Southern Indiana Vacations

Book a Hotel + Flight or Car together to unlock savings

    deals illustration
    Better together
    Save up to ￥45,448 when you book a flight and hotel together*
    stays illustration
    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
    luggage illustration
    Rest easy
    Plan, book, and manage your trip all in one place

Where to stay in Southern Indiana

Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
Louisville Science Center featuring outdoor art

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Find hotels in West Main Historic District

Find the Best Southern Indiana Vacation Packages

Southern Indiana Hotel Deals

Radisson Hotel Louisville North
Radisson Hotel Louisville North
3 out of 5
505 Marriott Drive, Clarksville, IN
Fully refundable
The price is ￥9,674 per night from Jun 22 to Jun 23
￥9,674
￥10,931 total
Jun 22 - Jun 23
includes taxes & fees
6.8/10 (2,128 reviews)
"Nice service and clean and quiet room"

Reviewed on Jun 13, 2025

Radisson Hotel Louisville North
Hampton Inn Evansville
Hampton Inn Evansville
3 out of 5
8000 Eagle Crest Boulevard, Evansville, IN
Fully refundableReserve now, pay when you stay
The price is ￥9,232 per night from Jul 13 to Jul 14
￥9,232
￥10,617 total
Jul 13 - Jul 14
includes taxes & fees
8.6/10 Excellent! (1,001 reviews)
"Room was clean. Nice pool for the kids. Staff was friendly."

Reviewed on Jun 11, 2025

Hampton Inn Evansville
Bally’s Evansville Casino & Hotel
Bally’s Evansville Casino & Hotel
3 out of 5
421 NW Riverside Drive, Evansville, IN
Fully refundableReserve now, pay when you stay
The price is ￥18,585 per night from Jun 20 to Jun 21
￥18,585
￥24,685 total
Jun 20 - Jun 21
includes taxes & fees
7.6/10 Good! (1,177 reviews)
"N/a"

Reviewed on Jun 12, 2025

Bally’s Evansville Casino & Hotel
See all 1,410 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Southern Indiana vacation package cost?
We make it simple to travel somewhere new, with Southern Indiana vacation packages starting from just . You’ll have the flexibility to combine your preferred airlines, hotels and car rental. For the ultimate escape, why not add a few activities and tours to your itinerary?
How do I get a cheap travel package to Southern Indiana?
If you love bargains, combine your bookings into a Southern Indiana vacation package. Whether you’re looking for flights, hotels, day tours or rental cars, you can book everything in one place. You’ll have plenty of choice at your fingertips too. Expedia has over 550 airlines and 1,000,000 hotels around the globe to take your pick of. Fly with who you want, stay where you like and save a packet — now that’s the ideal getaway!
Where should I stay in Southern Indiana?
Louisville is a fantastic place to explore. It draws in many travelers who come to see its top sights, like Churchill Downs and Muhammad Ali Center.
What are the top hotels in Southern Indiana?
When it comes to properties in Louisville, Galt House Hotel Trademark Collection by Wyndham and Radisson Hotel Louisville Jeffersonville are two fantastic options. If you’re also spending time in Jeffersonville - Clarksville, Radisson Hotel Louisville Jeffersonville and JW Marriott Indianapolis look forward to welcoming you.
How far in advance should I book my Southern Indiana vacation?
It all depends on the airline, but you can normally browse through international airfares on Expedia up to a year in advance. While it’s a good idea to book ahead of time, lucky travelers will sometimes score a cheaper seat only weeks before the date of departure.
What does an Expedia Southern Indiana travel package include?
With Expedia, you can select any combination of flights, car rentals and hotels to create your ideal Southern Indiana travel package. Once you’ve made your booking, you can add on all the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the greater the savings!
What should I know before booking a Southern Indiana travel package?
You’ll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fabulous discounts. Hotels aren’t your only choice, though. Book with us and select from island resorts, rural cottages and everything in between!
Can I choose my airline with a Southern Indiana Expedia vacation package?
Expedia offers access to more than 550 partner airlines globally, so you certainly can. Simply select the carrier that suits you and create the perfect Southern Indiana trip.
If I'm not able to travel, can I cancel my Southern Indiana vacation package?
Yes, you can. We understand that even the best-laid plans can go awry, so we’re here to help if you have to make changes to your Southern Indiana vacation package. You may be able to amend or cancel your itinerary at no cost if you’ve booked in the last 24 hours. Your hotel, airline or car rental company may impose a fee if your booking was made more than 24 hours ago. Have a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.

Discover the most popular places to visit in Southern Indiana

Louisville Slugger Museum showing interior views

Louisville Slugger Museum

4.5/5(606 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

Louisville Slugger Museum
Helped celebrate the Belle of Louisville's 100th birthday with a cruise up the Ohio River.

Louisville Waterfront Park

4.5/5(301 reviews)

After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its great live music.

Louisville Waterfront Park
Muhammad Ali Center featuring modern architecture and night scenes

Muhammad Ali Center

4.5/5(243 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

Muhammad Ali Center

What to do in Southern Indiana

Evansville Multi Attraction Pass

Evansville Multi Attraction Pass

￥3,699
per adult
Evansville Multi Attraction Pass
See all activities in Southern Indiana
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.