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Discover 12,842 Mayo Clinic hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Sonesta Select Scottsdale at Mayo Clinic Campus
Relax in a serene space with a seating area, bench, and wall-mounted light fixture.

Sonesta Select Scottsdale at Mayo Clinic Campus

3.0 star property
8.2 out of 10, Very Good, (1009)
"Perfect for a quiet getaways and small views. "
The price is ￥11,172
￥12,732 total
includes taxes & fees
Aug 6 - Aug 7
Sonesta Select Scottsdale at Mayo Clinic Campus
Wekopa Casino Resort
Relax and socialize in this inviting patio area, featuring a central fire pit and comfortable seating under a shaded pergola.

Wekopa Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1000)
"Great stay!!"
Wekopa Casino Resort
Fountain Park Hotel, BW Signature Collection
Spacious room with a high ceiling and large windows, featuring an island and comfortable seating area.

Fountain Park Hotel, BW Signature Collection

3.0 star property
8.8 out of 10, Excellent, (1001)
"Very nice hotel and reasonable in price "
The price is ￥12,475
￥14,244 total
includes taxes & fees
Jul 30 - Jul 31
Fountain Park Hotel, BW Signature Collection
Westgate Painted Mountain Golf Resort
Stroll through the beautifully maintained garden, featuring a variety of plants and a striking red-flowered bush, surrounded by a classical building with a red roof and arched design.

Westgate Painted Mountain Golf Resort

4.0 star property
8.4 out of 10, Very Good, (1006)
"Great location and amenities—stayed there twice now."
The price is ￥12,699
￥14,510 total
includes taxes & fees
Jul 30 - Jul 31
Westgate Painted Mountain Golf Resort
Best Western Superstition Springs Inn
Two single beds with crisp linens, a flat-screen TV, and a desk with a lamp.

Best Western Superstition Springs Inn

2.5 star property
7.8 out of 10, Good, (933)
"Awesome place "
The price is ￥12,475
￥14,255 total
includes taxes & fees
Jul 30 - Jul 31
Best Western Superstition Springs Inn
Country Inn & Suites by Radisson, Mesa, AZ
Relax in our spacious lobby, featuring a reception desk, comfortable seating areas, and a warm atmosphere.

Country Inn & Suites by Radisson, Mesa, AZ

2.5 star property
7.8 out of 10, Good, (1001)
"The safest place to sleep in my opinion "
The price is ￥13,128
￥15,003 total
includes taxes & fees
Aug 5 - Aug 6
Country Inn & Suites by Radisson, Mesa, AZ
SureStay Plus by Best Western Mesa Superstition Springs
Experience the welcoming entrance of this hotel, marked by a covered walkway and illuminated main doors.

SureStay Plus by Best Western Mesa Superstition Springs

2.5 star property
8.4 out of 10, Very Good, (1525)
"Very clean and great location"
The price is ￥10,191
￥11,645 total
includes taxes & fees
Aug 14 - Aug 15
SureStay Plus by Best Western Mesa Superstition Springs
La Quinta Inn & Suites by Wyndham Mesa Superstition Springs
Stroll through the serene courtyard, surrounded by lush landscaping and a central gazebo with a table and chairs.

La Quinta Inn & Suites by Wyndham Mesa Superstition Springs

3.0 star property
8.2 out of 10, Very Good, (1692)
"Great spot to stay"
The price is ￥11,361
￥12,982 total
includes taxes & fees
Jul 31 - Aug 1
La Quinta Inn & Suites by Wyndham Mesa Superstition Springs
Inn at Eagle Mountain
Situated on a hillside overlooking a serene body of water, this property offers a tranquil desert landscape with a mix of flat and sloped roofs.

Inn at Eagle Mountain

3.5 star property
8.8 out of 10, Excellent, (1000)
"Very nice location, friendly staff, and perfect for our family. "
Inn at Eagle Mountain
Superior Suites Phoenix Mesa
Welcome to our lobby, featuring a reception desk, seating area, and a map of the United States on the wall.

Superior Suites Phoenix Mesa

2.0 star property
7.0 out of 10, Good, (1007)
"Surprised at this property, it was really nice. Definitely motel vibes and older, but well maintained. "
The price is ￥8,714
￥10,548 total
includes taxes & fees
Aug 22 - Aug 23
Superior Suites Phoenix Mesa
The Azure Hotel
Experience a warm welcome in our inviting lobby, featuring a reception desk, comfortable seating, and a unique light fixture.

The Azure Hotel

2.5 star property
8.8 out of 10, Excellent, (1483)
"The staff were excellent and rooms are clean. I definitely will stay there again when I visit "
The Azure Hotel
Hilton Vacation Club Scottsdale Links Resort
Stylish residential building with a symmetrical facade and beautifully maintained gardens.

Hilton Vacation Club Scottsdale Links Resort

3.5 star property
9.2 out of 10, Wonderful, (1014)
"Love staying here! "
The price is ￥14,060
￥20,403 total
includes taxes & fees
Aug 13 - Aug 14
Hilton Vacation Club Scottsdale Links Resort
Talking Stick Resort
Relax by the pool surrounded by comfortable lounge chairs and umbrellas.

Talking Stick Resort

4.0 star property
9.2 out of 10, Wonderful, (3616)
"Great resort!!"
The price is ￥16,596
￥23,157 total
includes taxes & fees
Aug 6 - Aug 7
Talking Stick Resort
Aiden by Best Western Scottsdale North
Relax by the pool surrounded by comfortable lounge chairs and a seating area.

Aiden by Best Western Scottsdale North

3.0 star property
9.0 out of 10, Wonderful, (1007)
"Clean and staff was friendly "
The price is ￥12,433
￥14,170 total
includes taxes & fees
Jul 31 - Aug 1
Aiden by Best Western Scottsdale North
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
Relax in a serene outdoor space surrounded by mature palm trees and a classic gazebo.

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

3.0 star property
8.8 out of 10, Excellent, (1626)
"Super fast check in and great staff."
The price is ￥11,786
￥13,432 total
includes taxes & fees
Aug 2 - Aug 3
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
Sheraton Desert Oasis Villas, Scottsdale
Relax by the pool surrounded by palm trees and a scenic waterfall.

Sheraton Desert Oasis Villas, Scottsdale

3.5 star property
9.2 out of 10, Wonderful, (891)
"Great place to stay!"
The price is ￥18,757
￥21,377 total
includes taxes & fees
Aug 22 - Aug 23
Sheraton Desert Oasis Villas, Scottsdale
Days Inn & Suites by Wyndham Mesa Near Phoenix
Relax in a stylish room with two single beds, a large window offering a view of the outdoors, and a desk for work or relaxation.

Days Inn & Suites by Wyndham Mesa Near Phoenix

3.0 star property
9.0 out of 10, Wonderful, (1759)
"This is our go to hotel everytime we visit Meza."
The price is ￥10,225
￥11,684 total
includes taxes & fees
Jul 31 - Aug 1
Days Inn & Suites by Wyndham Mesa Near Phoenix
Comfort Suites Scottsdale Talking Stick Entertainment District
Relax in the hotel lobby with a cozy fireplace, comfortable seating, and a flat-screen TV.

Comfort Suites Scottsdale Talking Stick Entertainment District

2.5 star property
9.2 out of 10, Wonderful, (1622)
"Very nice hotel "
The price is ￥10,982
￥12,520 total
includes taxes & fees
Aug 5 - Aug 6
Comfort Suites Scottsdale Talking Stick Entertainment District
Hilton Vacation Club Scottsdale Villa Mirage
Relax by the serene pool, featuring a gentle waterfall and sun loungers.

Hilton Vacation Club Scottsdale Villa Mirage

3.5 star property
8.4 out of 10, Very Good, (1007)
"It was a beautiful place to stay even for a day."
The price is ￥10,574
￥16,459 total
includes taxes & fees
Aug 19 - Aug 20
Hilton Vacation Club Scottsdale Villa Mirage
Holiday Inn Club Vacations Scottsdale Resort by IHG
Relax by the serene pool surrounded by lush palm trees and a soothing waterfall.

Holiday Inn Club Vacations Scottsdale Resort by IHG

4.0 star property
9.0 out of 10, Wonderful, (1001)
"Our family loved everything about this hotel, wonderful!"
The price is ￥16,269
￥23,422 total
includes taxes & fees
Aug 14 - Aug 15
Holiday Inn Club Vacations Scottsdale Resort by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most.
Downtown Phoenix which includes signage and night scenes
Downtown Phoenix map

Downtown Phoenix

3 out of top 10 points of interest in this area

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

Old Town
Old Town map

Old Town

Old Town is known for its popular shops, and you can see some sights in the area like Scottsdale Waterfront and Western Spirit: Scottsdale's Museum of the West.

Papago Park featuring desert views as well as a small group of people
Camelback East map

Camelback East

2 out of top 10 points of interest in this area

Adjacent to Paradise Valley and Scottsdale, Camelback East Village boasts two main cores and sits between Piestewa Peak and Camelback Mountain. Explore the vibrant 24th Street and Camelback Road or 44th Street and Van Buren Street areas.

East Mesa map

East Mesa

While you're in East Mesa, take in top sights like Salt River Tubing and jump on the metro at Superstition Springs Transit Center to see more of the city.

Central Scottsdale map

Central Scottsdale

1 out of top 10 points of interest in this area

While visiting Central Scottsdale, you might make a stop by sights like Scottsdale Ranch Park and Starfire Golf Club at Scottsdale Country Club.

Top Mayo Clinic Hotel Reviews

Canopy by Hilton Scottsdale Old Town

Canopy by Hilton Scottsdale Old Town

10/10 Excellent
"We enjoyed our stay and had no issues, thank you!"
Hassan 4-night trip
Posted 10 hours ago
Canopy by Hilton Scottsdale Old Town

Frequently asked questions

What is Mayo Clinic like?

Travelers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighborhood.

Where is the best place to stay in Mayo Clinic?

Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.

How many hotels will I be able to find in the Mayo Clinic area?

With 14 Expedia hotels and other accommodations in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.

If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?

Yes! Most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in Mayo Clinic.

Where can I learn more about changing or cancelling my trip to Mayo Clinic?

For more information about updating your trip to Mayo Clinic or cancelling it, go to https://www.expedia.com/service/.

What is there to do around this Scottsdale neighborhood?

A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain, and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.