown St. Louis Smartphone Guided Audio Walking Tour App
Downtown Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
Comfortable. Excellent staff.
Reviewed on Feb 18, 2026
The Ritz-Carlton, St. Louis
Excellent hotel with various restaurants and expansive lobby area.. staff very attentive.
Reviewed on Feb 6, 2026
Le Méridien St. Louis Clayton
Room was beautiful and clean.
Reviewed on Feb 2, 2026
AC Hotel St. Louis Clayton
Front desk staff was excellent. Good service at the bar. Gentleman at the valet desk was inattentive and disappointing - and that was after I tipped him.
Reviewed on Feb 15, 2026
21C Museum Hotel St Louis
Pleasant staff
Reviewed on Feb 17, 2026
Pear Tree Inn St. Louis Airport
We felt very welcome when we arrived and were invited to some popcorn and soda as an evening snack. Our room was spotless and comfortable. The breakfast was delicious, hot, and a terrific way to begin our day of travel.
Reviewed on Feb 17, 2026
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Other neighborhoods around Downtown Clayton
Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
University City
Noted for its shopping and restaurants, there's plenty to explore in University City. Top attractions like Museum of Transportation and Center of Creative Arts are major draws, and you can hop on the metro at Forsyth Station or U City Big Bend Station to see more of the city.
Ladue
The restaurants and churches are a few reasons travelers visit Ladue. Though there aren't many top sights in the neighborhood, you can visit Saint Louis Galleria Mall and St. Louis Art Museum, a few notable attractions nearby.
Dogtown
If you're looking for some top things to see and do in Dogtown and surrounding area, you can visit St. Louis Zoo and St. Louis Art Museum.
The Hill
If you're looking for some top things to see and do in The Hill and surrounding area, you can visit St. Louis Science Center and Missouri Botanical Gardens and Arboretum.
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
