Find hotels near Sanford USD Medical Center, Sioux Falls from ￥9,037

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 25 - Dec 26
Tomorrow
Dec 26 - Dec 27
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanford USD Medical Center hotels

Terrace/patio
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
University Heights, 0.1 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (586)
"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "
United States
Tracey
The price is ￥15,728
￥17,567 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
Interior detail
Hotel On Phillips

Hotel On Phillips

Hotel On Phillips
2.5 star property
Downtown Sioux Falls, 1.8 km from Sanford USD Medical Center
9.6 out of 10, Exceptional, (1304)
"Great staff and location!"
United States
Gerald
Hotel On Phillips
Free daily continental breakfast
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls
3.0 star property
Mall District, 2.9 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (1000)
"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "
United States
Rosario
Clubhouse Hotel Suites Sioux Falls
Meeting facility
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown
4.0 star property
Downtown Sioux Falls, 2.4 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (159)
"Room was very clean, great overall stay."
United States
Destiny
The price is ￥20,331
￥23,238 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Canopy By Hilton Sioux Falls Downtown
Presidential Suite, 1 King Bed, Jetted Tub (Balcony) | Living area | 42-inch LCD TV with cable channels, TV, pay movies
Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown
3.0 star property
Downtown Sioux Falls, 2 km from Sanford USD Medical Center
9.0 out of 10, Wonderful, (889)
"Friendly front desk staff, clean room, great location, safe "
United States
Hannah
The price is ￥16,223
￥18,734 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hilton Garden Inn Sioux Falls Downtown
Exterior
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG
3.0 star property
Downtown Sioux Falls, 1.8 km from Sanford USD Medical Center
8.6 out of 10, Excellent, (1000)
"Always a great stay. "
United States
Shawn
The price is ￥16,062
￥17,933 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Sioux Falls-City Centre by IHG
Porch
Historic Victorian Inn

Historic Victorian Inn

Historic Victorian Inn
3.0 star property
Cathedral, 1.4 km from Sanford USD Medical Center
8.8 out of 10, Excellent, (56)
"It was a great place to stay and super interesting."
United States
Kathy
The price is ￥21,173
￥25,783 total
includes taxes & fees
Dec 27 - Dec 28
Historic Victorian Inn
Exterior
Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls
3.0 star property
Downtown Sioux Falls, 1.9 km from Sanford USD Medical Center
8.4 out of 10, Very Good, (1161)
"It was a great place to stay!"
United States
Trinity
The price is ￥13,047
￥14,625 total
includes taxes & fees
Dec 29 - Dec 30
Country Inn & Suites by Radisson, Sioux Falls
Lobby
Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center
4.0 star property
Northwest Sioux Falls, 2.8 km from Sanford USD Medical Center
8.6 out of 10, Excellent, (1000)
"Great hotel. Staff was excellent "
United States
Kristina
The price is ￥16,436
￥18,342 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Sheraton Sioux Falls Hotel & Convention Center
Free daily continental breakfast
The Center Inn

The Center Inn

The Center Inn
2.5 star property
All Saints, 2.3 km from Sanford USD Medical Center
8.4 out of 10, Very Good, (703)
"Room and staff were great. "
United States
Annette
The Center Inn
Room, 2 Queen Beds | Desk, free WiFi, wheelchair access
Valley Inn

Valley Inn

Valley Inn
2.5 star property
University Heights, 0.1 km from Sanford USD Medical Center
7.6 out of 10, Good, (1000)
"Room was clean, staff was friendly, very convenient location "
United States
Theresa
Valley Inn
3 indoor pools, open 9:00 AM to 10:00 PM, sun loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls, 2.9 km from Sanford USD Medical Center
7.8 out of 10, Good, (1458)
"staff was friendly "
United States
Rob
The price is ￥10,018
￥11,300 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Dining room
Historic Twin Tudors Inn

Historic Twin Tudors Inn

Historic Twin Tudors Inn
3.0 star property
1.3 km from Sanford USD Medical Center
8.8 out of 10, Excellent, (3)
"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "
United States
Anonymous traveler
The price is ￥41,963
￥47,585 total
includes taxes & fees
Dec 29 - Dec 30
Historic Twin Tudors Inn
Pool
Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites
2.0 star property
Northwest Sioux Falls, 2.9 km from Sanford USD Medical Center
7.0 out of 10, Good, (52)
"Very friendly at check in. Great service at bar."
United States
Chris
Ramada by Wyndham Sioux Falls Arpt & Suites
Lobby
Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls
2.0 star property
2.7 km from Sanford USD Medical Center
5.6 out of 10, (1000)
"Good room for the price."
United States
Michael
The price is ￥7,953
￥9,037 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Ramada by Wyndham Sioux Falls
Terrace/patio
Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South
3.0 star property
Mall District, 3.8 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (1000)
"Great stay!"
United States
Nick
The price is ￥18,245
￥20,328 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hyatt Place Sioux Falls South
Exterior
Holiday Inn & Suites Sioux Falls - Airport by IHG

Holiday Inn & Suites Sioux Falls - Airport by IHG

Holiday Inn & Suites Sioux Falls - Airport by IHG
3.0 star property
Northwest Sioux Falls, 3.3 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (844)
"Was the perfect place to stay for late arrival into airport. Nothing fancy but met expectations and there was a restaurant next door that you can walk to. "
United States
Joshua
The price is ￥15,438
￥17,248 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn & Suites Sioux Falls - Airport by IHG
Exterior
Candlewood Suites Sioux Falls by IHG

Candlewood Suites Sioux Falls by IHG

Candlewood Suites Sioux Falls by IHG
2.5 star property
Mall District, 3.5 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (678)
"clean, great friendly staff "
United States
Morgan
The price is ￥15,438
￥17,247 total
includes taxes & fees
Dec 29 - Dec 30
Candlewood Suites Sioux Falls by IHG
Exterior
Staybridge Suites Sioux Falls by IHG

Staybridge Suites Sioux Falls by IHG

Staybridge Suites Sioux Falls by IHG
3.0 star property
Mall District, 3.3 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (1003)
"Friendly, clean, easy check in even with pet"
United States
Susan
The price is ￥15,126
￥16,906 total
includes taxes & fees
Dec 28 - Dec 29
Staybridge Suites Sioux Falls by IHG
Exterior
La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls
3.0 star property
Mall District, 4.1 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (1552)
"Room was clean and comfortable. "
United States
Alan
The price is ￥12,182
￥13,675 total
includes taxes & fees
Dec 28 - Dec 29
La Quinta Inn & Suites by Wyndham Sioux Falls
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sanford USD Medical Center Hotel Reviews

AeroStay Hotel

AeroStay Hotel

10/10 Excellent
"VERY CLEAN ROOM, FRIENDLY AND HELPFUL STAFF, ADEQUATE BREAKFAST"
DUANE 1-night trip
Posted 2 days ago
AeroStay Hotel

Hotels near other Sanford USD Medical Center attractions

Sioux Empire Medical Museum

You can spend time studying the exhibits at Sioux Empire Medical Museum in Sioux Falls. In the area, take in the entertainment choices and beautiful waterfalls.
See properties

University of Sioux Falls

4.1/5 (170 reviews)
Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
See properties

Frequently asked questions

What's the area like around Sanford USD Medical Center?
Sanford USD Medical Center is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 110 hotels and other accommodations you'll find within a mile.
Where is the best place to stay close to Sanford USD Medical Center?
Adjacent to Sanford USD Medical Center, Home2 Suites By Hilton Sioux Falls/Sanford Medical Center is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. Another good choice is Valley Inn, located just 0.1 mi (0.1 km) away.
How many hotels should I expect to find close to Sanford USD Medical Center?
Expedia has 110 hotels and other accommodations within a mile from Sanford USD Medical Center.
If I need to cancel the hotel reservation for my stay near Sanford USD Medical Center, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to get the best deals available near Sanford USD Medical Center.
Where can I learn more about changing or cancelling my trip in the area near Sanford USD Medical Center?
To find more details about updating your stay near Sanford USD Medical Center or cancelling it, go to https://www.expedia.com/service/.
What can I see and do near Sanford USD Medical Center?
Study the collections at Washington Pavilion of Arts and Science, Center for Western Studies, or Old Courthouse Museum. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. Local parks like Falls Park, Fawick Park, and Sherman Park are peaceful spots to stop and take in some fresh air.