Southern Indiana Vacations

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Where to stay in Southern Indiana

Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
Louisville Science Center featuring outdoor art

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Find hotels in West Main Historic District

Find the Best Southern Indiana Vacation Packages

Southern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Fully refundableReserve now, pay when you stay
The price is ￥9,236 per night from Jan 13 to Jan 14
￥9,236
￥10,437 total
Jan 13 - Jan 14
includes taxes & fees
6.8/10 (2,713 reviews)
The customer service was excellent she was very understanding of what was going on in my family and I felt like she made it very manageable for me. Thanks for all you done!!!

Reviewed on Jan 6, 2026

Radisson Hotel Louisville North
Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

2.5 out of 5
411 W Spring Street New Albany IN
Fully refundableReserve now, pay when you stay
The price is ￥14,889 per night from Feb 5 to Feb 6
￥14,889
￥16,825 total
Feb 5 - Feb 6
includes taxes & fees
8.8/10 Excellent! (748 reviews)
Didn’t get to get breakfast I slept straight through it. Rooms very clean staff was great

Reviewed on Jan 1, 2026

Hampton Inn New Albany Louisville West
Bally’s Evansville Casino & Hotel

Bally’s Evansville Casino & Hotel

3 out of 5
421 NW Riverside Drive Evansville IN
Fully refundableReserve now, pay when you stay
The price is ￥10,390 per night from Jan 19 to Jan 20
￥10,390
￥15,579 total
Jan 19 - Jan 20
includes taxes & fees
7.6/10 Good! (1,271 reviews)
Room was great, atmosphere was even better and the Entice Band was awesome

Reviewed on Jan 5, 2026

Bally’s Evansville Casino & Hotel
See all 1,629 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southern Indiana

Louisville Slugger Museum showing interior views

Louisville Slugger Museum

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

Louisville Slugger Museum
Muhammad Ali Center featuring modern architecture and night scenes

Muhammad Ali Center

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

Muhammad Ali Center
Helped celebrate the Belle of Louisville's 100th birthday with a cruise up the Ohio River.

Louisville Waterfront Park

After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its lively festivals.

Louisville Waterfront Park

Frequently asked questions

Can I cancel my flight booking to Southern Indiana due to COVID-19?
Our handy Customer Service Portal is your one-stop shop for almost every travel question, including about flight changes and cancellations due to COVID-19. For more peace of mind, look over the terms and conditions of your fare before reserving a seat.
What's the best way to find cheap flights to Southern Indiana that have flexible change policies?
At Expedia, we've been channeling our inner yoga master to get you the most flexible fares around town. Simply check the "No change fee" box right underneath the "Flexible change policies" heading to find your perfect flight to Southern Indiana.
What are some of the general tips for travelers to Southern Indiana during the COVID-19 outbreak?
If it's your first time traveling during the COVID-19 pandemic, you'll notice a raft of new standards and rules in place. Take note of these tips and make your escape to Southern Indiana a smooth one:
  • Find out if any travel restrictions apply to your origin and destination before locking in a flight. Also check if there are any requirements you'll have to follow on arrival, such as proof of a negative COVID-19 test.
  • Keep your face mask on during airport screening. A TSA officer will require you to lower your mask temporarily for ID purposes.
  • To reduce the possibility of cross-contamination, position your boarding pass on the scanner yourself and then hold it up for inspection. Do not hand your boarding pass directly to a TSA employee.
  • One container of liquid hand sanitizer is now allowed in your carry-on luggage. It must be no larger than 12 oz (350 ml), and you'll have to remove it from your bag for scanning.
  • To reduce handling during the screening process, put items such as your belt, phone and wallet into your carry-on instead of the bins.
  • If you're planning to take food on board, place it in a clear plastic bag and then into a scanning bin. This reduces the likelihood that a TSA officer will need to handle your food container or carry-on bag for closer inspection.

Which airlines fly to Southern Indiana?
Let Delta take you there. This leading carrier schedules 121 flights per month to Evansville Regional Airport (EVV), a Southern Indiana gateway.
How can I find cheap tickets to Southern Indiana?
Start searching as early as possible, fly in or out of nearby airports, use miles or points — there's no shortage of ways! One more is to use Expedia's "flexible dates" function. Find your Southern Indiana flight, then compare the prices for nearby dates. In the last seven days, the best price for a flight to Southern Indiana was .
How much is a flight to Southern Indiana?
There were a lot of cheap fares up for grabs in the last seven days, with the price of a return ticket to Southern Indiana varying between and . Many lucky vacationers purchased one-way flights from () for as low as .
What are the most popular airports to fly into in Southern Indiana?
Jet into Evansville Regional Airport (EVV) and experience all that Southern Indiana has to offer. As the region's primary entry point, roughly 381 flights land here every month.
When is the cheapest time to fly to Southern Indiana?
If you'd prefer to spend your vacation cash on having fun in Southern Indiana rather than on getting there, leave early in the week. The most economical day to travel is normally Tuesday, with Monday a close second. With many people traveling over the weekend, Saturday often has the costliest fares.
How much is a plane ticket to Southern Indiana?
Seats to Southern Indiana ranged from to in the last seven days. Usually, the sooner you make a reservation, the bigger the bargain.
Which airlines with flights to Southern Indiana employ COVID-19 cleanliness policies?
In response to the current pandemic, the majority of airlines have rolled out additional steps and actions to help everybody get back in the air. Here's what these carriers are doing:
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.