Find Business Hotels in Southern Indiana

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Business Hotels

Our top choices for Southern Indiana business-friendly hotels

Exterior
Holiday Inn Express Corydon by IHG

Holiday Inn Express Corydon by IHG

Holiday Inn Express Corydon by IHG
2.5 star property
Corydon
8.6 out of 10, Excellent, (360)
"Very clean and great staff!"
United States
Donna
The price is ￥13,554
￥15,045 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Holiday Inn Express Corydon by IHG
Exterior
Comfort Inn Madison near Clifty Falls

Comfort Inn Madison near Clifty Falls

Comfort Inn Madison near Clifty Falls
2.5 star property
Madison
8.8 out of 10, Excellent, (662)
"Great stay, clean, and comfy bed!"
United States
cheryl
The price is ￥14,432
￥16,596 total
includes taxes & fees
Dec 21 - Dec 22
Comfort Inn Madison near Clifty Falls
Water park
Fairfield Inn By Marriott Evansville East

Fairfield Inn By Marriott Evansville East

Fairfield Inn By Marriott Evansville East
2.5 star property
Evansville
8.8 out of 10, Excellent, (458)
"Clean rooms friendly staff "
United States
Aleshia
The price is ￥13,110
￥15,076 total
includes taxes & fees
Dec 20 - Dec 21
Fairfield Inn By Marriott Evansville East
2 restaurants, breakfast served
Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
3.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (816)
"Love the hotel and will always stay there when visiting "
United States
Jeremy
The price is ￥14,831
￥17,451 total
includes taxes & fees
Dec 25 - Dec 26
Tempo By Hilton Louisville Downtown Nulu
Lobby
Comfort Inn Ferdinand

Comfort Inn Ferdinand

Comfort Inn Ferdinand
2.5 star property
Ferdinand
8.4 out of 10, Very Good, (602)
"The manager is AMAZING he went out of his way to make sure our stay was awesome can not recommend this place enough!"
United States
Jessica
The price is ￥13,690
￥15,332 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Comfort Inn Ferdinand
Lobby
Drury Inn & Suites Evansville East

Drury Inn & Suites Evansville East

Drury Inn & Suites Evansville East
3.0 star property
Evansville
9.4 out of 10, Exceptional, (1001)
"Great place to stay "
United States
kenny
The price is ￥14,020
￥16,123 total
includes taxes & fees
Dec 14 - Dec 15
Drury Inn & Suites Evansville East
Free daily on-the-go breakfast
Hampton Inn Corydon

Hampton Inn Corydon

Hampton Inn Corydon
2.5 star property
Corydon
8.8 out of 10, Excellent, (601)
"Courteous staff, clean room"
United States
Steven
The price is ￥16,078
￥17,846 total
includes taxes & fees
Dec 18 - Dec 19
Hampton Inn Corydon
Exterior
Belterra Casino Resort

Belterra Casino Resort

Belterra Casino Resort
3.5 star property
Florence
8.6 out of 10, Excellent, (1000)
"Room was clean and the staff was good."
United States
Gary
The price is ￥18,528
￥22,682 total
includes taxes & fees
Dec 14 - Dec 15
Belterra Casino Resort
Lobby
Ramada by Wyndham Sellersburg/Louisville North

Ramada by Wyndham Sellersburg/Louisville North

Ramada by Wyndham Sellersburg/Louisville North
2.5 star property
Sellersburg
8.4 out of 10, Very Good, (1001)
"Clean room, helpful staff, good breakfast "
United States
Jessica
The price is ￥11,256
￥12,719 total
includes taxes & fees
Dec 15 - Dec 16
Ramada by Wyndham Sellersburg/Louisville North
4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (3839)
"Beautiful room and great hospitality. "
United States
Chase
The price is ￥20,767
￥24,435 total
includes taxes & fees
Dec 27 - Dec 28
Galt House Hotel Trademark Collection by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southern Indiana Hotel Reviews

Sheraton Louisville Riverside by Marriott

Sheraton Louisville Riverside by Marriott

10/10 Excellent
"Room clean and staff friendly"
manuel 4-night trip
Posted 2 days ago
Sheraton Louisville Riverside by Marriott

Explore a world of travel with Expedia

Frequently asked questions

How much do business-friendly hotels in Southern Indiana cost?
Business-friendly hotels in Southern Indiana range between ￥12,719 and ￥24,435 per night. This means you can book a property with welcome amenities like workspaces and conference rooms at a price that fits your work budget. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Indiana?
Southern Indiana offers multiple business-friendly hotels with a total average guest review rating of 8.7. Have a work event in Louisville? Residence Inn by Marriott Louisville East/Oxmoor is a 3-stars stay that's highly recommended by corporate travelers and features a barbecue grill and a swimming pool. Another popular pick for a business trip is Hilton Garden Inn Louisville Mall of St. Matthews. Also in Louisville, it has a 3-stars rating and conveniences such as an electric car charging station and a terrace.
How many business-friendly hotels are there in Southern Indiana?
When your next meeting or conference takes you someplace in Southern Indiana, you'll have 132 business-friendly hotels to pick from.
What are the best cheap business-friendly hotels in Southern Indiana?
When work is taking you out of town in Southern Indiana, Expedia will help you find the perfect business-friendly hotel. Holiday Inn Express & Suites Louisville Downtown, an IHG Hotel is a sought-after budget option in Louisville. Hypo-allergenic bedding and an electric car charging station are among its many amenities. Seeking affordable stays in Evansville? Hampton Inn Evansville/Airport is the first choice for many corporate guests. It has conveniences that make it easy to both work and feel at home, such as pillow top mattresses and a swimming pool. Business-friendly hotels in Southern Indiana start at only ￥12,719 a night. There are tons of fabulous and free things to do wherever you're visiting in Southern Indiana. If your business trip is taking you to Louisville, try to find time in your schedule for Louisville Waterfront Park. You can also see the sights without spending a penny in Evansville. Bally's Evansville Casino is a popular free thing to do here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the top business-friendly motels in Southern Indiana?
Welcoming and affordable, motels are an ideal choice for your next business trip in Southern Indiana. If your job is taking you to Louisville, check out Days Inn by Wyndham Louisville Airport Fair and Expo Center. It's around 11 kilometers south of the downtown area and includes amenities like individually decorated rooms and WiFi. Super 8 by Wyndham Louisville Airport also caters to the needs of corporate travelers. It has a nearby casino and WiFi and is located about 10 kilometers south of the center of Louisville.Looking for epic things to do during your spare time in Louisville? Louisville Slugger Museum and Kentucky Kingdom are just two of the enticing attractions that'll capture your imagination.
Are there any family-friendly hotels in Southern Indiana that are also business friendly?
Absolutely. You'll find some great family-friendly hotels that are also business friendly in Southern Indiana. If you're traveling to Louisville, look up Residence Inn by Marriott Louisville East/Oxmoor. It includes amenities like complimentary breakfast and a barbecue grill and has a 3-stars rating. Another option worth considering is Hilton Garden Inn Louisville Mall of St. Matthews. This 3-stars stay in Louisville is ideal for both leisure and business travelers and features WiFi, laundry facilities and plenty more. You'll discover plenty of awesome things to do with your team in Louisville. Louisville Slugger Museum and Kentucky Kingdom deliver a great day out.
Are there any 5-star business-friendly hotels in Southern Indiana?
While there aren't any 5-star business-friendly hotels in Southern Indiana, there's still a selection of stylish properties to choose from. Visiting Louisville for work? Hotel Distil, Autograph Collection is a popular option that has everything you need and more when you're on a business trip. Amenities at this 4-star property include pillow top mattresses and dining romance packages. Omni Louisville Hotel is another great pick that caters to corporate guests in Louisville. Also with a 4-star rating and featuring spa facilities and massage services, you'll find plenty to love about this hotel.
Why book your business-friendly hotel in Southern Indiana with Expedia?
Expedia is here to help you find an ideal business-friendly hotel for your upcoming work trip. From conference spaces and room service to on-site cafés and more, our stays have all the amenities you'll need to get the job done.
How can I find cheap business-friendly hotels in Southern Indiana?
Select the "business friendly" filter, located under the "traveler experience" heading, to find cheap business-friendly hotels in Southern Indiana. Then narrow your search by your per-night budget. Choosing a stay away from the center is another way to save.
What is there to do in Southern Indiana near my business-friendly hotel?
One of the most important travel accessories for your Southern Indiana business visit is a well-thought-out itinerary for when you have some free time! Louisville Slugger Museum, Louisville Waterfront Park and Louisville Palace are some of the most popular sights if you're making your way to Louisville. Evansville also offers lots of impressive attractions, such as Mesker Park Zoo, Evansville Museum of Arts, History & Science and Koch Family Children's Museum of Evansville.