Find Resorts & Hotels with Spas in Lower Keys, FL

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Lower Keys Resorts & Hotels with Spas

Our top choices for Lower Keys hotels with a spa

Ocean Key Resort - A Noble House Resort

Ocean Key Resort - A Noble House Resort
4.0 star property
Key West Historic District
9.2 out of 10, Wonderful, (1,002 reviews)
  • cleanliness
    Waterfront resort spa with exotic massage options and ocean views offers full-service relaxation by the Key West sunset.
The price is ¥41,523
¥59,036 total
includes taxes & fees
Jun 7 - Jun 8
Ocean Key Resort - A Noble House Resort

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,155 reviews)
  • cleanliness
    Restore serenity at this beachfront hotel with 5 tranquil spa treatment rooms and multiple outdoor pools overlooking stunning ocean views.
The price is ¥40,074
¥54,828 total
includes taxes & fees
May 19 - May 20
Isla Bella Beach Resort & Spa

Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton
4.0 star property
Old Town Key West
8.4 out of 10, Very Good, (660 reviews)
  • cleanliness
    Beach resort with spa offering aromatherapy, Ayurvedic treatments, and beachside massages for ultimate relaxation.
The price is ¥41,426
¥57,320 total
includes taxes & fees
Jun 5 - Jun 6
Casa Marina Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton
4.0 star property
Old Town Key West
8.6 out of 10, Excellent, (1,007 reviews)
  • cleanliness
    Luxurious beachfront spa retreat offers deep-tissue massages and serene outdoor treatments in Key West.
The price is ¥31,942
¥46,650 total
includes taxes & fees
May 26 - May 27
The Reach Key West, Curio Collection by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,170 reviews)
  • cleanliness
    Rejuvenate at this waterfront resort's luxurious Ocean Spa with specialized massages in serene rooms.
The price is ¥29,565
¥39,233 total
includes taxes & fees
Jun 14 - Jun 15
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa
4.0 star property
Key West Historic District
9.0 out of 10, Wonderful, (1,015 reviews)
  • cleanliness
    Luxurious oceanfront escape with 3 spa treatment rooms offers deep-tissue massages, facials, and holistic therapies for pure rejuvenation.
The price is ¥37,145
¥52,860 total
includes taxes & fees
May 25 - May 26
Hyatt Centric Key West Resort and Spa

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses
4.0 star property
Old Town Key West
8.8 out of 10, Excellent, (3,326 reviews)
  • cleanliness
    Serene beachside spa oasis offers tropical relaxation with ocean views and couples treatments.
The price is ¥35,807
¥51,891 total
includes taxes & fees
Jun 4 - Jun 5
Southernmost Beach Resort and Guesthouses

Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West
4.0 star property
Old Town Key West
9.2 out of 10, Wonderful, (1,101 reviews)
  • cleanliness
    Indulge in oceanfront spa retreats with sunset views at this tropical Key West haven just steps from Duval Street.
The price is ¥41,114
¥52,505 total
includes taxes & fees
May 25 - May 26
Opal Key Resort & Marina, Key West

Pier House Resort & Spa

Pier House Resort & Spa
4.0 star property
Key West Historic District
9.0 out of 10, Wonderful, (1,125 reviews)
  • cleanliness
    Waterfront spa resort invites relaxation with private beach, outdoor pool, and rejuvenating treatments in Key West's central locale.
The price is ¥45,603
¥62,375 total
includes taxes & fees
May 25 - May 26
Pier House Resort & Spa

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,009 reviews)
  • cleanliness
    Rejuvenate your spirit at this waterfront sanctuary where serene spa treatments complement 3 sparkling pools.
The price is ¥48,432
¥64,853 total
includes taxes & fees
Jun 14 - Jun 15
Tranquility Bay Beachfront Hotel and Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Lower Keys

Top Lower Keys Hotel Reviews

Explore a world of travel with Expedia