Photo by T McD

Find hotels in Illinois Medical District, Chicago from ￥16,044

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 5 - Sep 6
Tomorrow
Sep 6 - Sep 7
This weekend
Sep 5 - Sep 7
Next weekend
Sep 12 - Sep 14

Filter by

Guest rating
Guest rating
Star rating

Discover 4,625 Illinois Medical District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for Illinois Medical District hotels

FOUND Hotel Chicago River North
Exterior

FOUND Hotel Chicago River North

2.0 star property
8.2 out of 10, Very Good, (225)
"Great place "
The price is ￥17,644
￥20,712 total
includes taxes & fees
Sep 24 - Sep 25
FOUND Hotel Chicago River North
Ohio House Motel
Reception

Ohio House Motel

3.0 star property
9.0 out of 10, Wonderful, (1001)
"Awesome place to stay. "
The price is ￥17,638
￥20,705 total
includes taxes & fees
Sep 22 - Sep 23
Ohio House Motel
Level Chicago Fulton Market
Executive lounge

Level Chicago Fulton Market

4.0 star property
9.2 out of 10, Wonderful, (281)
"I liked the patio, location, hot tub and staff!"
The price is ￥44,737
￥55,828 total
includes taxes & fees
Sep 7 - Sep 8
Level Chicago Fulton Market
Hampton Inn & Suites Chicago Medical District UIC
Business center

Hampton Inn & Suites Chicago Medical District UIC

2.5 star property
9.6 out of 10, Exceptional, (238)
"This hotel was probably the cleanest hotel I’ve seen and their staff was very kind!"
The price is ￥26,829
￥31,497 total
includes taxes & fees
Sep 14 - Sep 15
Hampton Inn & Suites Chicago Medical District UIC
Hyatt House Chicago Medical/University District
Exterior

Hyatt House Chicago Medical/University District

3.5 star property
9.0 out of 10, Wonderful, (1103)
"Great stay, no complaints here"
The price is ￥31,831
￥37,366 total
includes taxes & fees
Sep 14 - Sep 15
Hyatt House Chicago Medical/University District
Hyatt Place Chicago Medical/University District
Lobby

Hyatt Place Chicago Medical/University District

3.0 star property
9.0 out of 10, Wonderful, (1286)
"Great place to stay!"
The price is ￥28,574
￥33,544 total
includes taxes & fees
Sep 11 - Sep 12
Hyatt Place Chicago Medical/University District
Travelodge by Wyndham Downtown Chicago
Lobby

Travelodge by Wyndham Downtown Chicago

2.0 star property
7.2 out of 10, Good, (2322)
"Helpful staff and convenient walking distances to many downtown Chicago attractions "
The price is ￥16,970
￥19,920 total
includes taxes & fees
Sep 22 - Sep 23
Travelodge by Wyndham Downtown Chicago
Best Western Grant Park Hotel
Restaurant

Best Western Grant Park Hotel

2.5 star property
8.2 out of 10, Very Good, (2606)
"Great place to stay for a concert or long weekend."
The price is ￥19,561
￥22,963 total
includes taxes & fees
Sep 22 - Sep 23
Best Western Grant Park Hotel
Residence Inn Chicago Downtown Magnificent Mile
Aerial view

Residence Inn Chicago Downtown Magnificent Mile

4.0 star property
9.6 out of 10, Exceptional, (338)
"Enjoyable stay at this Hotel in a very large room close to all the sights and shopping."
The price is ￥36,969
￥43,397 total
includes taxes & fees
Sep 21 - Sep 22
Residence Inn Chicago Downtown Magnificent Mile
Holiday Inn Express Chicago - Magnificent Mile by IHG
Exterior

Holiday Inn Express Chicago - Magnificent Mile by IHG

2.5 star property
8.4 out of 10, Very Good, (1003)
"Great hotel! "
The price is ￥23,904
￥28,062 total
includes taxes & fees
Sep 22 - Sep 23
Holiday Inn Express Chicago - Magnificent Mile by IHG
citizenM Chicago Downtown
Terrace/patio

citizenM Chicago Downtown

4.0 star property
9.2 out of 10, Wonderful, (3722)
"Great place to stay "
The price is ￥28,268
￥33,183 total
includes taxes & fees
Sep 22 - Sep 23
citizenM Chicago Downtown
The Chicago Hotel Collection River North
Building design

The Chicago Hotel Collection River North

3.0 star property
7.2 out of 10, Good, (584)
"It was a wonderful place to stay! "
The price is ￥20,172
￥23,680 total
includes taxes & fees
Oct 1 - Oct 2
The Chicago Hotel Collection River North
Freehand Chicago
Cocktail bar

Freehand Chicago

4.0 star property
8.0 out of 10, Very Good, (2288)
"Nice place to stay!"
The price is ￥16,044
￥21,447 total
includes taxes & fees
Sep 23 - Sep 24
Freehand Chicago
Congress Plaza Hotel
Banquet hall

Congress Plaza Hotel

3.5 star property
8.0 out of 10, Very Good, (9065)
"Great place to stay! Wonderful staff and ambience and walkable to many things. "
The price is ￥29,337
￥34,440 total
includes taxes & fees
Oct 4 - Oct 5
Congress Plaza Hotel
Claridge House
Cocktail bar

Claridge House

4.0 star property
8.8 out of 10, Excellent, (1348)
"Great stay highly recommend!! "
The price is ￥27,927
￥37,142 total
includes taxes & fees
Sep 7 - Sep 8
Claridge House
Thompson Chicago, by Hyatt
Restaurant

Thompson Chicago, by Hyatt

4.5 star property
9.2 out of 10, Wonderful, (1219)
"The location was great, the room was very nice, spacious and comfortable"
The price is ￥33,406
￥43,597 total
includes taxes & fees
Sep 28 - Sep 29
Thompson Chicago, by Hyatt
Central Loop Hotel
Breakfast, lunch, dinner served; American cuisine

Central Loop Hotel

4.0 star property
8.6 out of 10, Excellent, (1818)
"Amazing place to stay"
The price is ￥20,679
￥24,275 total
includes taxes & fees
Sep 21 - Sep 22
Central Loop Hotel
Bluegreen Vacations Hotel Blake, an Ascend Collection Hotel
Exterior

Bluegreen Vacations Hotel Blake, an Ascend Collection Hotel

4.0 star property
9.6 out of 10, Exceptional, (1013)
"Great stay"
The price is ￥27,560
￥32,351 total
includes taxes & fees
Sep 22 - Sep 23
Bluegreen Vacations Hotel Blake, an Ascend Collection Hotel
Hotel Saint Clair- Magnificent Mile
Restaurant

Hotel Saint Clair- Magnificent Mile

4.0 star property
8.2 out of 10, Very Good, (1681)
"Amazingly easy to find places to eat and shop. Great staff and very comfy beds"
Hotel Saint Clair- Magnificent Mile
Pendry Chicago
View from property

Pendry Chicago

4.5 star property
9.4 out of 10, Exceptional, (1080)
"Awesome hotel!"
The price is ￥38,602
￥51,417 total
includes taxes & fees
Sep 21 - Sep 22
Pendry Chicago
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in Illinois Medical District

Find the best Illinois Medical District areas and neighborhoods for the activities you enjoy most.
Downtown Chicago showing a city

Downtown Chicago

3 out of top 10 points of interest in this area

The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.

Magnificent Mile - River North

Magnificent Mile

Upscale shopping district with luxury department stores, boutiques, and acclaimed restaurants, featuring landmarks like the Wrigley Building and Chicago Water Tower. The Magnificent Mile is easily accessible by public transit and seasonal trolley service.

The Loop - Downtown which includes a river or creek

The Loop

Chicago's central business district boasts numerous global businesses, retail establishments, and theaters. Explore the Loop Retail Historic District, Chicago Landmark Historic Michigan Boulevard District, and visit iconic attractions like the Art Institute of Chicago.

River North showing railway items, street scenes and a city

River North

Artistic spirit thrives here, with art galleries and a design district featuring luxury interior furnishings. Explore Kingsbury Park, enjoy vibrant nightlife on Hubbard Street, and visit the iconic Contemporaine Building.

Chicago which includes modern architecture and a city

Lincoln Park

Upscale national retailers, boutiques, and bookstores abound in this affluent area, alongside numerous restaurants and coffee shops. Must-see attractions include Lincoln Park Zoo, Chicago History Museum, and North Avenue Beach. Easily accessible via CTA transit and major roads.

Top Illinois Medical District Hotel Reviews

The Allegro Royal Sonesta Hotel Chicago Loop

The Allegro Royal Sonesta Hotel Chicago Loop

10/10 Excellent
"loved our stay, great hotel and friendly staff"
Jared 2-night trip
Posted 2 days ago
The Allegro Royal Sonesta Hotel Chicago Loop

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Illinois Medical District?

Guests are sure to enjoy their time checking out all that Chicago's Illinois Medical District neighborhood has to offer.

Where is the best place to stay in Illinois Medical District?

Based on Expedia customer reviews, Hampton Inn & Suites Chicago Medical District UIC is the highest ranked property in Illinois Medical District. This hotel is a short 15-minute walk from United Center, and it offers free breakfast and an indoor pool. Another top choice in the area is Hyatt Place Chicago Medical/University District.

How many hotels are there in the Illinois Medical District area?

If you're searching for places to stay in Chicago, choose from one of Expedia's 17 hotels and other accommodations in Illinois Medical District.

If I need to cancel my hotel reservation in Illinois Medical District, will I receive a refund?

Yes! Most hotel reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best options available in Illinois Medical District.

Where can I learn more about changing or cancelling my trip to Illinois Medical District?

To access more information about changing or cancelling your trip to Illinois Medical District, head over to our customer service page.

What can I see and do in this Chicago neighborhood?

Don't miss favorite places to visit in the surrounding area, such as Michigan Avenue, United Center, and Soldier Field. Michael Jordan Statue and National Museum of Mexican Art are also worth a visit when you're out sightseeing in Chicago.

How can I get around Illinois Medical District and the greater Chicago area?

Ready to get out and explore the city? Polk Station (Pink Line) is the closest metro station.